Results 121 to 130 of about 61,732 (250)

Studies on Sphingosines. 6. C16- and C17-Sphingosines, hitherto Unknown Sphingosines. [PDF]

Acta Chemica Scandinavica, 1964
Karl-Anders Karlsson, O. Hassel, Chr. Römming, D. R. Sparrow   +3 more
openaire   +1 more source

Initial OX40–OX40L Signaling Promotes a Skin‐Resident Memory T‐Cell Reservoir in Atopic Dermatitis

Allergy, EarlyView.
Takayoshi Komatsu‐Fujii, Ryota Asahina, Tatsuya Hasegawa, Satoshi Nakamizo, Saeko Nakajima, Toshiaki Kogame, Kenji Kabashima   +6 more
wiley   +1 more source

A film of tuberose polysaccharide supports normal epidermal keratinization by suppressing cytokine release induced by external stimuli

International Journal of Cosmetic Science, EarlyView.
(a) Dry, rough skin has an immature stratum corneum prone to stimuli, triggering IL‐1α/IL‐1ra/IL‐8 release, keratinization defects, reduced ceramide NP/NS and lipids, scaling and poor hydration. (b) TPS forms a flexible reticular film, shielding the SC, lowering cytokines, normalizing differentiation, restoring lipids and improving texture and water ...
Junko Ishikawa, Yuka Yasuda
wiley   +1 more source

Systemic Lipidomics Identifies Altered Ceramide–Phospholipid Balance Associated With Periodontitis Severity: A Cross‐Sectional Study With 12‐Year Follow‐Up

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate whether periodontitis stage and grade are associated with circulating active lipid mediators and whether baseline lipid species predict periodontitis progression. Materials and Methods The study included 473 Finnish participants from the Parogene cohort undergoing coronary angiography, with 12‐year follow‐up data available ...
Minja Tuomivaara, Anne‐Mari Halme, Muhammed Manzoor, Elina Salasuo, Susanna Paju, Päivi Mäntylä, Kåre Buhlin, Laura Lahdentausta‐Suomalainen, Reijo Laaksonen, Juha Sinisalo, Pirkko Pussinen, Aino Salminen   +11 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

M1 macrophage‐derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage‐derived exosomes in DN progression remains largely unexplored. Methods THP‐1 monocytes were differentiated into M0 macrophages and polarized into M1 macrophages for exosome extraction.
Lei Li, Hongmei Liu, Yu Mao, Huanhuan Wang, Lige Song, Zhiqiang Kang   +5 more
wiley   +1 more source

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Obesity Modifies Sphingolipid Signatures in Childhood Asthma

Clinical &Experimental Allergy, EarlyView.
Harshita Shailesh, Alaa Abdelhamid, Ahmed Arabi, Yaman Al‐Haneedi, Shana Jacob, Giridhara Rathnaiah Babu, Stefan Worgall, Ibrahim Janahi   +7 more
wiley   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source