Results 101 to 110 of about 61,732 (250)
Sphingolipids as Emerging Mediators in Retina Degeneration
Frontiers in Cellular Neuroscience, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
M. Victoria Simón +3 more
doaj +1 more source
Allergy, EarlyView.Skin tape strip lipidomic analysis revealed preexisting skin barrier lipid abnormalities at day 0 that were further exacerbated after 6 weeks of CPI treatment. Significant changes in skin (but not plasma) proinflammatory cytokines were identified in future ircAE patients after 6 weeks of CPI immunotherapy.
Taras Lyubchenko +9 more
wiley +1 more source
Toxins, 2015 In chickens, the effect of mycotoxins, especially fumonisins (FB), in the gastrointestinal tract (GIT) is not well documented. Thus, this study in broiler chicks determined the effects of consuming diets prepared with Fusarium verticillioides culture ...
Bertrand Grenier +5 more
doaj +1 more source
Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase
Journal of Lipid Research, 2017 Glucosylceramide (GlcCer) is the primary storage lipid in the lysosomes of Gaucher patients and a secondary one in Niemann-Pick disease types A, B, and C.
Misbaudeen Abdul-Hammed +3 more
doaj +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.Dupilumab improved all histological, symptomatic, and endoscopic outcomes assessed at Week 24 versus placebo in patients with eosinophilic oesophagitis, regardless of demographics, disease characteristics, treatment history, or type 2 inflammatory disease comorbidities.
Evan S. Dellon +7 more
wiley +1 more source
Sphingosine kinase and sphingosine 1-phosphate in the heart: A decade of progress [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013 Activation of sphingosine kinase/sphingosine 1-phosphate (SK/S1P)-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. S1P is released in both ischemic pre- and post-conditioning. Application of exogenous S1P to cultured cardiac myocytes subjected to hypoxia or treatment of isolated ...
openaire +4 more sources
Separation of long-chain bases by thin-layer chromatography; instability of sphingosine
Journal of Lipid Research, 1965 Purified sphingosine was resolved into dihydrosphingosine, sphingosine, and a fast-moving component thin-layer chromatography on Silica Gel G. The fast-moving component was generated by the adsorbent, and consisted of a mixture of the cationic forms of ...
Benjamin Weiss, Richard L. Stiller
doaj +1 more source
Generierung von Sphingosin-1-Phosphat durch apoptotische Zellen und dessen Einfluss auf die Polarisierung von Makrophagen während der Tumorentwicklung [PDF]
, 2008 The removal of apoptotic cells (AC) can be regarded as an integral component of the program to terminate inflammation. Clearance of AC by professional phagocytes such as macrophages induces an anti-inflammatory phenotype in the latter ones.
Weigert, Andreas
core
British Journal of Pharmacology, EarlyView.Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher +6 more
wiley +1 more source
Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis
World Journal of Biological Chemistry, 2010 The importance of sphingosine kinase (SphK) and sphingosine-1-phosphate (S1P) in inflammation has been extensively demonstrated. As an intracellular second messenger, S1P plays an important role in calcium signaling and mobilization, and cell proliferation and survival.
Wen-Qi, Lai +2 more
openaire +2 more sources