Results 11 to 20 of about 210,409 (218)

Boundary-Dependent Sleep-Wake Dysregulation in Idiopathic Hypersomnia. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Mombelli S, Lacourse K, Blais H, Deshaies-Rugama AS, Thompson C, Desautels A, Montplaisir J, Nigam M, Moderie C, Khajehpiri B, Duclos C, Lina JM, Carrier J, Gosselin N.   +13 more
europepmc   +2 more sources

Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation

eLife, 2017
Following learning, increased coupling between spindle oscillations in the medial prefrontal cortex (mPFC) and ripple oscillations in the hippocampus is thought to underlie memory consolidation.
Frances Xia, Blake A Richards, Matthew M Tran, Sheena A Josselyn, Kaori Takehara-Nishiuchi, Paul W Frankland   +5 more
doaj   +1 more source

Retroperitoneal spindle cell variant of embryonal rhabdomyosarcoma in a child

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2019
Spindle cell rhabdomyosarcoma (RMS) is a rare variant of embryonal RMS that has a predilection for young males and most commonly involves the paratesticular region followed by the head and neck.
Aditya Pratap Singh, Arun Kumar Gupta, Arpita Jindal, Kalpana Mangal   +3 more
doaj   +1 more source

Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit

Cells, 2020
The microtubule-associated protein TPX2 is a key mitotic regulator that contributes through distinct pathways to spindle assembly. A well-characterised function of TPX2 is the activation, stabilisation and spindle localisation of the Aurora-A kinase ...
Francesco D. Naso, Valentina Sterbini, Elena Crecca, Italia A. Asteriti, Alessandra D. Russo, Maria Giubettini, Enrico Cundari, Catherine Lindon, Alessandro Rosa, Giulia Guarguaglini   +9 more
doaj   +1 more source

Reduction of the influence on machining surface caused by tool non-repeatable run-out of rolling bearing spindle for machine tools (Improvement of machining surface quality with an excitation system)

Nihon Kikai Gakkai ronbunshu, 2021
In recent years, the demands for mirror finishing by cutting have increased, because the surface quality requirement in die and mold has become severer. In order to realize mirror surface finish by cutting, it is necessary to reduce the influence of tool
Yuta SHOWA, Hayato YOSHIOKA
doaj   +1 more source

Generation and diversification of recombinant monoclonal antibodies

eLife, 2021
Antibodies are indispensable tools used for a large number of applications in both foundational and translational bioscience research; however, there are drawbacks to using traditional antibodies generated in animals.
Keith F DeLuca, Jeanne E Mick, Amy H Ide, Wanessa C Lima, Lori Sherman, Kristin L Schaller, Steven M Anderson, Ning Zhao, Timothy J Stasevich, Dileep Varma, Jakob Nilsson, Jennifer G DeLuca   +11 more
doaj   +1 more source

The Development of a Monitoring System Using a Wireless and Powerless Sensing Node Deployed Inside a Spindle

Sensors, 2011
Installation of a Wireless and Powerless Sensing Node (WPSN) inside a spindle enables the direct transmission of monitoring signals through a metal case of a certain thickness instead of the traditional method of using connecting cables.
Da-Sheng Lee, Liang-Cheng Chang
doaj   +1 more source

NuMA recruits dynein activity to microtubule minus-ends at mitosis

eLife, 2017
To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to allow dynein to cluster microtubules into
Christina L Hueschen, Samuel J Kenny, Ke Xu, Sophie Dumont   +3 more
doaj   +1 more source

Practical Estimation of Machine Tool Spindle Dynamics for Maintenance Decision Making

Applied Sciences
Condition-based maintenance of a machine tool spindle unit is known to reduce the total cost of operation in a manufacturing environment. However, standard vibration monitoring thresholds, which are based only on average vibration energy levels, do not ...
Patrick Chin, Jose M. DePavia, Stephen C. Veldhuis   +2 more
doaj   +1 more source

Live cell imaging of meiosis in Arabidopsis thaliana

eLife, 2019
To follow the dynamics of meiosis in the model plant Arabidopsis, we have established a live cell imaging setup to observe male meiocytes. Our method is based on the concomitant visualization of microtubules (MTs) and a meiotic cohesin subunit that ...
Maria A Prusicki, Emma M Keizer, Rik P van Rosmalen, Shinichiro Komaki, Felix Seifert, Katja Müller, Erik Wijnker, Christian Fleck, Arp Schnittger   +8 more
doaj   +1 more source