Results 21 to 30 of about 210,409 (218)
Cells, 2021 Tubulin post-translational modifications regulate microtubule properties and functions. Mitotic spindle microtubules are highly modified. While tubulin detyrosination promotes proper mitotic progression by recruiting specific microtubule-associated ...
Sylvia Fenosoa Rasamizafy +5 more
doaj +1 more source
PREDICTION THE EVOLUTION OF TEMPERATURE AND VIBRATIONS ON SPINDLE USING ARTIFICIAL NEURAL NETWORKS AND FUZZY LOGIC [PDF]
Annals: Series on engineering sciences (Academy of Romanian Scientists), 2016 Simulation spindle behavior in terms of temperature and vibration at higher speeds is more economical and more secure (avoid undesirable mechanical events) than testing practice.
Daniel Petru GHENCEA +2 more
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BMC Genetics, 2011 Background Metaphase cells have short spindles for efficient bi-orientation of chromosomes. The cohesin proteins hold sister chromatids together, creating Sister Chromatid Cohesion (SCC) that helps in the maintenance of short spindle lengths in metaphase.
Sanyal Kaustuv +4 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Non-REM Sleep Characteristics Predict Early Cognitive Impairment in an Aging Population
Frontiers in Neurology, 2019 Objective: Recent research suggests that sleep disorders or changes in sleep stages or EEG waveform precede over time the onset of the clinical signs of pathological cognitive impairment (e.g., Alzheimer's disease).
Jacques Taillard +18 more
doaj +1 more source
eLife, 2020 The essential functions required for mitotic spindle assembly and chromosome biorientation and segregation are not fully understood, despite extensive study.
Christopher Edelmaier +7 more
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Open Biology, 2023 In somatic cells, mitotic transcription of major satellite non-coding RNAs is tightly regulated and essential for heterochromatin formation and the maintenance of genome integrity.
Claudia Baumann +3 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Study on the 2D Equivalent Simulation Model of Bearing and Spindle for Precision Machine Tools
Machines, 2023 Precision spindle and bearings are the key components in precision machine tools. These structures greatly affect the machining accuracy and service life of the machine tools.
Shijun Xiu +4 more
doaj +1 more source