Results 21 to 30 of about 4,116 (226)
Bub1 kinase in the regulation of mitosis
Animal Cells and Systems, 2021 Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment of ...
Taekyung Kim, Anton Gartner
doaj +1 more source
Molecular and cellular paradigms of multidrug resistance in cancer
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya +6 more
wiley +1 more source
Alcohol extracts of Chinese bayberry branch induce S‐phase arrest and apoptosis in HepG2 cells
Food Science &Nutrition, Volume 11, Issue 1, Page 493-503, January 2023., 2023 The alcohol extracts of Chinese bayberry Myrica rubra branches (MRBE) effectively inhibited the proliferation of HepG2 cells by inducing cell cycle arrest in S phase and promoting apoptosis, with this arrest potentially mediated by the activation of p21–Cyclin–CDK (cyclin‐dependent kinase) complex signaling pathways.
Yuanyuan Zheng +8 more
wiley +1 more source
Frontiers in Genetics, 2013 As a member of the Open Biomedical Ontologies (OBO) foundry, the Protein Ontology (PRO) provides an ontological representation of protein forms and complexes and their relationships.
Karen E Ross +5 more
doaj +1 more source
Kinase Signaling in the Spindle Checkpoint [PDF]
Journal of Biological Chemistry, 2009 The spindle checkpoint is a cell cycle surveillance system that ensures the fidelity of chromosome segregation. In mitosis, it elicits the "wait anaphase" signal to inhibit the anaphase-promoting complex or cyclosome until all chromosomes achieve bipolar microtubule attachment and align at the metaphase plate. Because a single kinetochore unattached to
Hongtao Yu, Jungseog Kang
openaire +2 more sources
Genes, Chromosomes and Cancer, Volume 62, Issue 2, Page 93-100, February 2023., 2023 Abstract Chromosomal instability is a common feature in malignant tumors. Previous studies have indicated that inactivation of the classical tumor suppressor genes RB1, CDKN2A, and TP53 may contribute to chromosomal aberrations in cancer by disrupting different aspects of the cell cycle and DNA damage checkpoint machinery.
Natalie Andersson +6 more
wiley +1 more source
Cell Division, 2008 During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromosome pairs ...
Maia André F +2 more
doaj +1 more source
Toward a systems-level view of mitotic checkpoints [PDF]
Prog Biophys Mol Biol. 2015 Mar;117(2-3):217-24, 2016 Reproduction and natural selection are the key elements of life. In order to reproduce, the genetic material must be doubled, separated and placed into two new daughter cells, each containing a complete set of chromosomes and organelles. In mitosis, transition from one process to the next is guided by intricate surveillance mechanisms, known as the ...
arxiv +1 more source
Modeling Dual Pathways for the Metazoan Spindle Assembly Checkpoint [PDF]
Proc. Natl. Acad. Sci. 103 16758-16763 (2006), 2006 Using computational modelling, we investigate mechanisms of signal transduction focusing on the spindle assembly checkpoint where a single unattached kinetochore is able to signal to prevent cell cycle progression. This inhibitory signal switches off rapidly once spindle microtubules have attached to all kinetochores.
arxiv +1 more source
Chromosome cohesion and the spindle checkpoint [PDF]
Cell Cycle, 2009 Accurate chromosome segregation constitutes the basis of inheritance. Mistakes in chromosome segregation during mitosis lead to aneuploidy, a common feature of tumors. The accuracy of chromosome segregation is governed by a complex network of processes which ensure that each daughter cell receives the correct number of chromosomes.
Duncan J. Clarke +1 more
openaire +3 more sources