Results 91 to 100 of about 50,711 (247)

A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. [PDF]

, 2016
With the passing of Dr. Robert Bittman from pancreatic cancer on the 1st October 2014, the lipid research field lost one of the most influential and significant personalities.
Pyne, Nigel J., Tigyi, Gabor J.
core   +1 more source

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation [PDF]

Advances in Biological Regulation, 2016
Sphingosine kinase (there are two isoforms, SK1 and SK2) catalyses the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that can be released from cells to activate a family of G protein-coupled receptors, termed S1P1-5. In addition, S1P can bind to intracellular target proteins, such as HDAC1/2, to induce cell responses.
Pyne, NJ, McNaughton, M, Boomkamp, S, MacRitchie, N, EVANGELISTI, CECILIA, MARTELLI, ALBERTO MARIA, Jiang, HR, Ubhi, S, Pyne, S.   +8 more
openaire   +4 more sources

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion [PDF]

, 2017
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Cowman, Alan, Fleig, Andrea, Horgen, F. David, Malpede, Brian M, Nebl, Thomas, O\u27Neill, Joseph, Rogers, Kelly, Salinas, Nichole D, Sisquella, Xavier, Tham, Wai-Hong, Thompson, Jennifer K, Tolia, Niraj H, Whitehead, Lachlan   +12 more
core   +2 more sources

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the sphingosine-1-phosphate receptor 2 [PDF]

, 2018
OBJECTIVES: Severe pneumonia may evoke acute lung injury, and sphingosine-1-phosphate is involved in the regulation of vascular permeability and immune responses.
Bauer, Torsten T, Bertrams, Wilhelm, Dietert, Kristina, Ehrler, Carolin, Gruber, Achim D, Gutbier, Birgitt, Haberberger, Rainer, Hippenstiel, Stefan, Hocke, Andreas C, Klauschen, Frederick, Kleuser, Burkhard, Kuebler, Wolfgang M, Kummer, Wolfgang, Letsiou, Eleftheria, Lüth, Anja, Michalick, Laura, Mitchell, Timothy J, Schmeck, Bernd, Schumacher, Fabian, Schönrock, Stefanie M, Suttorp, Norbert, Szymanski, Kolja, Treue, Denise, Tönnies, Mario, Weissmann, Norbert, Witzenrath, Martin   +25 more
core   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]

, 2017
Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J., Meijer, Alexander B., Mertens, Koen, Simpson, Pelle J., van Alphen, Floris P.J., van den Biggelaar, Maartje, van den Eshof, Bart L., Zanivan, Sara   +7 more
core   +2 more sources

Lymph‐based liquid biopsy: Current progress and future potential

Interdisciplinary Medicine, EarlyView.
Recent evidence under the revised Starling principle indicates that lymph‐based liquid biopsies may offer superior diagnostic performance over blood‐based counterparts in certain clinical scenarios, such as early‐stage solid tumor detection. Currently, various biomarkers within the lymphatic system show significant diagnostic potential for a range of ...
Dongdong Liu, Leheng Cheng, Xiaolin Hu, Sergio Bernardini, Hong Zhang, Ling Zhu, Yang Luo   +6 more
wiley   +1 more source

Antagonizing the S1P-S1P3 Axis as a Promising Anti-Angiogenic Strategy

Metabolites
Background: Angiogenesis, the process of new blood vessel formation, is critically regulated by a balance of pro- and anti-angiogenic factors. This process plays a central role in tumor progression and is modulated by tumor cells. Sphingosine-1-phosphate
Sofia Avnet, Emi Mizushima, Beatrice Severino, Maria Veronica Lipreri, Antonia Scognamiglio, Angela Corvino, Nicola Baldini, Margherita Cortini   +7 more
doaj   +1 more source