Results 41 to 50 of about 303,580 (303)
Cell Division, 2008 During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromosome pairs ...
Maia André F +2 more
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Oxidative Stress Overrides the Spindle Checkpoint [PDF]
Cell Cycle, 2007 Aneuploidy, an abnormal chromosome set, can ensue from failure of the spindle checkpoint, the safeguard mechanism that halts anaphase onset until mitotic spindle assembly. Inefficiency of cells to maintain the normal chromosome set across cell generations has been linked to tumorigenesis and senescence.
D'ANGIOLELLA V +2 more
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The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment
Stem Cell Reports, 2017 Summary: The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells.
Andreas Brown +9 more
doaj +1 more source
Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint. [PDF]
PLoS Genetics, 2012 The attachment of sister kinetochores by microtubules emanating from opposite spindle poles establishes chromosome bipolar attachment, which generates tension on chromosomes and is essential for sister-chromatid segregation.
Fengzhi Jin +4 more
doaj +1 more source
Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
Cell Division, 2009 The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E +3 more
doaj +1 more source
Spindle assembly checkpoint silencing and beyond [PDF]
Cell Cycle, 2016 The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in the absence of kinetochore-microtubule attachment, ensuring that cells with unattached kinetochores do not proceed into anaphase.
Michael, Bokros, Yanchang, Wang
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Some assembly required: Redefining the mitotic checkpoint
Molecular & Cellular Oncology, 2017 The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation.
John C. Meadows, Jonathan B. A. Millar
doaj +1 more source
Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint
Cell Division, 2007 During mitosis, the genome duplicated during S-phase is synchronously and accurately segregated to the two daughter cells. The spindle checkpoint prevents premature sister-chromatid separation and mitotic exit.
Yu Hongtao, Díaz-Martínez Laura A
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Kinase Signaling in the Spindle Checkpoint [PDF]
Journal of Biological Chemistry, 2009 The spindle checkpoint is a cell cycle surveillance system that ensures the fidelity of chromosome segregation. In mitosis, it elicits the "wait anaphase" signal to inhibit the anaphase-promoting complex or cyclosome until all chromosomes achieve bipolar microtubule attachment and align at the metaphase plate. Because a single kinetochore unattached to
Jungseog, Kang, Hongtao, Yu
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Orchestration of the spindle assembly checkpoint by CDK1‐cyclin B1
FEBS Letters, 2019 In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle assembly is complete once there are no longer any unattached kinetochores. Here,
D. Hayward +2 more
semanticscholar +1 more source