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Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and cell death. Cer and Sph usually inhibit proliferation and promote apoptosis, while the further metabolite S1P stimulates growth and suppresses apoptosis.
Michael, Maceyka +3 more
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Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics
Prostaglandins & Other Lipid Mediators, 2005It has become abundantly clear over the past decade that sphingolipids and their metabolites are key signaling molecules. Ceramide, the backbone of all sphingolipids, predominantly inhibits cell growth and induces apoptosis, while its metabolite, sphingosine-1-phosphate promotes growth and survival.
Michael, Maceyka +2 more
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Chemistry and Physics of Lipids, 2016
Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. Among them, sphingosine 1 phosphate (S1P) is a recognized promoter of cell survival, also involved, inter alia, in inflammation and tumorigenesis processes. The knowledge and modulation of the enzymes implicated in the biosynthesis and degradation of S1P are ...
Pol, Sanllehí +3 more
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Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. Among them, sphingosine 1 phosphate (S1P) is a recognized promoter of cell survival, also involved, inter alia, in inflammation and tumorigenesis processes. The knowledge and modulation of the enzymes implicated in the biosynthesis and degradation of S1P are ...
Pol, Sanllehí +3 more
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Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway
2013Sphingolipids have emerged as pleiotropic signaling molecules with roles in numerous cellular and biological functions. Defining the regulatory mechanisms governing sphingolipid metabolism is crucial in order to develop a complete understanding of the biological functions of sphingolipid metabolites.
K Alexa Orr, Gandy, Lina M, Obeid
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Targeting sphingosine kinase 1 in cancer
Advances in Biological Regulation, 2012Cancer is one of largest killers in the world and defeating it represents one of the most important challenges in Medicine today. For instance, annually, around 1.38 million women are diagnosed worldwide with breast cancer and approximately 0.25 million men worldwide are diagnosed with prostate and testicular cancer.
Pyne, Nigel J +5 more
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Sphingosine kinase 1 in viral infections
Reviews in Medical Virology, 2012SUMMARYSphingosine kinase 1 (SphK1) is an enzyme that phosphorylates the lipid sphingosine to generate sphingosine‐1‐phosphate (S1P). S1P can act intracellularly as a signaling molecule and extracellularly as a receptor ligand. The SphK1/S1P axis has well‐described roles in cell signaling, the cell death/survival decision, the production of a pro ...
Carr, J. +3 more
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Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2
Bioorganic & Medicinal Chemistry Letters, 2004Fluorescently labeled d-erythro-sphingosines have been successfully synthesized in 9 and 12 steps starting from commercially available Garner aldehyde. Determining the influence of the nature, position and linkage of the label on the in vitro phosphorylation rate by sphingosine kinases 1 and 2 resulted in the identification of a pyrene- and a NBD ...
Peter, Ettmayer +5 more
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Sphingosine kinase activity and sphingosine‐1‐phosphate in the inflamed human periodontium
Oral Diseases, 2021Abstract Objectives This study evaluated changes in the levels of Sphingosine‐1‐Phosphate (S1P) and Sphingosine Kinase (SPHK) activity in response to non‐surgical periodontal treatment in humans. Methods
Nader Hamdan +2 more
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Activation of Sphingosine Kinase 1
2006Sphingosine-1-phosphate (S1P) is a potent bioactive lipid that regulates many important biological processes as a ligand for cell surface receptors and as an intracellular second messenger. S1P levels inside cells are regulated in a temporal and spatial manner by the balance between its formation, catalyzed by two sphingosine kinase isoenzymes, SphK1 ...
Michael Maceyka +3 more
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Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system
Cellular Signalling, 2009Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells.
Taro, Okada +3 more
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