Results 131 to 140 of about 4,116 (226)

PD‐L1, PD‐1, and CTLA‐4 mRNA In Situ Expression by Canine Oral Melanoma Cells and Immune Cells of the Tumour Microenvironment

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Canine oral melanoma (OM) exhibits poor prognosis and limited treatment options. The success of immune checkpoint inhibitors (ICIs) in human melanoma has driven interest in similar therapeutic approaches in the dog, although the immunosuppressive mechanisms adopted by canine OM remain unclear. This study aimed to evaluate the expression of the
Greta Foiani, Erica Melchiotti, Katia Capello, Ilaria Porcellato, Chiara Brachelente, Selina Iussich, Davide Giacobino, Emanuela Morello, Marina Martano, Paolo Buracco, Marta Vascellari   +10 more
wiley   +1 more source

TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint

Cell Reports, 2016
Summary: Biochemical studies have indicated that p31comet and TRIP13 are critical for inactivating MAD2. To address unequivocally whether p31comet and TRIP13 are required for mitotic exit at the cellular level, their genes were ablated either ...
Hoi Tang Ma, Randy Yat Choi Poon
doaj  

MAD3 Encodes a Novel Component of the Spindle Checkpoint Which Interacts with Bub3p, Cdc20p, and Mad2p [PDF]

, 2000
Kevin Hardwick, Raymond C. Johnston, Dana L. Smith, Andrew W. Murray   +3 more
openalex   +1 more source

CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract CEP162, a 162‐kDa centrosome protein, is a crucial centrosomal adapter, mediating cell differentiation and polarization. CEP162 maintains mitosis by dynamically stabilizing microtubules. CEP162 promotes the transition zone (TZ) assembly in the basal body through interaction with CEP131, CEP290, and axoneme microtubules as well as the distal ...
Jun Yin, Jialian Bai, Xiaochong He, Wenjuan He, Hongming Miao, Mengjie Zhang, Zhongying Yu, Bing Ni   +7 more
wiley   +1 more source

Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

Nature Communications, 2017
The spindle assembly checkpoint ensures correct chromosome segregation and relies on kinetochore localization of the Bub1 and Mad1/Mad2 checkpoint proteins.
Gang Zhang, Thomas Kruse, Blanca López-Méndez, Kathrine Beck Sylvestersen, Dimitriya H. Garvanska, Simone Schopper, Michael Lund Nielsen, Jakob Nilsson   +7 more
doaj   +1 more source

Association Between Spindle Assembly Checkpoint Gene Expression and Maternal Age in Human Oocytes [PDF]

, 2000
Nury Steuerwald, Dagan Wells, S. Munné, T. Escudero, Jacques Cohen, Christine Brenner   +5 more
openalex   +1 more source

Exploration of histone protein γ‐H2AX as a prognostic factor in soft tissue sarcomas and its association with biological behavior, immune cell environment and survival in leiomyosarcoma

International Journal of Cancer, Volume 156, Issue 11, Page 2237-2250, 1 June 2025.
What's new? The remarkably poor prognosis of metastasized soft tissue sarcoma (STS) has motivated a search for novel biomarkers and therapeutic approaches. A promising candidate biomarker is H2A histone family member X (H2AX), a key player in DNA damage detection and repair pathways.
Adrian Georg Simon, Su Ir Lyu, Anne Maria Schultheis, David Stahl, Nora Wuerdemann, Sebastian Walter, Lena Hieggelke, Reinhard Buettner, Christiane Josephine Bruns, Peer Eysel, Lars Mortimer Schiffmann, Karl Knipper, Peter Mallmann, Alexander Quaas, Roland Ullrich   +14 more
wiley   +1 more source

Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

eLife
The spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing progression from metaphase to anaphase until all chromosomes are correctly attached to the mitotic spindle.
KC Farrell, Jennifer T Wang, Tim Stearns
doaj   +1 more source

Network‐Based Integrative Analysis to Identify Key Genes and Corresponding Reporter Biomolecules for Triple‐Negative Breast Cancer

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background The malignant neoplasm of the TNBC is the leading cause of death among Indian women. Recent studies identified the global burden of TNBC affecting approximately more than 40 percent of all BC cases in women worldwide. The absence of expression of receptors such as ER, PR, and HER2 characterizes TNBC.
Pooja Singh, Rupesh Chaturvedi, Pallavi Somvanshi   +2 more
wiley   +1 more source

Elevated KIF2C Expression Drives Osteosarcoma Progression by Modulating the Wnt/β‐Catenin Signaling Pathway and Contributing to an Immunosuppressive Tumor Microenvironment

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Although kinesin family member 2C (KIF2C) is implicated in various cancers, its role in osteosarcoma (OS) and the associated inflammatory microenvironment remains unclear. Methods Publicly available datasets were analyzed to determine KIF2C expression, diagnostic value, and prognostic relevance in OS. In vitro (proliferation, colony
Ya‐Yun Liu, Wu Sun, Lin Liu, Jin‐Hui Cheng, Jing‐Tang Li, Zu‐Tai Huang, Min Ouyang   +6 more
wiley   +1 more source