Results 21 to 30 of about 29,323 (206)

An update on the biology of sphingosine 1-phosphate receptors [PDF]

Journal of Lipid Research, 2014
Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily as an ex-tracellular signaling molecule. Signals initiated by S1P are transduced by five G protein-coupled receptors, named S1P1-5 Cellular and temporal expression of the S1P receptors (S1PRs) determine their specific roles in various organ systems, but they are ...
Victoria A. Blaho, Timothy Hla
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Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells.

PLoS ONE, 2014
Given that the bioactive lipid sphingosine 1-phosphate is involved in cardiovascular pathophysiology, and since lipid accumulation and inflammation are hallmarks of calcific aortic stenosis, the role of sphingosine 1-phosphate on the pro-inflammatory/pro-
Isabel Fernández-Pisonero, Javier López, Esther Onecha, Ana I Dueñas, Patricia Maeso, Mariano Sánchez Crespo, José Alberto San Román, Carmen García-Rodríguez   +7 more
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Sphingosine-1-phosphate receptors and innate immunity [PDF]

Cellular Microbiology, 2018
Sphingosine-1-phosphate (S1P) is a signalling lipid that regulates many cellular processes in mammals. One well-studied role of S1P signalling is to modulate T-cell trafficking, which has a major impact on adaptive immunity. Compounds that target S1P signalling pathways are of interest for immune system modulation.
Arielle M. Bryan, Maurizio Del Poeta
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Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells

Frontiers in Molecular Biosciences, 2021
Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine.
Ling-Wei Hii, Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong, Chee-Onn Leong   +7 more
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Sphingosine 1-Phosphate Receptor 4 Expression in Colorectal Cancer Patients

Walailak Journal of Science and Technology, 2016
The aim of this study was to investigate the expression of S1PR4 in colorectal cancer and its correlation with clinicopathologic characteristics. Paraffin-embedded colorectal cancer samples and matched adjacent normal tissues were collected from 32 ...
Suchittra SAMUHASANEETO, Suthiporn PROMAGSORN, Chuchard PUNSAWAD   +2 more
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Targeting Sphingosine-1-Phosphate Receptors in Cancer [PDF]

Anti-Cancer Agents in Medicinal Chemistry, 2011
Sphingosine 1-phosphate (S1P) is a bioactive lipid with diverse biological functions, including cell proliferation, differentiation, angiogenesis, chemotaxis, and migration. Many of the activities of S1P are mediated through five closely related G-protein-coupled receptors of the sphingosine-1-phosphate receptor family (S1PR) which play a crucial role ...
Rebecca J, Watters, Hong-Gang, Wang, Shen-Shu, Sung, Thomas P, Loughran, Xin, Liu   +4 more
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In silico Docking Studies of Fingolimod and S1P1 Agonists

Frontiers in Pharmacology, 2020
The sphingosine-1-phosphate receptor 1 (S1P1), originally the endothelial differentiation gene 1 receptor (EDG-1), is one of five G protein–coupled receptors (GPCRs) S1P1–5 that bind to and are activated by sphingosine-1-phosphate (S1P). The lipid S1P is
Alexander Marciniak, Sara M. Camp, Joe G. N. Garcia, Robin Polt   +3 more
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Sphingosine 1-Phosphate Analogs as Receptor Antagonists [PDF]

Journal of Biological Chemistry, 2005
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cell and tissue responses via a set of cell surface receptors. The recent development of S1P receptor agonists, led by the immunomodulatory pro-drug FTY720, has revealed that S1P signaling is an important regulator of lymphocyte trafficking.
Michael D, Davis, Jeremy J, Clemens, Timothy L, Macdonald, Kevin R, Lynch   +3 more
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Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain

Cell Reports, 2020
Summary: In the adult brain, new dentate granule cells integrate into neural circuits and participate in hippocampal functioning. However, when and how they initiate this integration remain poorly understood. Using retroviral and live-imaging methods, we
Chih-Hao Yang, Adrian Di Antonio, Gregory W. Kirschen, Parul Varma, Jenny Hsieh, Shaoyu Ge   +5 more
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Structural determinants of sphingosine‐1‐phosphate receptor selectivity

Archiv der Pharmazie, 2023
AbstractFingolimod, the prodrug of fingolimod‐1‐phosphate (F1P), was the first sphingosine‐1‐phosphate receptor (S1PR) modulator approved for multiple sclerosis. F1P unselectively targets all five S1PR subtypes. While agonism (functional antagonism via receptor internalization) at S1PR1 leads to the desired immune modulatory effects, agonism at S1PR3 ...
Friederike Wunsch, Trung Ngoc Nguyen, Gerhard Wolber, Marcel Bermudez   +3 more
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