Results 161 to 170 of about 371,184 (271)

Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans

Mediators of Inflammation, 2015
Glycosphingolipids (GSLs) are composed of hydrophobic ceramide and hydrophilic sugar chains. GSLs cluster to form membrane microdomains (lipid rafts) on plasma membranes, along with several kinds of transducer molecules, including Src family kinases and ...
Kazuhisa Iwabuchi, Hitoshi Nakayama, Ami Oizumi, Yasushi Suga, Hideoki Ogawa, Kenji Takamori   +5 more
doaj   +1 more source

Molecular docking analysis of sphingosine kinase 1 inhibitors for cancer management. [PDF]

Bioinformation, 2023
Barnawi J.
europepmc   +1 more source

Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes. [PDF]

J Lipid Res, 2023
Morishige JI, Yoshioka K, Nakata H, Ishimaru K, Nagata N, Tanaka T, Takuwa Y, Ando H.   +7 more
europepmc   +1 more source

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence. [PDF]

, 2019
Although aging is considered to be an unavoidable event, recent experimental evidence suggests that the process can be counteracted. Intracellular calcium (Ca2+i) dyshomeostasis, mitochondrial dysfunction, oxidative stress, and lipid dysregulation are ...
Bomba, Manuela, Castelli, Vanessa, Cicalini, Ilaria, Cimini, Annamaria, d'Aurora, Marco, Del Boccio, Piero, Gatta, Valentina, Granzotto, Alberto, Massetti, Noemi, Navarra, Riccardo, Onofrj, Marco, Piomelli, Daniele, Sensi, Stefano L   +12 more
core  

P652The cardioprotective effect of exogenous sphingosine-1-phosphate requires the activation of endogenous sphingosine-1-phosphate via the sphingosine kinase 1 [PDF]

, 2017
Purpose: Exogenous administration of sphingosine-1-phosphate (S1P) alone, or as part of high density lipoprotein, protects against myocardial infarction.
Frias, MA, James, RW, Lecour, S., Pedretti, S.   +3 more
core  

Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells. [PDF]

PLoS Pathog, 2023
Fohmann I, Weinmann A, Schumacher F, Peters S, Prell A, Weigel C, Spiegel S, Kleuser B, Schubert-Unkmeir A.   +8 more
europepmc   +1 more source

Sphingosine Kinase 1 [PDF]

, 2020
openaire   +1 more source

The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib

Current Research in Pharmacology and Drug Discovery
Non-small-cell lung cancer (NSCLC) represents a predominant histological subtype of lung cancer, characterized by high incidence and mortality rates.
Jing Zhang, Zequn Wang, Xihua Wei, Mengyuan Han, Ribai Yan, Lijie Ma, Yan Pan   +6 more
doaj   +1 more source

Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail. [PDF]

FASEB J, 2023
Bonica J, Clarke CJ, Obeid LM, Luberto C, Hannun YA.   +4 more
europepmc   +1 more source

Feline mammary carcinoma-derived extracellular vesicle promotes liver metastasis via sphingosine kinase-1-mediated premetastatic niche formation. [PDF]

Lab Anim Res, 2023
Chang YC, Liu HP, Chuang HL, Liao JW, Kao PL, Chan HL, Chen TH, Wang YC.   +7 more
europepmc   +1 more source