Results 1 to 10 of about 24,599 (226)

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution [PDF]

Advanced Science
Lipid droplets (LDs) are central to cellular energy homeostasis and lipid metabolism. While LD‐associated proteins are known to regulate LD dynamics and function, their roles in LD transport and their broader cellular significance remain poorly ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
doaj   +3 more sources

Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for proper chromosome segregation.
Mohammad Zeeshan, Declan Brady, Rebecca R. Stanway, Carolyn A. Moores, Anthony A. Holder, Rita Tewari   +5 more
doaj   +2 more sources

Phase transition of spindle-associated protein regulate spindle apparatus assembly. [PDF]

Cell, 2015
Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components.
Jiang H, Wang S, Huang Y, He X, Cui H, Zhu X, Zheng Y.   +6 more
europepmc   +4 more sources

The Nuclear Mitotic Apparatus (NuMA) Protein: A Key Player for Nuclear Formation, Spindle Assembly, and Spindle Positioning [PDF]

Frontiers in Cell and Developmental Biology, 2021
The nuclear mitotic apparatus (NuMA) protein is well conserved in vertebrates, and dynamically changes its subcellular localization from the interphase nucleus to the mitotic/meiotic spindle poles and the mitotic cell cortex.
Tomomi Kiyomitsu, Susan Boerner
doaj   +3 more sources

Intermediate Filament Protein BFSP2 Controls Spindle Formation via HSC70‐Mediated Stabilization of CLTC During Oocyte meiosis [PDF]

Advanced Science
As a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis.
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
doaj   +2 more sources

Anti-Mitotic Spindle Apparatus Antoantibodies: Prevalence and Disease Association in Chinese Population. [PDF]

J Clin Lab Anal, 2016
BackgroundMitotic spindle apparatus (MSA) antibodies are rare findings with undefined clinical significance in clinical research. We aimed at investigating the prevalence and clinical significance of anti‐MSA antibodies in Chinese population.MethodsBetween 2008 and 2013, a total of 180,180 patients were studied for the presence of anti‐MSA antibodies ...
Xi Q, Wu Y, Li L, Cai B, Zhang J, Yang B, Wang L.   +6 more
europepmc   +4 more sources

A case of oculomotor nerve palsy associated with antimitotic spindle apparatus

Clinical Ophthalmology, 2011
Jong Jin Jung, Ungsoo Samuel KimDepartment of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, KoreaAbstract: In this case report, we describe a case of isolated oculomotor nerve palsy associated with antibodies ...
Kim US, Jung JJ
doaj   +7 more sources

Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations. [PDF]

Medicine (Baltimore), 2018
Antinuclear antibodies (ANA) are key biomarkers in the evaluation of rheumatic diseases. The prevalence and clinical significance of uncommon or rare patterns, particularly those directed at the mitotic spindle apparatus (MSA), are not well understood. We aimed to investigate the prevalence and clinical significance of anti-MSA patterns in a Colombian ...
Betancur JF, Londoño A, Estrada VE, Puerta SL, Osorno SM, Loaiza A, Carmona JA, Gómez-Puerta JA.   +7 more
europepmc   +3 more sources

Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length [PDF]

Advanced Science
The cytoskeleton is composed of microtubules, microfilaments, and intermediate filaments in cells. While the functions of microtubules and microfilaments have been well elucidated, the roles of intermediate filaments and associated proteins remain ...
Yu Li, Hanwen Zhang, Wenjun Zeng, Yilong Miao, Shaochen Sun, Yu Zhang, Bo Xiong   +6 more
doaj   +2 more sources

Rare Antinuclear Antibody Patterns: Relevance in Routine Laboratory Reporting [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Uncommon patterns on Human Epithelial 2 (Hep 2) substrate during Antinuclear Antibody (ANA) screening by Indirect Immunofluorescence (IIF) microscopy are not routinely reported by many laboratories since their clinical relevance is not well
Vidya Bhakta
doaj   +1 more source