Results 31 to 40 of about 31,038,445 (201)

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2*

Journal of Lipid Research, 2009
Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells in the liver, and inhibits proliferation via S1P receptor 2 (S1P2) in hepatocytes in ...
Hitoshi Ikeda, Naoko Watanabe, Isao Ishii, Tatsuo Shimosawa, Yukio Kume, Tomoaki Tomiya, Yukiko Inoue, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Satoko Iitsuka, Ryoto Fujita, Masao Omata, Jerold Chun, Yutaka Yatomi   +14 more
doaj   +1 more source

Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator [PDF]

, 2011
Sphingosine-1-phosphate (S1P) acts as high affinity agonist at specific G-protein-coupled receptors, S1P(1-5), that play important roles e.g. in the cardiovascular and immune systems.
Bianca Hegen, van Echten-Deckert, Gerhild, Huwiler, Andrea, Dagmar Meyer zu Heringdorf, Sandra Labocha, Michael ter Braak, Heringdorf, Dagmar Meyer Zu, Gerhild van Echten-Deckert, Labocha, Sandra, Ferreirós, Nerea, Meyer Zu Heringdorf, Dagmar, Ter Braak, Michael, Josef Pfeilschifter, Pfeilschifter, Josef, Nerea Ferreirós, Ralf Frederik Claas, Hegen, Bianca, Andrea Huwiler, Claas, Ralf Frederik   +18 more
core   +1 more source

Redox‐Neutral Vicinal Dialkylation of Aryl Boronic Esters via the Palladium/Norbornene Cooperative Catalysis

Angewandte Chemie, EarlyView.
A new mode of the palladium/norbornene (Pd/NBE) cooperative catalysis, that is, redox‐neutral difunctionalization of aryl boronic esters with two electrophiles, has been developed, which can be used to streamline the preparation of a functionalized benzoazepane.
Rong Ye, Peimiao He, Liyan Kan, Thomas R. Plambeck, Guangbin Dong   +4 more
wiley   +2 more sources

S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung

Acta Pharmaceutica Sinica B, 2023
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unclear etiology and limited treatment options. The median survival time for IPF patients is approximately 2–3 years and there is no effective intervention to treat IPF other than ...
Mengyao Hao, Rong Fu, Jun Tai, Zhenhuan Tian, Xia Yuan, Yang Chen, Mingjin Wang, Huimin Jiang, Ming Ji, Fangfang Lai, Nina Xue, Liping Bai, Yizhun Zhu, Xiaoxi Lv, Xiaoguang Chen, Jing Jin   +15 more
doaj   +1 more source

Antinociceptive activity of the S1P-receptor agonist FTY720 [PDF]

, 2008
FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist.
Geisslinger, Gerd, Gerd Geisslinger, Scholich, Klaus, Angioni, Carlo Federico, Klaus Scholich, Laura Popp, Sandra Pierre, Brenneis, Christian, Ovidiu Coste, Claudiu Marian, Marian, Claudiu, Popp, Laura, Coste, Ovidiu, Carlo Angioni, Schmidt, Helmut, Christian Brenneis, Pierre, Sandra, Helmut Schmidt   +17 more
core   +1 more source

Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection [PDF]

, 2011
High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the ...
Hacking, Damian
core   +1 more source

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy

Epilepsia Open
Epilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li   +4 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source