ATRA improves megakaryopoiesis in immune thrombocytopenia through up-regulating the HIF-1α/SPHK2/S1P pathway. [PDF]
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Low serum sphingosine-1-phospate and its chaperone ApoM associate with retinopathy of prematurity. [PDF]
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Targeting ceramide metabolism to restore hypoxia-induced apoptosis in p53-deficient colon cancer cells. [PDF]
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Safety and efficacy of etrasimod in ulcerative colitis: Evidence from a meta-analysis. [PDF]
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Correction to: Associations of sphingosine‑1‑phosphate with soluble P‑selectin and adverse clinical outcome in patients with cerebral ischemia with and without acetylsalicylic acid treatment. [PDF]
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Correction to "Blocking Sphingosine 1-phosphate Metabolism With Fingolimod Prevents the Progression of Vascular Smooth Muscle Cells Calcification in Chronic Kidney Disease". [PDF]
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Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2002The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and cell death. Cer and Sph usually inhibit proliferation and promote apoptosis, while the further metabolite S1P stimulates growth and suppresses apoptosis.
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