Spider-Venom Peptides as Therapeutics [PDF]
Toxins, 2010 Spiders are the most successful venomous animals and the most abundant terrestrial predators. Their remarkable success is due in large part to their ingenious exploitation of silk and the evolution of pharmacologically complex venoms that ensure rapid ...
Glenn F. King +6 more
doaj +4 more sources
Biotechnological Trends in Spider and Scorpion Antivenom Development [PDF]
Toxins, 2016 Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain.
Andreas Hougaard Laustsen +5 more
doaj +12 more sources
Quo Vadis Venomics? A Roadmap to Neglected Venomous Invertebrates [PDF]
Toxins, 2014 Venomics research is being revolutionized by the increased use of sensitive -omics techniques to identify venom toxins and their transcripts in both well studied and neglected venomous taxa.
Bjoern Marcus von Reumont +2 more
doaj +3 more sources
Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications
Molecules, 2023 Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity, with 47,000 described species and an estimated 150,000 species in existence. Evolving with intricate venom, spiders are nature’s skilled predators.
Ruiyin Guo +5 more
doaj +1 more source
Venom of the Brazilian spider Sicarius ornatus (Araneae, Sicariidae) contains active sphingomyelinase D: potential for toxicity after envenomation. [PDF]
PLoS Neglected Tropical Diseases, 2013 BACKGROUND:The spider family Sicariidae includes two genera, Sicarius and Loxosceles. Bites by Sicarius are uncommon in humans and, in Brazil, a single report is known of a 17-year old man bitten by a Sicarius species that developed a necrotic lesion ...
Priscila Hess Lopes +5 more
doaj +1 more source
A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5
Frontiers in Pharmacology, 2021 Spider venoms include various peptide toxins that modify the ion currents, mainly of excitable insect cells. Consequently, scientific research on spider venoms has revealed a broad range of peptide toxins with different pharmacological properties, even ...
Diana Alvarado +13 more
doaj +1 more source
Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents. [PDF]
Biochem Res IntGlioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Santiago LR +5 more
europepmc +2 more sources
Comparative venomic profiles of three spiders of the genus Phoneutria
Journal of Venomous Animals and Toxins including Tropical Diseases, 2022 Background: Spider venoms induce different physio-pharmacological effects by binding with high affinity on molecular targets, therefore being of biotechnological interest.
Frederico Francisco Fernandes +9 more
doaj +1 more source
A novel neurotoxin from venom of the spider, Brachypelma albopilosum. [PDF]
PLoS ONE, 2014 Spiders have evolved highly selective toxins for insects. There are many insecticidal neurotoxins in spider venoms. Although a large amount of work has been done to focus on neurotoxicity of spider components, little information, which is related with ...
Yunhua Zhong +7 more
doaj +1 more source
Spider-Venom Peptides as Bioinsecticides [PDF]
Toxins, 2012 Over 10,000 arthropod species are currently considered to be pest organisms. They are estimated to contribute to the destruction of ~14% of the world’s annual crop production and transmit many pathogens. Presently, arthropod pests of agricultural and health significance are controlled predominantly through the use of chemical insecticides ...
Monique J. Windley +5 more
openaire +4 more sources