Results 111 to 120 of about 57,421 (279)

Dose-Dependent Effects on Sphingoid Bases and Cytokines in Chickens Fed Diets Prepared with Fusarium Verticillioides Culture Material Containing Fumonisins

Toxins, 2015
In chickens, the effect of mycotoxins, especially fumonisins (FB), in the gastrointestinal tract (GIT) is not well documented. Thus, this study in broiler chicks determined the effects of consuming diets prepared with Fusarium verticillioides culture ...
Bertrand Grenier, Heidi E. Schwartz-Zimmermann, Sylvia Caha, Wulf Dieter Moll, Gerd Schatzmayr, Todd J. Applegate   +5 more
doaj   +1 more source

Sphingosine kinase 1 as an anticancer therapeutic target

, 2015
Ying Gao,1,* Fei Gao,2,* Kan Chen,3,* Mei-li Tian,1 Dong-li Zhao1 1Department of Radiotherapy Oncology, First Affiliated Hospital of Xi’an Jiaotong University, 2Department of Neurology, First Affiliated Hospital of Xi’an Medical University ...
Chen K, Gao Y, Tian ML, Gao F, Zhao DL
core  

Sphingosine-1-phosphate receptor 1 signalling in bacterial-macrophage interactions: exploring novel anti-bacterial strategies using immunomodulatory therapeutics

, 2020
Sphingosine-1-Phosphate (S1P) signalling via the Sphingosine-1- posphate Receptors (S1PRs) 1-5 profoundly influences the host-immune response to infection. In this study, the effect of S1PR1 signalling on the interactions between a murine macrophage-like
J Dyer (13702297)
core  

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase

Journal of Lipid Research, 2017
Glucosylceramide (GlcCer) is the primary storage lipid in the lysosomes of Gaucher patients and a secondary one in Niemann-Pick disease types A, B, and C.
Misbaudeen Abdul-Hammed, Bernadette Breiden, Günter Schwarzmann, Konrad Sandhoff   +3 more
doaj   +1 more source

Sphingosine Kinases as Druggable Targets

, 2018
There is substantial evidence that the enzymes, sphingosine kinase 1 and 2, which catalyse the formation of the bioactive lipid sphingosine 1-phosphate, are involved in pathophysiological processes.
Nigel J. Pyne, Pyne, Nigel J., David R. Adams, Pyne, Susan, Susan Pyne, Adams, David Roger   +5 more
core   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Separation of long-chain bases by thin-layer chromatography; instability of sphingosine

Journal of Lipid Research, 1965
Purified sphingosine was resolved into dihydrosphingosine, sphingosine, and a fast-moving component thin-layer chromatography on Silica Gel G. The fast-moving component was generated by the adsorbent, and consisted of a mixture of the cationic forms of ...
Benjamin Weiss, Richard L. Stiller
doaj   +1 more source

An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes

, 2004
Sphingosine kinase catalyses the phosphorylation of sphingosine to generate sphingosine 1-phosphate, a lipid signaling molecule implicated in roles in a diverse range of mammalian cell processes through its action as both a ligand for G-protein-coupled ...
Pitson, S., Darrow, A., Moretti, P., Derian, C., Roberts, J., Vadas, M.   +5 more
core   +1 more source

Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies

Journal of Lipid Research, 2006
Recombinant human ceramide kinase (HsCERK) was analyzed with regard to dependence on divalent cations and to substrate delivery, spectrum, specificity, and stereoselectivity.
Helena Van Overloop, Sofie Gijsbers,, Paul P. Van Veldhoven   +2 more
doaj   +1 more source