Results 21 to 30 of about 303,580 (303)

Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

eLife
The spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing progression from metaphase to anaphase until all chromosomes are correctly attached to the mitotic spindle.
KC Farrell, Jennifer T Wang, Tim Stearns
doaj   +2 more sources

TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint

Cell Reports, 2016
Summary: Biochemical studies have indicated that p31comet and TRIP13 are critical for inactivating MAD2. To address unequivocally whether p31comet and TRIP13 are required for mitotic exit at the cellular level, their genes were ablated either ...
Hoi Tang Ma, Randy Yat Choi Poon
doaj   +2 more sources

The spindle checkpoint and chromosome segregation in meiosis. [PDF]

FEBS J, 2015
Gorbsky GJ.
europepmc   +2 more sources

Structure of an intermediate conformer of the spindle checkpoint protein Mad2. [PDF]

Proc Natl Acad Sci U S A, 2015
Hara M, Özkan E, Sun H, Yu H, Luo X.
europepmc   +2 more sources

Cryptococcus neoformans employs both PP1 and PP2A phosphatases to silence the spindle checkpoint

Suresh AP, Cheng H, Davies T, Clark I, Spanos C, Hardwick KG.   +5 more
europepmc   +2 more sources

Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2021
The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault, Julie M Ghizzoni, Cassandra M Leech, Anne R Diers, Stephane Gesta, Vivek K Vishnudas, Niven R Narain, Rangaprasad Sarangarajan, Jennifer A Benanti   +8 more
doaj   +1 more source

The spindle checkpoint [PDF]

Journal of Cell Science, 2006
Every mitosis, replicated chromosomes must be accurately segregated into each daughter cell. Pairs of sister chromatids attach to the bipolar mitotic spindle during prometaphase, they are aligned at metaphase, then sisters separate and are pulled to opposite poles during anaphase.
Karen M, May, Kevin G, Hardwick
openaire   +2 more sources

PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression

Scientific Reports, 2021
Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segregation during mitosis to prevent chromosomal ...
Emmanuel K. Teye, Shasha Lu, Fangyuan Chen, Wenrui Yang, Thomas Abraham, Douglas B. Stairs, Hong-Gang Wang, Gregory S. Yochum, Robert A. Brodsky, Jeffrey J. Pu   +9 more
doaj   +1 more source

The spindle assembly checkpoint [PDF]

Current Biology, 2008
(Current Biology 18, R391–R395; July 22, 2008)Because of an editorial mistake, Figure 1Figure 1 of this Primer shows pairs of kinetochores (indicated by pairs of yellow dots) during telophase, instead of single kinetochores as indicated in the corrected figure that appears here. The journal regrets this error.Figure 1The SAC as a synchronization device(
Varetti, Gianluca, Musacchio, Andrea
openaire   +6 more sources

The Spindle Assembly Checkpoint [PDF]

Current Biology, 2012
During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores.
Lara-Gonzalez, Pablo, Westhorpe, Frederick G., Taylor, Stephen S.   +2 more
openaire   +2 more sources