Results 21 to 30 of about 251,396 (269)

Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly [PDF]

, 2009
Mitotic spindle formation and chromosome segregation depend critically on kinetochore-microtubule (KT-MT) interactions. A new protein, termed Spindly in Drosophila and SPDL-1 in C.
Erich A. Nigg, Chan, Ying Wai, Ying, Wai Chan, Andreas Uldschmid, Uldschmid, Andreas, Schmitz, Michael H.A., Schmitz, Michael H. A., Fava, Luca L., Gerlich, Daniel W., Michael H.A. Schmitz, Ying Wai Chan, Luca L. Fava, Anna Santamaria, Nigg, Erich A., Santamaria, Anna, Daniel W. Gerlich   +15 more
core   +1 more source

Retroperitoneal spindle cell variant of embryonal rhabdomyosarcoma in a child

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2019
Spindle cell rhabdomyosarcoma (RMS) is a rare variant of embryonal RMS that has a predilection for young males and most commonly involves the paratesticular region followed by the head and neck.
Aditya Pratap Singh, Arun Kumar Gupta, Arpita Jindal, Kalpana Mangal   +3 more
doaj   +1 more source

Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit

Cells, 2020
The microtubule-associated protein TPX2 is a key mitotic regulator that contributes through distinct pathways to spindle assembly. A well-characterised function of TPX2 is the activation, stabilisation and spindle localisation of the Aurora-A kinase ...
Francesco D. Naso, Valentina Sterbini, Elena Crecca, Italia A. Asteriti, Alessandra D. Russo, Maria Giubettini, Enrico Cundari, Catherine Lindon, Alessandro Rosa, Giulia Guarguaglini   +9 more
doaj   +1 more source

Generation and diversification of recombinant monoclonal antibodies

eLife, 2021
Antibodies are indispensable tools used for a large number of applications in both foundational and translational bioscience research; however, there are drawbacks to using traditional antibodies generated in animals.
Keith F DeLuca, Jeanne E Mick, Amy H Ide, Wanessa C Lima, Lori Sherman, Kristin L Schaller, Steven M Anderson, Ning Zhao, Timothy J Stasevich, Dileep Varma, Jakob Nilsson, Jennifer G DeLuca   +11 more
doaj   +1 more source

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]

, 2009
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye, Benavente, Sandra Blanco, Elisabete Nascimento, Kurowski, Agata, Nascimento, Elisabete, Hussain, Shobbir, Ilaria Dragoni, Dragoni, Ilaria, Gillich, Astrid, Shobbir Hussain, Sandra Blanco Benavente, Astrid Gillich, Frye, Michaela, Peter Humphreys, Humphreys, Peter, Agata Kurowski   +15 more
core   +1 more source

The Development of a Monitoring System Using a Wireless and Powerless Sensing Node Deployed Inside a Spindle

Sensors, 2011
Installation of a Wireless and Powerless Sensing Node (WPSN) inside a spindle enables the direct transmission of monitoring signals through a metal case of a certain thickness instead of the traditional method of using connecting cables.
Da-Sheng Lee, Liang-Cheng Chang
doaj   +1 more source

Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis [PDF]

, 1998
The spindle checkpoint ensures proper chromosome segregation by delaying anaphase until all chromosomes are correctly attached to the mitotic spindle.
Javerzat, Jean-Paul, Javerzat, J P, Bernard, P, Hardwick, K.G., Hardwick, Kevin, Bernard, Pascal, Pascal Bernard, Jean-Paul Javerzat, Kevin Hardwick   +8 more
core   +1 more source

Mitotic Acetylation of Microtubules Promotes Centrosomal PLK1 Recruitment and Is Required to Maintain Bipolar Spindle Homeostasis

Cells, 2021
Tubulin post-translational modifications regulate microtubule properties and functions. Mitotic spindle microtubules are highly modified. While tubulin detyrosination promotes proper mitotic progression by recruiting specific microtubule-associated ...
Sylvia Fenosoa Rasamizafy, Claude Delsert, Gabriel Rabeharivelo, Julien Cau, Nathalie Morin, Juliette van Dijk   +5 more
doaj   +1 more source

NuMA recruits dynein activity to microtubule minus-ends at mitosis

eLife, 2017
To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to allow dynein to cluster microtubules into
Christina L Hueschen, Samuel J Kenny, Ke Xu, Sophie Dumont   +3 more
doaj   +1 more source

Borealin : a novel chromosomal passenger required for stability of the bipolar mitotic spindle [PDF]

, 2004
The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex.
Erich A. Nigg, Ana Carvalho, Dietlind L. Gerloff, Reto Gassmann, Sandrine Ruchaud, Nigg, E. A., Henzing, Alexander J., Nigg, Erich A., Hudson, D. E., Damien F. Hudson, Reiko Honda, Honda, Reiko, Gassmann, Reto, Gassmann, R., Ruchaud, Sandrine, Earnshaw, William C., Hudson, Damien F., Carvalho, Ana, Ruchaud, S., Honda, R., Gerloff, D. L., Earnshaw, W. C., Alexander J. Henzing, William C. Earnshaw, Henzing, A. J., Carvalho, A., Gerloff, Dietlind L.   +26 more
core   +1 more source