Results 171 to 180 of about 102,609 (313)

Studies on Sphingosines. 6. C16- and C17-Sphingosines, hitherto Unknown Sphingosines. [PDF]

Acta Chemica Scandinavica, 1964
Karl-Anders Karlsson, O. Hassel, Chr. Römming, D. R. Sparrow   +3 more
openaire   +1 more source

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

Extraction Methods and an Investigation of Drosophila Lipids [PDF]

, 1959
In earlier work (8) we extracted lipids from dried, macerated Drosophila melanogaster with ether, but later, working with larger quantities of undried flies, we found that most of the phospholipids were autolyzed.
Mitchell, Herschel K., Wren, J. J.
core  

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Treg Cells Modulate Neuroinflammation and Behavioral Deficits in Autism: Evidence From MR‐Based Genetic Analyses and Experimental Models

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 2, Page 127-143, March 2026.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD.
Zuqing Nie, Xinyi Xu, Junhao Chen, Huiling Chen, Meng Li, Yang Zhang, Zhiwei Li, Chen Shen, Jie Wen, Xia Cao   +9 more
wiley   +1 more source

The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. [PDF]

, 2015
The orphan Gα13-coupled receptor P2RY8 is mutated in human germinal center (GC)-derived lymphomas and was recently found to promote B cell association with GCs in a mouse model. Here we establish that P2RY8 promotes clustering of activated B cells within
Cyster, Jason G, Lu, Erick, Muppidi, Jagan R   +2 more
core  

Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 678-687, March 2026.
Vascular leakage and its associated phenomena vasodilation and endothelial activation are pathophysiological features of various diseases. Multiple drug candidates targeting these phenomena are in development, necessitating translational models to demonstrate proof‐of‐pharmacology and proof‐of‐mechanism in early‐phase clinical trials.
Marella Cornelia Elizabeth van Ruissen, Menno van Diemen, Liza Botros, Ingrid Tomljanovic, Hind Achbo, Dimitra Eleftheriou, Paul Willem Schenk, Naomi Bertine Klarenbeek, Derek William Gilroy, Manon Aleida Adriana Jansen, Matthijs Moerland   +10 more
wiley   +1 more source

Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression

Glia, Volume 74, Issue 3, March 2026.
Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Carla Peiró‐Moreno, Juan Carlos Chara, Katy Marshall‐Phelps, Irune Ugarte‐Arakistain, Stefano Calovi, Rafael Gois De Almeida, María Domercq, Carlos Matute   +7 more
wiley   +1 more source

Functional Training Mitigates Reduced Circulating Indole‐3‐Lactate Levels in Persons With Relapsing–Remitting Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim Indoles are tryptophan (Trp)‐derived metabolites that are produced by the gut microbiota and may influence the gut‐microbiota‐brain axis in multiple sclerosis (MS). Indole‐3‐lactate (ILA) is reduced in persons with MS and improves MS clinical scores in animal models via its anti‐inflammatory remyelinating properties.
Tiffany Wences Chirino, Frederike Adammek, Sergen Belen, Matteo Winker, Sebastian Proschinger, Annette Rademacher, Marit L. Schlagheck, Alexander Schenk, Marie Kupjetz, David Walzik, Clemens Warnke, Marcel Reuter, Friederike Rosenberger, Tim Meyer, Adrian McCann, Per Magne Ueland, Niklas Joisten, Philipp Zimmer   +17 more
wiley   +1 more source

Defective high‐density lipoprotein lipoprotection in type 2 diabetes during acute myocardial infarction is rescued by apolipoprotein M/sphingosine‐1‐phosphate loading

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 2175-2182, March 2026.
Abstract Aims Mortality of patients with type 2 diabetes (T2D) after acute myocardial infarction (AMI) is tremendous and massively increased compared to non‐T2D individuals. The reasons are unclear. High‐density lipoprotein (HDL) conducts lipoprotection during AMI, leading to improved outcomes.
Jens Vogt, Marcel Benkhoff, Nathalie H. Schröder, Hao Hu, Lisa Dannenberg, Petra Keul, Theresia Sarabhai, Kálmán Benedikt Bódis, Tobias Zeus, Philipp Wollnitzke, Malte Kelm, Amin Polzin, Bodo Levkau   +12 more
wiley   +1 more source