USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy [PDF]
Cell Death and Disease, 2023 The spindle assembly checkpoint (SAC) is an essential mechanism that ensures the accurate chromosome segregation during mitosis, thus preventing genomic instability.
Diana Campos-Iglesias +7 more
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The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation. [PDF]
Nat Commun, 2016 The spindle checkpoint senses unattached kinetochores and inhibits the Cdc20-bound anaphase-promoting complex or cyclosome (APC/C), to delay anaphase, thereby preventing aneuploidy.
Jia L, Li B, Yu H.
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A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition [PDF]
Journal of Cell Biology, 2013 The loss of the spindle checkpoint protein Bub3 is sufficient to induce aneuploidy and drive tumorigenesis when apoptosis is compromised.
Sara Morais da Silva +2 more
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CHMP4C: A novel regulator of the mitotic spindle checkpoint [PDF]
Molecular & Cellular Oncology, 2018 The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for transport
Eleni Petsalaki, George Zachos
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Phosphorylation of MAD2 at Ser195 Promotes Spindle Checkpoint Defects and Sensitizes Cancer Cells to Radiotherapy in ATM Deficient Cells. [PDF]
Front Cell Dev Biol, 2022 Wang Y +8 more
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The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling. [PDF]
Front Oncol, 2015 Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player in chromosome segregation. As part of a macromolecular complex known as the chromosome passenger complex, Aurora B concentrates early during mitosis in the ...
Krenn V, Musacchio A.
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TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. [PDF]
J Cell Biol, 2015 The ability of the conserved ATPase TRIP13PCH-2 to disassemble a Mad2-containing complex is critical to promote the spindle checkpoint response by contributing to the robust localization of Mad2 to unattached kinetochores.
Nelson CR, Hwang T, Chen PH, Bhalla N.
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Molecular basis of APC/C regulation by the spindle assembly checkpoint
Nature, 2016 In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter cell inherits an identical set of chromosomes. The SAC coordinates the correct attachment of sister chromatid kinetochores to the mitotic spindle with ...
Claudio Alfieri, Ziguo Zhang, Jing Yang
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A minimal deterministic model reveals integration of spindle assembly and position checkpoints in mitosis [PDF]
Scientific ReportsThe spindle assembly checkpoint (SAC) and spindle position checkpoint (SPOC) are essential surveillance systems that ensure accurate chromosome segregation and proper spindle orientation during mitosis.
Bashar Ibrahim
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