Results 151 to 160 of about 371,184 (271)
Journal of Gastroenterology and Hepatology, Volume 41, Issue 2, Page 686-695, February 2026.ABSTRACT Background Aberrant T‐helper 1 (Th1) and Th17 cell activation is involved in the pathogenesis of inflammatory bowel disease (IBD). Psychosine is known to induce apoptosis, promote astrocyte activation, and inhibit osteoclastogenesis. However, the role of psychosine on Th1 and Th17 cell immune responses has not been previously reported. In this
Ritian Lin +4 more
wiley +1 more source
Cancer Cell InternationalPancreatic cancer is known to be the most lethal cancer. Fewer new treatments are being developed for pancreatic cancer as compared to other cancers. The bioactive lipid S1P, which is mainly regulated by sphingosine kinase 1 (SK1) and sphingosine kinase ...
Khem Raj Limbu +6 more
doaj +1 more source
European Journal of Histochemistry, 2018 A concomitant action of multiple profibrotic mediators appears crucial in the development and progression of fibrosis. Sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-β/Smads pathways are both involved in pathogenesis of ...
Roberta Sferra +7 more
doaj +1 more source
A Somatic Mutation in HIF‐2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.A mutation within the C‐terminal transactivation domain of HIF‐2α enhances Cd36 expression by increased transactivation activity, leading to ceramide accumulation and disruption of glucose and lipid metabolism. Inhibition of ceramide synthesis by myriocin reduces ceramide levels and ameliorates these metabolic disturbances.
Feiqiong Gao +9 more
wiley +1 more source
OncoTarget, 2016 The infiltration of melanoma tumors by macrophages is often correlated with poor prognosis. However, the molecular signals that regulate the dialogue between malignant cells and the inflammatory microenvironment remain poorly understood.
Marguerite Mrad +12 more
semanticscholar +1 more source
Flow dynamics control the effect of sphingosine-1-phosphate on endothelial permeability in a microfluidic vessel bifurcation model [PDF]
, 2018 Blood vessels are lined by endothelial cells that form a semipermeable barrier to restrict fluid flow across the vessel wall. The endothelial barrier is known to respond to various molecular mechanisms, but the effects of mechanical signals that arise ...
Spychalski, Griffin
core
Scientific Reports, 2016 The role of sphingosine 1-phosphate (S1P) in liver fibrosis or inflammation was not fully examined in human. Controversy exists which S1P receptors, S1P1 and S1P3 vs S1P2, would be importantly involved in its mechanism.
Masaya Sato +10 more
semanticscholar +1 more source
Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis
World Journal of Biological Chemistry, 2010 The importance of sphingosine kinase (SphK) and sphingosine-1-phosphate (S1P) in inflammation has been extensively demonstrated. As an intracellular second messenger, S1P plays an important role in calcium signaling and mobilization, and cell proliferation and survival.
Wen-Qi, Lai +2 more
openaire +2 more sources
Targeting sphingosine kinase 1 in p53KO thymic lymphoma. [PDF]
FASEB J, 2023 Velazquez FN +7 more
europepmc +1 more source
UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1. [PDF]
Cells, 2023 Epshtein Y +3 more
europepmc +1 more source