Results 11 to 20 of about 29,323 (206)

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy

Epilepsia Open
Epilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li   +4 more
doaj   +3 more sources

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer [PDF]

Discover Oncology, 2021
AbstractSphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell proliferation, survival, drug resistance, metastasis, and angiogenesis. S1P is formed by two sphingosine kinases (SphKs), SphK1 and SphK2. The intracellularly produced S1P is delivered to the extracellular
Guangmeng Xu, Zecheng Yang, Yamin Sun, Hongmei Dong, Jingru Ma   +4 more
openaire   +3 more sources

Sphingosine-1-phosphate receptor 2 [PDF]

FEBS Journal, 2013
Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid involved in cell proliferation, angiogenesis, inflammation and malignant transformation among other functions. S1P acts either directly on intracellular targets or activates G protein-coupled receptors, specifically five S1P receptors (S1PRs).
Mohamad, Adada, Daniel, Canals, Yusuf A, Hannun, Lina M, Obeid   +3 more
openaire   +2 more sources

Structural Insights into Sphingosine-1-phosphate Receptor Activation [PDF]

Proceedings of the National Academy of Sciences, 2022
Abstract As a critical sphingolipid metabolite, sphingosine-1-phosphate (S1P) plays an essential role in immune and vascular systems. There are five S1P receptors, designated as S1PR1-5, encoded in the human genome, and their activities are governed by endogenous S1P, lipid-like S1P mimics, or non-lipid-like ...
Leiye Yu, Licong He, Bing Gan, Rujuan Ti, Qingjie Xiao, Xin Yang, Hongli Hu, Lizhe Zhu, Sheng Wang, Ruobing Ren   +9 more
openaire   +2 more sources

Sphingosine-1-phosphate receptor signalling in the heart [PDF]

Cardiovascular Research, 2008
The five known members of the sphingosine-1-phosphate (S1P) receptor family exhibit diverse tissue expression profiles and couple to distinct G-protein-mediated signalling pathways. S1P1, S1P2, and S1P3 receptors are all present in the heart, but the ratio of these subtypes differs for various cardiac cells. The goal of this review is to summarize data
Christopher K, Means, Joan Heller, Brown
openaire   +2 more sources

Structure of the First Sphingosine 1-Phosphate Receptor [PDF]

Science Signaling, 2012
The lipid sphingosine 1-phosphate may laterally diffuse through the membrane to bind a receptor.
Abby L, Parrill, Santiago, Lima, Sarah, Spiegel   +2 more
openaire   +2 more sources

G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

Stem Cell Research & Therapy, 2022
Background The bone marrow niche supports hematopoietic cell development through intimate contact with multipotent stromal mesenchymal stem cells; however, the intracellular signaling, function, and regulation of such supportive niche cells are still ...
Jaime M. Brozowski, Roman G. Timoshchenko, D. Stephen Serafin, Brittney Allyn, Jessica Koontz, Emily M. Rabjohns, Rishi R. Rampersad, Yinshi Ren, Amanda M. Eudy, Taylor F. Harris, David Abraham, Daniel Mattox, Clinton T. Rubin, Matthew J. Hilton, Janet Rubin, Nancy L. Allbritton, Matthew J. Billard, Teresa K. Tarrant   +17 more
doaj   +1 more source

Modulators of the Sphingosine 1-phosphate receptor 1 [PDF]

Bioorganic & Medicinal Chemistry Letters, 2013
The Sphingosine 1-phosphate receptor (S1P-R) signaling system has proven to be of biological and medical importance in autoimmune settings. S1P1-R is a validated drug target for multiple sclerosis (MS) for which FTY720 (Fingolimod), a S1P1,3-5-R pan-agonist, was recently approved as the first orally active drug for the treatment of relapsing-remitting ...
Mariangela, Urbano, Miguel, Guerrero, Hugh, Rosen, Edward, Roberts   +3 more
openaire   +2 more sources

Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases

Liver Research, 2019
The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitioning. Obesity, dyslipidemia and metabolic disorders are of increasing public health concern worldwide, and ...
Eric K. Kwong, Huiping Zhou
doaj   +1 more source

High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists. [PDF]

PLoS ONE, 2014
HDL carries biologically active lipids such as sphingosine-1-phosphate (S1P) and stimulates a variety of cell signaling pathways in diverse cell types, which may contribute to its ability to protect against atherosclerosis.
Aishah Al-Jarallah, Xing Chen, Leticia González, Bernardo L Trigatti   +3 more
doaj   +1 more source