Results 211 to 220 of about 61,732 (250)

Sphingosine in apoptosis signaling

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2002
The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite sphingosine act as negative regulators of cell proliferation and promote apoptosis. Conversely, sphingosine 1-phosphate, formed by phosphorylation of sphingosine by a sphingosine kinase,
Olivier Cuvillier
exaly   +3 more sources

Sphingosin und Sphingosin‐ähnliche Verbindungen

Helvetica Chimica Acta, 1959
AbstractThe syntheses of several unsaturated long‐chain aminodiols of the sphingosine type are described. Their physical properties and biological activities are noted.
E. F. Jenny, J. Druey
openaire   +1 more source

Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase)

Chemistry and Physics of Lipids, 2016
Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. Among them, sphingosine 1 phosphate (S1P) is a recognized promoter of cell survival, also involved, inter alia, in inflammation and tumorigenesis processes. The knowledge and modulation of the enzymes implicated in the biosynthesis and degradation of S1P are ...
Pol, Sanllehí, José-Luis, Abad, Josefina, Casas, Antonio, Delgado   +3 more
openaire   +2 more sources

Synthesis and Evaluation of Sphingosine Analogues as Inhibitors of Sphingosine Kinases

Journal of Medicinal Chemistry, 2009
Sphingolipid-metabolizing enzymes control the critical balance of the cellular levels of sphingolipids, including the apoptotic inducing ceramide (Cer) and the proliferative inducing sphingosine 1-phosphate (S1P). The production of S1P, catalyzed by the action of sphingosine kinases (SPHKs), is known to be critical for many cellular processes. However,
Wong, L., Tan, S.S.L., Lam, Y., Melendez, A.J.   +3 more
openaire   +2 more sources

Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway

2013
Sphingolipids have emerged as pleiotropic signaling molecules with roles in numerous cellular and biological functions. Defining the regulatory mechanisms governing sphingolipid metabolism is crucial in order to develop a complete understanding of the biological functions of sphingolipid metabolites.
K Alexa Orr, Gandy, Lina M, Obeid
openaire   +2 more sources

Sphingosine and Sphingosine 1 Phosphate in the Brain

2011
Sphingosine is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain. It is found in sphingolipids (cerbroside, sulfatide, and ganglioside) as well as phospholipid (sphingomyelin) (Fig. 9.1). Sphingomyelin (SM) is the major membrane sphingolipid and is the precursor for ceramide and sphingosine.
openaire   +1 more source

Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2

Bioorganic & Medicinal Chemistry Letters, 2004
Fluorescently labeled d-erythro-sphingosines have been successfully synthesized in 9 and 12 steps starting from commercially available Garner aldehyde. Determining the influence of the nature, position and linkage of the label on the in vitro phosphorylation rate by sphingosine kinases 1 and 2 resulted in the identification of a pyrene- and a NBD ...
Peter, Ettmayer, Andreas, Billich, Thomas, Baumruker, Diana, Mechtcheriakova, Heide, Schmid, Peter, Nussbaumer   +5 more
openaire   +2 more sources

Sphingosine

2007
S.J. Enna, David B. Bylund
openaire   +1 more source

Activation of sphingosine kinase 1 by ERK1/2‐mediated phosphorylation

EMBO Journal, 2003
Stuart M Pitson, Pu Xia, Paul Moretti
exaly  

Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

Progress in Lipid Research, 2016
Nigel J Pyne, Susan Pyne, David R Adams
exaly