Results 161 to 170 of about 30,319,267 (183)

[Sphingosine kinase-1 regulates migration and invasion of gastric cancer cells via targeting the nuclear factor-κB signaling pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Ling Q, Ji K, Chen J, Guan J, Wang R, Man W, Zhu B.   +6 more
europepmc   +1 more source

Expression of Concern: miRNA-103 promotes chondrocyte apoptosis by downregulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis. [PDF]

Biosci Rep
europepmc   +1 more source

Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model.

Am J Physiol Lung Cell Mol Physiol
Sudhadevi T, Ackerman SJ, Jafri A, Basa P, Ha AW, Natarajan V, Harijith A.   +6 more
europepmc   +1 more source

Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

British Journal of Pharmacology, 2012
Sphingosine kinase 1 catalyses formation of the bioactive lipid, sphingosine 1-phosphate, which protects cancer cells from apoptosis. Therefore, sphingosine kinase 1 is a novel target for intervention with anti-cancer agents.
Nigel J Pyne, Susan Pyne, Keng Gat Lim
exaly   +5 more sources

Activation of sphingosine kinase 1 by ERK1/2‐mediated phosphorylation [PDF]

EMBO Journal, 2003
Copyright © 2003 European Molecular Biology OrganizationSphingosine kinase 1 is an agonist-activated signalling enzyme that catalyses the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of agonist ...
Stuart M Pitson, Pu Xia, Paul Moretti
exaly   +2 more sources

Functional characterization of human sphingosine kinase-1 [PDF]

FEBS Letters, 2000
Sphingosine kinase catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a novel lipid mediator with both intra- and extracellular functions.
Sarah Spiegel, Víctor E Nava, Takafumi Kohama   +2 more
exaly   +2 more sources

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer

International Journal of Molecular Sciences, 2017
Sphingosine kinase 1 (Sphk1) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). Growing studies have demonstrated that Sphk1 is overexpressed in various types of solid cancers and can be induced by ...
Wancai Yang
exaly   +2 more sources

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Sphingosine kinase inhibitors: a review of patent literature (2006-2015)

Expert Opinion on Therapeutic Patents, 2016
Webster L Santos, Kevin R Lynch
exaly  

Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity

Lipids and Lipid Metabolism, 1996
R M Bell, Robert M Bell
exaly  

Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice

FEBS Letters, 2006
Timothy Hla, Richard L. Proia, Masataka Kohno   +2 more
exaly