Results 221 to 230 of about 36,497 (260)
Some of the next articles are maybe not open access.
Related searches:
Related searches:
The spindle assembly checkpoint
Current Opinion in Cell Biology, 1996The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to humans. Checkpoint components reside on kinetochores of chromosomes and show changes in phosphorylation and localization as cells proceed through mitosis.
A D, Rudner, A W, Murray
openaire +2 more sources
The Spindle Assembly and Spindle Position Checkpoints
Annual Review of Genetics, 2003▪ Abstract  The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by the spindle assembly checkpoint, and at least in yeast cells, penetration of one spindle pole into the bud is monitored by the spindle position checkpoint.
Daniel J, Lew, Daniel J, Burke
openaire +2 more sources
Spindle-Assembly Checkpoint and Gastrointestinal Cancer
New England Journal of Medicine, 2011To the Editor: Rio Frio et al. (Dec. 30 issue)1 report on a germline homozygous mutation in the spindle-assembly checkpoint gene BUB1B in a patient with a nonclassic form of the mosaic variegated aneuploidy syndrome, resulting in reduced expression, increased levels of constitutive aneuploidy, and multiple gastrointestinal neoplasms starting at 34 ...
de Voer, R.M. +3 more
openaire +2 more sources
Slipping past the spindle assembly checkpoint
Nature Cell Biology, 2013Error-free genome segregation depends on the spindle assembly checkpoint (SAC), a signalling network that delays anaphase onset until chromosomes have established proper spindle attachments. Three reports now quantitatively examine the sensitivity and robustness of the SAC response.
Radhika, Subramanian, Tarun M, Kapoor
openaire +2 more sources
Principles and dynamics of spindle assembly checkpoint signalling
Nature Reviews Molecular Cell Biology, 2023The transmission of a complete set of chromosomes to daughter cells during cell division is vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) ensures correct segregation by informing the cell cycle machinery of potential errors in the interactions of chromosomes with spindle microtubules prior to anaphase.
Andrew D. McAinsh, Geert J. P. L. Kops
openaire +4 more sources
The spindle assembly checkpoint in budding yeast
1997Publisher Summary This chapter discusses the spindle assembly checkpoint in budding yeast. As cells proceed through cycles of growth and division they are often challenged by environmental insult and injury as well as spontaneous errors in cellular processes. The response to cell damage requires that cells sense the damage, arrest the cell cycle, and
A F, Straight, A W, Murray
openaire +2 more sources
Sister chromatid tension and the spindle assembly checkpoint
Current Opinion in Cell Biology, 2009The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response ...
Nezi, Luigi, Musacchio, Andrea
openaire +3 more sources
The spindle-assembly checkpoint in space and time
Nature Reviews Molecular Cell Biology, 2007In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint
Musacchio, Andrea, Salmon, Edward D.
openaire +3 more sources
Determinants of robustness in spindle assembly checkpoint signalling
Nature Cell Biology, 2013The spindle assembly checkpoint is a conserved signalling pathway that protects genome integrity. Given its central importance, this checkpoint should withstand stochastic fluctuations and environmental perturbations, but the extent of and mechanisms underlying its robustness remain unknown.
Stephanie Heinrich +9 more
openaire +3 more sources