Results 61 to 70 of about 102,609 (313)

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors*

Journal of Biological Chemistry, 2002
Immunosuppressant drugs such as cyclosporin have allowed widespread organ transplantation, but their utility remains limited by toxicities, and they are ineffective in chronic management of autoimmune diseases such as multiple sclerosis. In contrast, the
V. Brinkmann, Michael D. Davis, C. Heise, R. Albert, S. Cottens, R. Hof, C. Bruns, E. Prieschl, T. Baumruker, P. Hiestand, C. A. Foster, M. Zollinger, K. Lynch   +12 more
semanticscholar   +1 more source

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Hepatic insulin resistance is a chief pathogenic determinant in the development of type 2 diabetes, which is often associated with abnormal hepatic lipid regulation.
Gulibositan Aji, Yu Huang, M. L. Ng, Wei Wang, T. Lan, Min Li, Yufei Li, Qi Chen, Rui Li, Sishan Yan, Collin L. Tran, J. Burchfield, Timothy A. Couttas, Jinbiao Chen, L. Chung, Da Liu, C. Wadham, P. Hogg, Xin Gao, M. Vadas, J. Gamble, A. Don, P. Xia, Y. Qi   +23 more
semanticscholar   +1 more source

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Sphingolipids are ubiquitous components of cell membranes and their metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important physiological functions, including regulation of cell growth and survival. Cer and Sph are associated with growth arrest and apoptosis.
Hait, Nitai C., Oskeritzian, Carole A., Paugh, Steven W., Milstien, Sheldon, Spiegel, Sarah   +4 more
openaire   +2 more sources

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. [PDF]

, 2014
BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration for treatment of patients with the relapsing-remitting form of the human demyelinating disease multiple sclerosis.
Blanc, Caroline A, Lane, Thomas E, Rosen, Hugh   +2 more
core   +1 more source

Roles of sphingosine-1-phosphate signaling in cancer

Cancer Cell International, 2019
The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in numerous cellular processes, including angiogenesis and cell survival, proliferation, and migration.
Peng Wang, Yonghui Yuan, Wenda Lin, H. Zhong, Ke Xu, Xun Qi   +5 more
semanticscholar   +1 more source

Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2

Journal of Biological Chemistry, 2020
Sphingosine has been shown to prevent and eliminate bacterial infections of the respiratory tract, but it is unknown whether sphingosine can be also employed to prevent viral infections.
M. Edwards, K. A. Becker, Barbara Gripp, M. Hoffmann, S. Keitsch, B. Wilker, Matthias Soddemann, Anne Gulbins, Elisa Carpinteiro, Sameer H. Patel, G. Wilson, S. Pöhlmann, S. Walter, K. Fassbender, Syed A. Ahmad, A. Carpinteiro, E. Gulbins   +16 more
semanticscholar   +1 more source

Sphingosine Kinase and Sphingosine 1-Phosphate in Cardioprotection [PDF]

Journal of Cardiovascular Pharmacology, 2009
Activation of sphingosine kinase/sphingosine 1-phosphate-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. Application of exogenous sphingosine 1-phosphate (S1P) in cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset ...
openaire   +2 more sources

Sphingosine kinase and sphingosine 1-phosphate in asthma

Bioscience Reports, 2010
Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell membranes, sphingolipids have emerged as sources of important signalling molecules over the past decade.
Wen-Qi, Lai, W S Fred, Wong, Bernard P, Leung   +2 more
openaire   +2 more sources

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013
Sphingosine 1-phosphate (S1P) is an important bioactive sphingolipid metabolite that has been implicated in numerous physiological and cellular processes. Not only does S1P play a structural role in cells by defining the components of the plasma membrane, but in the last 20 years it has been implicated in various significant cell signaling pathways and
K Alexa, Orr Gandy, Lina M, Obeid
openaire   +2 more sources

Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis

Journal of Lipid Research, 2006
Ceramides (Cers) accumulate within the interstices of the outermost epidermal layers, or stratum corneum (SC), where they represent critical components of the epidermal permeability barrier.
Evi Houben, Walter M. Holleran, Toshiaki Yaginuma, Cungui Mao, Lina M. Obeid, Vera Rogiers, Yutaka Takagi, Peter M. Elias, Yoshikazu Uchida   +8 more
doaj   +1 more source