Results 241 to 250 of about 57,421 (279)

Sphingosine in apoptosis signaling

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2002
The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite sphingosine act as negative regulators of cell proliferation and promote apoptosis. Conversely, sphingosine 1-phosphate, formed by phosphorylation of sphingosine by a sphingosine kinase,
Olivier Cuvillier
exaly   +3 more sources

Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo

Circulation Research, 2015
RATIONALE Platelets are known to play a crucial role in hemostasis. Sphingosine kinases (Sphk) 1 and 2 catalyze the conversion of sphingosine to the bioactive metabolite sphingosine 1-phosphate (S1P).
Nicole Urtz, Florian Gaertner, Martin Orban   +2 more
exaly   +2 more sources

Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics

Prostaglandins & Other Lipid Mediators, 2005
It has become abundantly clear over the past decade that sphingolipids and their metabolites are key signaling molecules. Ceramide, the backbone of all sphingolipids, predominantly inhibits cell growth and induces apoptosis, while its metabolite, sphingosine-1-phosphate promotes growth and survival.
Michael, Maceyka, Sheldon, Milstien, Sarah, Spiegel   +2 more
openaire   +2 more sources

Synthesis of fluorescence-Labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior

Bioorganic & Medicinal Chemistry Letters, 2003
A fluorescence-labeled sphingosine and sphingosine 1-phosphate have been successfully synthesized from the oxazolidinone methyl ester derived from glycidol via monoalkylation and the stereoselective reduction of the resulting ketone. The labeled sphingosine was converted into its phosphate by treatment with sphingosine kinase 1 (SPHK1) from mouse, and ...
Toshikazu, Hakogi, Toshihiko, Shigenari, Shigeo, Katsumura, Takamitsu, Sano, Takayuki, Kohno, Yasuyuki, Igarashi   +5 more
openaire   +2 more sources

Sphingosin und Sphingosin‐ähnliche Verbindungen

Helvetica Chimica Acta, 1959
AbstractThe syntheses of several unsaturated long‐chain aminodiols of the sphingosine type are described. Their physical properties and biological activities are noted.
E. F. Jenny, J. Druey
openaire   +1 more source

Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase)

Chemistry and Physics of Lipids, 2016
Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. Among them, sphingosine 1 phosphate (S1P) is a recognized promoter of cell survival, also involved, inter alia, in inflammation and tumorigenesis processes. The knowledge and modulation of the enzymes implicated in the biosynthesis and degradation of S1P are ...
Pol, Sanllehí, José-Luis, Abad, Josefina, Casas, Antonio, Delgado   +3 more
openaire   +2 more sources

Synthesis and Evaluation of Sphingosine Analogues as Inhibitors of Sphingosine Kinases

Journal of Medicinal Chemistry, 2009
Sphingolipid-metabolizing enzymes control the critical balance of the cellular levels of sphingolipids, including the apoptotic inducing ceramide (Cer) and the proliferative inducing sphingosine 1-phosphate (S1P). The production of S1P, catalyzed by the action of sphingosine kinases (SPHKs), is known to be critical for many cellular processes. However,
Wong, L., Tan, S.S.L., Lam, Y., Melendez, A.J.   +3 more
openaire   +2 more sources

Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway

2013
Sphingolipids have emerged as pleiotropic signaling molecules with roles in numerous cellular and biological functions. Defining the regulatory mechanisms governing sphingolipid metabolism is crucial in order to develop a complete understanding of the biological functions of sphingolipid metabolites.
K Alexa Orr, Gandy, Lina M, Obeid
openaire   +2 more sources

[40] Synthesis of sphingosine, radiolabeled-sphingosine, 4-methyl-cis-sphingosine, and 1-amino derivatives of sphingosine via their azido derivatives

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Karl-Heinz Jung, Richard R. Schmidt
openaire   +2 more sources

Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2

Bioorganic & Medicinal Chemistry Letters, 2004
Fluorescently labeled d-erythro-sphingosines have been successfully synthesized in 9 and 12 steps starting from commercially available Garner aldehyde. Determining the influence of the nature, position and linkage of the label on the in vitro phosphorylation rate by sphingosine kinases 1 and 2 resulted in the identification of a pyrene- and a NBD ...
Peter, Ettmayer, Andreas, Billich, Thomas, Baumruker, Diana, Mechtcheriakova, Heide, Schmid, Peter, Nussbaumer   +5 more
openaire   +2 more sources