Results 11 to 20 of about 31,038,445 (201)

Fingolimod modulates microglial activation to augment markers of remyelination [PDF]

Journal of Neuroinflammation, 2011
Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell ...
Baker David, Giovannoni Gavin, Jackson Samuel J   +2 more
doaj   +2 more sources

Impaired Sphingosine-1-Phosphate Synthesis Induces Preeclampsia by Deactivating Trophoblastic YAP (Yes-Associated Protein) Through S1PR2 (Sphingosine-1-Phosphate Receptor-2)-Induced Actin Polymerizations [PDF]

, 2021
Incomplete spiral artery remodeling, caused by impaired extravillous trophoblast invasion, is a fundamental pathogenic process associated with malplacentation and the development of preeclampsia.
Yue Wu (1262184), Mingyu Hu (2177308), Li Lin (111038), Louise C Kenny (10123735), Mark D Kilby (8483634), Jiayu Huang (3408389), Chao Tong (389167), Huijia Fu (8719995), Li Wen (169316), Yangxi Zheng (8654490), Philip N Baker (7724603), Hongbo Qi (1370292), Biao Huang (215504), Sisi Li (437128), Xuan Ye (1817743), Yong Fu (699744), Jiujiang Liao (8654865), Ping Xu (122619), Ran Duan (821258), Xiyao Liu (5736281)   +19 more
core   +8 more sources

Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase [PDF]

, 2011
Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade.
Gorshkova, Irina, Usatyuk, Peter, Sabbadini, Roger A, Natarajan, Viswanathan, Kalari, Satish, Pyne, Nigel J, Pyne, Susan, Berdyshev, Evgeny V, Zhao, Yutong, Garcia, Joe G.N.   +9 more
core   +4 more sources

G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

Stem Cell Research & Therapy, 2022
Background The bone marrow niche supports hematopoietic cell development through intimate contact with multipotent stromal mesenchymal stem cells; however, the intracellular signaling, function, and regulation of such supportive niche cells are still ...
Jaime M. Brozowski, Roman G. Timoshchenko, D. Stephen Serafin, Brittney Allyn, Jessica Koontz, Emily M. Rabjohns, Rishi R. Rampersad, Yinshi Ren, Amanda M. Eudy, Taylor F. Harris, David Abraham, Daniel Mattox, Clinton T. Rubin, Matthew J. Hilton, Janet Rubin, Nancy L. Allbritton, Matthew J. Billard, Teresa K. Tarrant   +17 more
doaj   +1 more source

Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases

Liver Research, 2019
The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitioning. Obesity, dyslipidemia and metabolic disorders are of increasing public health concern worldwide, and ...
Eric K. Kwong, Huiping Zhou
doaj   +1 more source

High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists. [PDF]

PLoS ONE, 2014
HDL carries biologically active lipids such as sphingosine-1-phosphate (S1P) and stimulates a variety of cell signaling pathways in diverse cell types, which may contribute to its ability to protect against atherosclerosis.
Aishah Al-Jarallah, Xing Chen, Leticia González, Bernardo L Trigatti   +3 more
doaj   +1 more source

Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells.

PLoS ONE, 2014
Given that the bioactive lipid sphingosine 1-phosphate is involved in cardiovascular pathophysiology, and since lipid accumulation and inflammation are hallmarks of calcific aortic stenosis, the role of sphingosine 1-phosphate on the pro-inflammatory/pro-
Isabel Fernández-Pisonero, Javier López, Esther Onecha, Ana I Dueñas, Patricia Maeso, Mariano Sánchez Crespo, José Alberto San Román, Carmen García-Rodríguez   +7 more
doaj   +1 more source

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
Kleuser, Burkhard (Prof. Dr. rer. nat.), Radeke, Heinfried H., Japtok, Lukasz, Heinfried H Radeke, Kleuser, Burkhard, Jeong, Se Kyoo, Wolfgang Bäumer, Burkhard Kleuser, Katrin Schaper, Heinfried H. Radeke, Schaper, Katrin, Lukasz Japtok, Bäumer, Wolfgang, Se Kyoo Jeong   +13 more
core   +1 more source

Sphingosine 1-phosphate in renal diseases [PDF]

, 2013
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Pfeilschrifter, Josef, Koch, Alexander, Alexander Koch, Josef Pfeilschifter, Pfeilschifter, Josef, Huwiler, Andrea, Andrea Huwiler   +6 more
core   +2 more sources

Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells

Frontiers in Molecular Biosciences, 2021
Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine.
Ling-Wei Hii, Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong, Chee-Onn Leong   +7 more
doaj   +1 more source