Results 191 to 200 of about 102,609 (313)

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα‐Fold Arrangement

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 515-528, February 2026.
ABSTRACT Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi‐systemic abnormalities and significant phenotypic variability including neurodevelopmental delay, seizures, intermittent ataxia, hypothyroidism, rhabdomyolysis, life‐threatening metabolic ...
Anne Cooper, Alyssa Powers, Kevin P. Battaile, Al‐Walid Mohsen, David K. Johnson, Scott Lovell, Lina Ghaloul‐Gonzalez   +6 more
wiley   +1 more source

Gut Microbiome Dysbiosis is Associated With Human T‐Lymphotropic Virus Type 1 (HTLV‐1) Infection and Disease Progression to HTLV‐1‐Associated Myelopathy/Tropical Spastic Paraparesis: A Cross‐Sectional Study

Smart Medicine, Volume 5, Issue 1, February 2026.
We provide the first comprehensive analysis of changes in the gut bacteriome at different clinical stages of HTLV‐1 infection. HTLV‐1 infection is associated with a dysbiosis that includes reduced bacterial diversity and an inverted Firmicutes/Bacteroidetes ratio.
Lorena Abreu Fernandes, Ana Olivia de Souza, Youko Nukui, Rosa Maria Marcusso, Augusto César Penalva de Oliveira, Jorge Casseb, Patricia Bianca Clissa, Silas G. Villas‐Boas, Sabri Saeed Sanabani   +8 more
wiley   +1 more source

Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma. [PDF]

Int J Biol Sci
Jang HR, Kim HJ, Kim BY, Jeong JH, Kim JK, Won JA, Yoo HH, Lee YG, Yim H.   +8 more
europepmc   +1 more source

Skin Lipid–Microbe Interplay Links Staphylococcus hominis to Barrier Control in Adult Atopic Dermatitis

Allergy, Volume 81, Issue 2, Page 454-467, February 2026.
This study investigates mutual interaction of skin microbes and surface lipids in AD using the advanced method of shotgun lipidomics with ultra‐broad coverage of lipids and 16S amplicon sequencing of tape strips taken from lesional and non‐lesional AD and healthy controls.
Madhumita Bhattacharyya, Felix Lauffer, Manja Jargosch, Kristina Frey, Mahsa Shahidi Dadras, Theresa Raunegger, Sophia Wasserer, Carsten B. Schmidt‐Weber, Tilo Biedermann, Kilian Eyerich, Stefanie Eyerich, Claudia Traidl‐Hoffmann, Christian Klose, Matthias Reiger, Natalie Garzorz‐Stark   +14 more
wiley   +1 more source

Targeting ceramide metabolism to restore hypoxia-induced apoptosis in p53-deficient colon cancer cells. [PDF]

PLoS One
Mechleb K, Hourani N, Fakhry M, Alyamani OA, Hage-Sleiman R, Younes H, Fayad AA, Soudani N, Sakr A, Darwiche N, Nemer G, Saab R, Mrad M, Dbaibo G.   +13 more
europepmc   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis. [PDF]

World J Diabetes
Chen JY, Ji Z, Guo K, Wang HN, Zhu CC, Li T, Zhao XB, Wang YT, Li Q, Jin PS, Li XY.   +10 more
europepmc   +1 more source

Sphingosine 1-phosphate and cancer.

Advances in Biological Regulation, 2017
N. Pyne, Ashref El Buri, D. Adams, S. Pyne   +3 more
semanticscholar   +1 more source