Sphingolipid Remodeling in Colorectal Cancer Reveals a Continuum-like Metabolic Organization. [PDF]
Antioxidants (Basel)Markowski AR +8 more
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Decoding the S1P-S1PR axis in cancer: Mechanisms, pathways and therapeutic horizons (Review). [PDF]
Biomed RepChuang YT, Wu IH, Lee CF, Lee H.
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Association of <i>SPHK1</i> polymorphisms with Alzheimer's disease susceptibility: Functional impact of the rs2247856 SNP on transcriptional efficiency. [PDF]
Alzheimers Dement (N Y)Kim DJ, Kim YC, Jeong BH.
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Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2002The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and cell death. Cer and Sph usually inhibit proliferation and promote apoptosis, while the further metabolite S1P stimulates growth and suppresses apoptosis.
Sarah Spiegel, Shawn G Payne
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Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo [PDF]
Circulation Research, 2015 RATIONALE Platelets are known to play a crucial role in hemostasis. Sphingosine kinases (Sphk) 1 and 2 catalyze the conversion of sphingosine to the bioactive metabolite sphingosine 1-phosphate (S1P).
Florian Gaertner +2 more
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Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2017 Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for the phosphorylation of sphingosine to S1P. Many stimuli increase sphingosine kinase activity and S1P production and secretion.
Sarah Spiegel, Michael Maceyka
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Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
Biochimica Et Biophysica Acta - Biomembranes, 2006 Sphingolipids are ubiquitous components of cell membranes and their metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important physiological functions, including regulation of cell growth and survival. Cer and Sph are associated with growth arrest and apoptosis.
Steven W Paugh +2 more
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Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics
Prostaglandins & Other Lipid Mediators, 2005It has become abundantly clear over the past decade that sphingolipids and their metabolites are key signaling molecules. Ceramide, the backbone of all sphingolipids, predominantly inhibits cell growth and induces apoptosis, while its metabolite, sphingosine-1-phosphate promotes growth and survival.
Michael, Maceyka +2 more
openaire +2 more sources
A fluorescence-labeled sphingosine and sphingosine 1-phosphate have been successfully synthesized from the oxazolidinone methyl ester derived from glycidol via monoalkylation and the stereoselective reduction of the resulting ketone. The labeled sphingosine was converted into its phosphate by treatment with sphingosine kinase 1 (SPHK1) from mouse, and ...
Toshikazu, Hakogi +5 more
openaire +2 more sources