Results 21 to 30 of about 412,161 (357)
Frontiers in Cell and Developmental Biology, 2021 The nuclear mitotic apparatus (NuMA) protein is well conserved in vertebrates, and dynamically changes its subcellular localization from the interphase nucleus to the mitotic/meiotic spindle poles and the mitotic cell cortex.
Tomomi Kiyomitsu, Susan Boerner
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eLife, 2020 Asymmetric astral microtubule organization drives the polarized orientation of the S. cerevisiae mitotic spindle and primes the invariant inheritance of the old spindle pole body (SPB, the yeast centrosome) by the bud.
Marco Geymonat +6 more
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The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals
eLife, 2022 Proteins associated with the spindle apparatus, a cytoskeletal structure that ensures the proper segregation of chromosomes during cell division, experienced an unusual number of amino acid substitutions in modern humans after the split from the ...
Stéphane Peyrégne +3 more
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eLife, 2022 During cell division, the spindle generates force to move chromosomes. In mammals, microtubule bundles called kinetochore-fibers (k-fibers) attach to and segregate chromosomes. To do so, k-fibers must be robustly anchored to the dynamic spindle.
Pooja Suresh +3 more
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Human spindle variability [PDF]
The Journal of Neuroscience, 2021 AbstractIn humans, sleep spindles are 10-16 Hz oscillations lasting approximately 0.5-2 s. Spindles, along with cortical slow oscillations, facilitate memory consolidation by enabling synaptic plasticity. Early recordings of spindles at the scalp found anterior channels had overall slower frequency than central-posterior channels.
Christopher Gonzalez +5 more
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Current Biology, 2018 Schönauer and Pöhlchen introduce the reader to sleep spindles, brain oscillations that occur during nREM sleep that are thought to function in the stabilization of memories.
Schönauer, Monika, Pöhlchen, Dorothee
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eLife, 2017 Following learning, increased coupling between spindle oscillations in the medial prefrontal cortex (mPFC) and ripple oscillations in the hippocampus is thought to underlie memory consolidation.
Frances Xia +5 more
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Coupling between motor cortex and striatum increases during sleep over long-term skill learning
eLife, 2021 The strength of cortical connectivity to the striatum influences the balance between behavioral variability and stability. Learning to consistently produce a skilled action requires plasticity in corticostriatal connectivity associated with repeated ...
Stefan M Lemke +5 more
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Telocytes in neuromuscular spindles [PDF]
Journal of Cellular and Molecular Medicine, 2013 AbstractA new cell type named telocyte (TC) has recently been identified in various stromal tissues, including skeletal muscle interstitium. The aim of this study was to investigate by means of light (conventional and immunohistochemical procedures) and electron microscopy the presence of TCs in adult human neuromuscular spindles (NMSs) and lay the ...
Díaz-Flores Varela, Lucio +4 more
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Loss of PDK1 Induces Meiotic Defects in Oocytes From Diabetic Mice
Frontiers in Cell and Developmental Biology, 2021 Maternal diabetes has been shown to impair oocyte quality; however, the underlying mechanisms remain unclear. Here, using a streptozotocin (STZ)-induced diabetic mouse model, we first detected and reduced expression of pyruvate dehydrogenase kinase 1 ...
Juan Ge +8 more
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