Results 201 to 210 of about 84,454 (251)

Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics

Prostaglandins & Other Lipid Mediators, 2005
It has become abundantly clear over the past decade that sphingolipids and their metabolites are key signaling molecules. Ceramide, the backbone of all sphingolipids, predominantly inhibits cell growth and induces apoptosis, while its metabolite, sphingosine-1-phosphate promotes growth and survival.
Michael, Maceyka, Sheldon, Milstien, Sarah, Spiegel   +2 more
openaire   +2 more sources

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and cell death. Cer and Sph usually inhibit proliferation and promote apoptosis, while the further metabolite S1P stimulates growth and suppresses apoptosis.
Michael, Maceyka, Shawn G, Payne, Sheldon, Milstien, Sarah, Spiegel   +3 more
openaire   +2 more sources

Sphingosin und Sphingosin‐ähnliche Verbindungen

Helvetica Chimica Acta, 1959
AbstractThe syntheses of several unsaturated long‐chain aminodiols of the sphingosine type are described. Their physical properties and biological activities are noted.
E. F. Jenny, J. Druey
openaire   +1 more source

Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase)

Chemistry and Physics of Lipids, 2016
Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. Among them, sphingosine 1 phosphate (S1P) is a recognized promoter of cell survival, also involved, inter alia, in inflammation and tumorigenesis processes. The knowledge and modulation of the enzymes implicated in the biosynthesis and degradation of S1P are ...
Pol, Sanllehí, José-Luis, Abad, Josefina, Casas, Antonio, Delgado   +3 more
openaire   +2 more sources

Synthesis of fluorescence-Labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior

Bioorganic & Medicinal Chemistry Letters, 2003
A fluorescence-labeled sphingosine and sphingosine 1-phosphate have been successfully synthesized from the oxazolidinone methyl ester derived from glycidol via monoalkylation and the stereoselective reduction of the resulting ketone. The labeled sphingosine was converted into its phosphate by treatment with sphingosine kinase 1 (SPHK1) from mouse, and ...
Toshikazu, Hakogi, Toshihiko, Shigenari, Shigeo, Katsumura, Takamitsu, Sano, Takayuki, Kohno, Yasuyuki, Igarashi   +5 more
openaire   +2 more sources

Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway

2013
Sphingolipids have emerged as pleiotropic signaling molecules with roles in numerous cellular and biological functions. Defining the regulatory mechanisms governing sphingolipid metabolism is crucial in order to develop a complete understanding of the biological functions of sphingolipid metabolites.
K Alexa Orr, Gandy, Lina M, Obeid
openaire   +2 more sources

Biochemical Methods for Quantifying Sphingolipids: Ceramide, Sphingosine, Sphingosine Kinase-1 Activity, and Sphingosine-1-Phosphate

2012
Sphingolipids (ceramide, sphingosine, and sphingosine-1-phosphate) are bioactive lipids with important biological functions in proliferation, apoptosis, angiogenesis, and inflammation. Herein, we describe easy and rapid biochemical methods with the use of radiolabeled molecules ((3)H, (32)P) for their mass determination.
Leyre, Brizuela, Olivier, Cuvillier
openaire   +2 more sources