Results 81 to 90 of about 31,038,445 (201)

Generierung von Sphingosin-1-Phosphat durch apoptotische Zellen und dessen Einfluss auf die Polarisierung von Makrophagen während der Tumorentwicklung [PDF]

, 2008
The removal of apoptotic cells (AC) can be regarded as an integral component of the program to terminate inflammation. Clearance of AC by professional phagocytes such as macrophages induces an anti-inflammatory phenotype in the latter ones.
Weigert, Andreas
core  

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source

Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis [PDF]

, 2013
PMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
I. Mavrommati, Piñeiro R, Chiozzotto, D, Tania Maffucci, G. Tibolla, Pineiro, R, Wheeler Ann P., Giuseppe Danilo Norata (104795), Wheeler, A., Ioanna Mavrommati, Maffucci Tania, Norata, G., Chiozzotto Daniela, Ioanna Mavrommati (104788), Tibolla Gianpaolo, Mavrommati, I, Maffucci, T, D. Chiozzotto, Falasca, M, Mavrommati Ioanna, Alberico Luigi Catapano, Roberto Piñeiro (104782), Mavrommati, I., Daniela Chiozzotto, Ann P Wheeler, R. Piñeiro, Gianpaolo Tibolla (104779), Norata GD, G.D. Norata, Norata Giuseppe Danilo, M. Falasca, Giuseppe Danilo Norata, Daniela Chiozzotto (104784), T. Maffucci, Catapano AL, Ann P. Wheeler (104791), Falasca Marco, Piñeiro Roberto, A.L. Catapano, Marco Falasca (104805), Chiozzotto D, Alberico Luigi Catapano (104799), Falasca, Marco, Wheeler AP, Falasca M, Maffucci T, Catapano, A., Mavrommati I, Norata, GD, Tibolla G, Piñeiro, R., Chiozzotto, D., Marco Falasca, Maffucci, T., Tibolla, G., Tibolla, G, Wheeler, AP, Roberto Piñeiro, Catapano Alberico Luigi, A. P. Wheeler, Gianpaolo Tibolla, Catapano, AL, Tania Maffucci (104802)   +62 more
core   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Sphingosine 1-phosphate signalling in mammalian cells [PDF]

, 2000
Sphingosine 1-phosphate is formed in cells in response to diverse stimuli, including growth factors, cytokines, G-protein-coupled receptor agonists, antigen, etc. Its production is catalysed by sphingosine kinase, while degradation is either via cleavage
Nigel J. PYNE, Susan PYNE, Pyne, S, Pyne, N J   +3 more
core   +1 more source

A guide to selecting high-performing antibodies for S1PR1 (UniProt ID: P21453) for use in western blot, immunoprecipitation, and immunofluorescence [version 3; peer review: 2 approved, 1 approved with reservations]

F1000Research
Sphingosine 1-phosphate receptor 1 (S1PR1) is a G-coupled protein receptor that induces crucial biological processes when bound by sphingosine 1-phosphate. Here, we have characterized nine S1PR1 commercial antibodies for western blot, immunoprecipitation,
Carl Laflamme, Sara González Bolívar, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Charles Alende   +5 more
doaj   +1 more source

Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study

Frontiers in Immunology, 2017
Systemic sclerosis (SSc) is a rare multi-organ autoimmune disease characterized by progressive skin fibrosis. Inflammation, type 2 immunity, and fibrogenic processes are involved in disease development and may be affected by sphingolipids.
Katrin G. Schmidt, Martina Herrero San Juan, Sandra Trautmann, Lucija Berninger, Anja Schwiebs, Florian M. Ottenlinger, Dominique Thomas, Frank Zaucke, Josef M. Pfeilschifter, Heinfried H. Radeke   +9 more
doaj   +1 more source

Clinical Trial: Dupilumab Improves Eosinophilic Oesophagitis Outcomes Versus Placebo Regardless of Comorbidities or Treatment History in a Randomised Clinical Trial

Alimentary Pharmacology &Therapeutics, EarlyView.
Dupilumab improved all histological, symptomatic, and endoscopic outcomes assessed at Week 24 versus placebo in patients with eosinophilic oesophagitis, regardless of demographics, disease characteristics, treatment history, or type 2 inflammatory disease comorbidities.
Evan S. Dellon, Marc E. Rothenberg, Jonathan M. Spergel, Albert J. Bredenoord, Antonella Cianferoni, Changming Xia, Margee Louisias, Allen Radin   +7 more
wiley   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source