Results 41 to 50 of about 4,116 (226)
A new view of the spindle checkpoint [PDF]
The Journal of Cell Biology, 2001 Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.
openaire +2 more sources
Cell Reports, 2015 The spindle checkpoint safeguards against chromosome loss during cell division by preventing anaphase onset until all chromosomes are attached to spindle microtubules.
Julien Espeut +5 more
doaj +1 more source
The coordination of centromere replication, spindle formation, and kinetochore-microtubule interaction in budding yeast. [PDF]
PLoS Genetics, 2008 The kinetochore is a protein complex that assembles on centromeric DNA to mediate chromosome-microtubule interaction. Most eukaryotic cells form the spindle and establish kinetochore-microtubule interaction during mitosis, but budding yeast cells finish ...
Hong Liu +3 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5887-5900, December 2022., 2022 Abstract Adenosine‐3′, 5′‐cyclic monophosphate (cAMP) produced by adenylate cyclases (ADCYs) is an established key regulator of cell homoeostasis. However, its role in cell cycle control is still controversially discussed. This study focussed on the impact of soluble HCO3− ‐activated ADCY10 on cell cycle progression.
Warunya Woranush +3 more
wiley +1 more source
PLoS ONE, 2010 Microtubule-targeting drugs induce mitotic delay at pro-metaphase by preventing the spindle assembly checkpoint to be satisfied. However, especially after prolonged treatments, cells can escape this arrest in a process called mitotic slippage.
Ana Lúcia Mena +2 more
doaj +1 more source
Unveil Sleep Spindles with Concentration of Frequency and Time [PDF]
arXiv, 2023 Objective: Sleep spindles contain crucial brain dynamics information. We introduce the novel non-linear time-frequency analysis tool 'Concentration of Frequency and Time' (ConceFT) to create an interpretable automated algorithm for sleep spindle annotation in EEG data and to measure spindle instantaneous frequencies (IFs).
arxiv
Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes. [PDF]
PLoS ONE, 2007 The spindle checkpoint delays anaphase onset until all chromosomes have attached in a bi-polar manner to the mitotic spindle. Mad and Bub proteins are recruited to unattached kinetochores, and generate diffusible anaphase inhibitors.
Patricia E Rischitor +2 more
doaj +1 more source
Chk1 Is Required for Spindle Checkpoint Function [PDF]
Developmental Cell, 2007 The spindle checkpoint delays anaphase onset in cells with mitotic spindle defects. Here, we show that Chk1, a component of the DNA damage and replication checkpoints, protects vertebrate cells against spontaneous chromosome missegregation and is required to sustain anaphase delay when spindle function is disrupted by taxol, but not when microtubules ...
William C. Earnshaw +6 more
openaire +3 more sources
PIASgamma is required for faithful chromosome segregation in human cells. [PDF]
PLoS ONE, 2006 BACKGROUND:The precision of the metaphase-anaphase transition ensures stable genetic inheritance. The spindle checkpoint blocks anaphase onset until the last chromosome biorients at metaphase plate, then the bonds between sister chromatids are removed ...
Laura A Díaz-Martínez +6 more
doaj +1 more source
A Mathematical Framework for Kinetochore-Driven Activation Feedback in the Mitotic Checkpoint [PDF]
, 2017 Proliferating cells properly divide into their daughter cells through a process that is mediated by kinetochores, protein-complexes that assemble at the centromere of each sister chromatid. Each kinetochore has to establish a tight bipolar attachment to the spindle apparatus before sister-chromatid separation is initiated.
arxiv +1 more source