Results 91 to 100 of about 57,421 (279)

Rôle de la sphingosine 1-phosphate dans les interactions mélanome-stroma

, 2012
Le mélanome métastatique demeure un cancer au sombre pronostic, et aucune des thérapies conventionnelles n'a pu apporter de bénéfice sur la survie globale.
Albinet, Virginie
core  

Analysis of sphingosine levels from BAL.

, 2022
After a 15-minute nebulization of a 5 mL sphingosine suspension containing 500 μM sphingosine in 0.9% saline or 5 ml 0.9% saline as control a fiberoptic videoscope was used to extract BAL.
Burkhard Kleuser (248982), Carolin Sehl (11201733), Rabea Verhaegh (652638), Anne Katrin Becker (13132816), Markus Kamler (11331104), Barbara Wilker (13132810), Michael Hübler (6994445), Simone Keitsch (13132813), Matthias Soddemann (13132807), Katharina Kalka (13132804), Henning Carstens (13132801), Erich Gulbins (168247), Achim Koch (13132819), Fabian Schumacher (1349175), Ursula Rauen (316513)   +14 more
core   +1 more source

Drought Risk in Mango and Avocado Orchards: Insights Into Plant Water Relations and Irrigation‐Related Agronomic Solutions

Irrigation and Drainage, EarlyView.
ABSTRACT Climate change is making water availability more uncertain, with growing consequences for the productivity and long‐term sustainability of tropical and subtropical fruit orchards. Mangifera indica L. and Persea americana Mill. both require large amounts of water to sustain growth and productivity.
Eleonora Cataldo
wiley   +1 more source

Studies on Sphingosines. 9. C19-Sphingosines, hitherto Unknown Sphingosines. [PDF]

Acta Chemica Scandinavica, 1965
Karl-Anders Karlsson, Göran A. L. Holm, I. Turtóczky, I. Fedorcsák, Ragnar A. Hoffman, Anders Westerdahl   +5 more
openaire   +2 more sources

Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection

, 2011
High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the ...
Hacking, Damian
core  

Sphingosine kinase 1 is critically involved in nitric oxide-mediated human endothelial cell migration and tube formation

, 2010
Sphingosine kinases (SKs) convert sphingosine to sphingosine 1-phosphate (S1P), which is a bioactive lipid that regulates a variety of cellular processes including proliferation, differentiation and ...
Stephanie Schwalm, Josef Pfeilschifter, Pfeilschifter, Josef, Huwiler, Andrea, Andrea Huwiler, Schwalm, Stephanie   +5 more
core   +1 more source

Sphingosine kinases as druggable targets [PDF]

, 2020
There is substantial evidence that the enzymes, sphingosine kinase 1 and 2, which catalyse the formation of the bioactive lipid, sphingosine 1-phosphate are involved in physiological and pathophysiological processes.
Pyne, Nigel J., Pyne, Susan, Adams, David R.   +2 more
core  

Reconceptualizing Aplastic Anemia—Seed, Worm, Soil

Journal of Clinical Laboratory Analysis, EarlyView.
Aplastic anemia (AA) encompasses a group of hematological syndromes often misdiagnosed, resulting in a decrease in the overall blood cell count and representing a form of bone marrow failure. We reinterpret AA based on the “seed, worm, and soil” doctrine.
Xintong Xu, Zining Wang, Jiaming Hu, Chunyan Liu, Rong Fu   +4 more
wiley   +1 more source

Sphingolipid Metabolism Perturbations in Rett Syndrome

Metabolites, 2019
Rett syndrome is a severe neurodevelopmental disorder affecting mostly females and is caused by loss-of-function mutations in the MECP2 gene that encoded the methyl-CpG-binding protein 2.
Gerarda Cappuccio, Taraka Donti, Michele Pinelli, Pia Bernardo, Carmela Bravaccio, Sarah H. Elsea, Nicola Brunetti-Pierri   +6 more
doaj   +1 more source

Sphingosine–sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization

, 2012
Sphingosine and sphingosine-1-phosphate (S1P) are involved in regulating cell differentiation. This study postulated that changes in sphingolipid biosynthesis and metabolism are important in trophoblast syncytialization and therefore examined the ...
Singh, A., Keelan, J., Irving L.M.H. Aye, Jeffrey A. Keelan, Aye, I., Dharmarajan, Arunasalam, Ambika T. Singh, Arunasalam Dharmarajan   +7 more
core   +1 more source