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Sphingosine and Sphingosine 1 Phosphate in the Brain
2011Sphingosine is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain. It is found in sphingolipids (cerbroside, sulfatide, and ganglioside) as well as phospholipid (sphingomyelin) (Fig. 9.1). Sphingomyelin (SM) is the major membrane sphingolipid and is the precursor for ceramide and sphingosine.
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Sphingosine 1-Phosphate Breakdown in Platelets
Journal of Biochemistry, 2004We examined the formation of sphingolipid mediators in platelets, which abundantly store, and release extracellularly, sphingosine 1-phosphate (Sph-1-P). Challenging [(3)H]Sph-labeled platelet suspensions with thrombin or 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in a decrease in Sph-1-P formation and an increase in sphingosine (Sph ...
Yutaka, Yatomi +5 more
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The roles of sphingosine-1-phosphate in asthma
Molecular Immunology, 2002Asthma is a complex condition in which exposure to environmental antigens induces inflammatory reactions in the airway characterized by activation of mast cells and eosinophils. Mast cells are known to be the main effector cells in eliciting IgE-mediated allergic response.
Puneet S, Jolly +3 more
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Point-Counterpoint of Sphingosine 1-Phosphate Metabolism
Circulation Research, 2004Timothy Hla, Julie Saba
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Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate
Circulation Research, 2008, Timothy Hla, Yong-Moon Lee
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Sphingosine-1-Phosphate Induces an Antiinflammatory Phenotype in Macrophages
Circulation Research, 2008Kevin R Lynch +2 more
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