The Nuclear Mitotic Apparatus (NuMA) Protein: A Key Player for Nuclear Formation, Spindle Assembly, and Spindle Positioning [PDF]
Frontiers in Cell and Developmental Biology, 2021 The nuclear mitotic apparatus (NuMA) protein is well conserved in vertebrates, and dynamically changes its subcellular localization from the interphase nucleus to the mitotic/meiotic spindle poles and the mitotic cell cortex.
Tomomi Kiyomitsu, Susan Boerner
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Application of collagen triple helix repeat containing-1 and mitotic spindle apparatus antibody in small cell lung cancer diagnosis. [PDF]
J Clin Lab Anal, 2022 The clinical significance of serum collagen triple helix repeat protein‐1 (CTHRC1) and mitotic spindle apparatus antibody (MSA) in the diagnosis of small cell lung cancer (SCLC).
Liu Y +7 more
europepmc +3 more sources
Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for proper chromosome segregation.
Mohammad Zeeshan +5 more
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Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations. [PDF]
Medicine (Baltimore), 2018 Antinuclear antibodies (ANA) are key biomarkers in the evaluation of rheumatic diseases. The prevalence and clinical significance of uncommon or rare patterns, particularly those directed at the mitotic spindle apparatus (MSA), are not well understood ...
Betancur JF +7 more
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Mitotic Spindle Apparatus Abnormalities in Chronic Obstructive Pulmonary Disease Cells: A Potential Pathway to Lung Cancer. [PDF]
Cancer Prev Res (Phila), 2020 Chronic obstructive pulmonary disease (COPD) is a long-term lung disease characterized by irreversible lung damage resulting in airflow limitation, abnormal permanent air-space enlargement, and emphysema. Cigarette smoking is the major cause of COPD with
Thaiparambil J +4 more
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INTERMICROTUBULE BRIDGES IN MITOTIC SPINDLE APPARATUS [PDF]
The Journal of Cell Biology, 1970 Fine interconnections or "cross-bridges" have been observed between cytoplasmic microtubules in many different organisms (1, 3, 7, 9, 10, 12, 13) . Recently, similar bridges have been noted between the microtubules of the spindle apparatus in dividing ...
Peter K. Hepler +2 more
semanticscholar +4 more sources
Pan-cancer analysis combined with experiments explores the oncogenic role of spindle apparatus coiled-coil protein 1 (SPDL1) [PDF]
Cancer Cell International, 2022 Background The function of spindle apparatus coiled-coil protein 1 (SPDL1) as a cancer-promoting gene has been reported in a number of studies. However, the pan-cancer analysis of SPDL1 is still lacking.
Peng Song +7 more
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Phase transition of spindle-associated protein regulate spindle apparatus assembly. [PDF]
Cell, 2015 Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components.
Jiang H +6 more
europepmc +5 more sources
The centrosome and mitotic spindle apparatus in cancer and senescence [PDF]
Cell Cycle, 2010 Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in particular of centrosomal TACC (transforming acidic coiled coil) proteins in tumorigenesis and cellular ...
Stephan Schmidt +13 more
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Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease [PDF]
Biochemistry and Cell Biology, 2015 Emerging data implicates ubiquitination, a post-translational modification, in regulating essential cellular events, one of them being mitosis. In this review we discuss how various E3 ligases modulate the cortical proteins such as dynein, LGN, NuMa, Gα, along with polymerization, stability, and integrity of spindles.
Devika Srivastava, Oishee Chakrabarti
semanticscholar +5 more sources