Results 1 to 10 of about 5,394 (197)

Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d [PDF]

Scientific Reports, 2017
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines.
Joren Guillaume, Jing Wang, Jonas Janssens, Soumya G. Remesh, Martijn D. P. Risseeuw, Tine Decruy, Mathy Froeyen, Dirk Elewaut, Dirk M. Zajonc, Serge Van Calenbergh   +9 more
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Phytosphingosine, a sphingolipid isolated from fungal endophyte Penicillium oxalicum, exerts cytotoxic effects against breast cancer cells and shows blood compatibility [PDF]

Scientific Reports
Plant-associated fungal endophytes hold great potential to synthesize metabolites similar to their host, with potential anticancer effects. The present study aims to identify lead compound in the ethyl acetate (EA) extract of fungal endophyte ...
Ashish Verma, Swati Singh, Priyamvada Gupta, Harshita Tiwari, Lalit Kumar, M. K. Bharty, Vibhav Gautam   +6 more
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A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders [PDF]

Cell Discovery
According to traditional Chinese medicine (TCM) constitutional theory, individuals with phlegm-dampness constitution (PDC) are at increased risk for metabolic disorders. Previous studies have indicated that PDC individuals exhibit gene expression changes
Lingru Li, Tianxing Li, Xue Liang, Linghui Zhu, Yini Fang, Ling Dong, Yi Zheng, Xiaoxue Xu, Mingrui Li, Tianqi Cai, Fufangyu Zhao, Meiling Xin, Mingyan Shao, Yuanyuan Guan, Meiyi Liu, Fangli Li, Chenhong Zhang, Qi Wang, Wenlong Sun, Yanfei Zheng   +19 more
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Phytosphingosine Alleviates Cigarette Smoke‐Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4 [PDF]

MedComm
Chronic obstructive pulmonary disease (COPD) is a complex and irreversible respiratory disorder with a poor prognosis and a lack of effective pharmaceutical treatment.
Yuan Zhan, Zhesong Deng, Ruonan Yang, Shanshan Chen, Jiaheng Zhang, Yating Zhang, Hao Fu, Qian Huang, Yiya Gu, Zhilin Zeng, Jinkun Chen, Jixian Zhang, Jixing Wu, Jungang Xie   +13 more
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Secondary metabolites of Minutisphaera thailandensis and Hongkongmyces kokensis revealed by LC–QTOF–MS and their antimicrobial and cytotoxic activities [PDF]

Scientific Reports
The mycelial extracts of two novel fungal species, Minutisphaera thailandensis and Hongkongmyces kokensis, were investigated for their antimicrobial, cytotoxic, and secondary metabolite profiles to assess their potential as sources of bioactive natural ...
Sarunpron Khruengsai, Teerapong Sripahco, Prasat Kittakoop, Patcharee Pripdeevech   +3 more
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Advances in the biosynthesis of tetraacetyl phytosphingosine, a key substrate of ceramides [PDF]

Synthetic and Systems Biotechnology
Ceramides, formed by the dehydration of long-chain fatty acids with phytosphingosine and its derivatives, are widely used in skincare, cosmetics, and pharmaceuticals. Due to the exceedingly low concentration of phytosphingosine in plant seeds, relying on
Xin Zhang, Xiaochen Zhang, Lu Lin, Kaifeng Wang, Xiao-Jun Ji   +4 more
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Phytosphingosine contributes gut microbiota metabolism to alleviate low-grade endotoxemia-induced mastitis [PDF]

Microbiome
Background Recently, evidence has indicated that mastitis is closely associated with the ruminal dysbiosis caused by subacute ruminal acidosis (SARA) and subsequent low-grade endotoxemia (LGE).
Yihong Zhao, Hongyan Li, Jiawen Xu, Haiqi Li, Lijuan Bao, Keyi Wu, Min Qiu, Hang Yu, Shan Shang, Yuhong He, Chongshan Yuan, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu, Wenjia Li, Caijun Zhao, Jun Wang   +16 more
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Efficacy Evaluation of N-Acyl-Phytosphingosine Prepared from Marula Oil Derived Fatty Acids in Skin Barrier Repair [PDF]

Clinical, Cosmetic and Investigational Dermatology
Zhongwang Liu, Huilin Zhu, Yuge Yang, Huailong Chang Global Research and Development Center, Shanghai Chicmax Cosmetic Co., Ltd., Shanghai, People’s Republic of ChinaCorrespondence: Zhongwang Liu, Global Research and Development Center, Shanghai Chicmax ...
Liu Z, Zhu H, Yang Y, Chang H
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A novel fluorescein sodium-based screening platform for the identification of sphingoid base-producing Wickerhamomyces ciferrii mutants [PDF]

Frontiers in Bioengineering and Biotechnology
The efficient identification of microbial strains capable of producing rare sphingoid bases, such as sphingosine and sphinganine, is critical for advancing microbial fermentation processes and addressing increasing industrial demands.
Jun Su Kang, Seong-Rae Lee, Minju Lee, Eunha Kim, Pyung Cheon Lee   +4 more
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Gas-liquid chromatography-mass spectrometry of synthetic ceramides containing phytosphingosine

Journal of Lipid Research, 1970
Ceramides containing phytosphingosine as base and one of the fatty acids 16:0, 18:0, 20:0, 22:0, 23:0, and 24:0, were prepared by direct coupling in the presence of a mixed carbodiimide. The ceramides were analyzed as the 1,3,4-tri-O-trimethylsilyl ether
Sven Hammarström
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