Results 51 to 60 of about 303,580 (303)
The coordination of centromere replication, spindle formation, and kinetochore-microtubule interaction in budding yeast. [PDF]
PLoS Genetics, 2008 The kinetochore is a protein complex that assembles on centromeric DNA to mediate chromosome-microtubule interaction. Most eukaryotic cells form the spindle and establish kinetochore-microtubule interaction during mitosis, but budding yeast cells finish ...
Hong Liu +3 more
doaj +1 more source
Nature Communications, 2019 The anaphase-promoting complex/cyclosome (APC/C) orchestrates cell cycle progression by controlling the temporal degradation of specific cell cycle regulators.
Suyang Zhang, T. Tischer, D. Barford
semanticscholar +1 more source
Chromosome cohesion and the spindle checkpoint [PDF]
Cell Cycle, 2009 Accurate chromosome segregation constitutes the basis of inheritance. Mistakes in chromosome segregation during mitosis lead to aneuploidy, a common feature of tumors. The accuracy of chromosome segregation is governed by a complex network of processes which ensure that each daughter cell receives the correct number of chromosomes.
Laura A, Díaz-Martínez +1 more
openaire +2 more sources
PLoS ONE, 2010 Microtubule-targeting drugs induce mitotic delay at pro-metaphase by preventing the spindle assembly checkpoint to be satisfied. However, especially after prolonged treatments, cells can escape this arrest in a process called mitotic slippage.
Ana Lúcia Mena +2 more
doaj +1 more source
Cell Reports, 2015 The spindle checkpoint safeguards against chromosome loss during cell division by preventing anaphase onset until all chromosomes are attached to spindle microtubules.
Julien Espeut +5 more
doaj +1 more source
Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint. [PDF]
PLoS ONE, 2016 The multi-functional molecular motor cytoplasmic dynein performs diverse essential roles during mitosis. The mechanistic importance of the dynein Light Intermediate Chain homologs, LIC1 and LIC2 is unappreciated, especially in the context of mitosis ...
Sagar P Mahale +2 more
doaj +1 more source
Spindle assembly checkpoint, aneuploidy and tumorigenesis [PDF]
Cell Cycle, 2009 Faithfully distributing chromosomes into two daughter cells in mitosis is essential for the maintenance of the integrity of the genome genome. The fidelity is achieved through a number of cellular processes among which is the spindle assembly checkpoint (SAC), an elaborate molecular pathway that monitors the attachment of microtubules to kinetochores ...
Min, Li, Pumin, Zhang
openaire +2 more sources
Expression and function analysis of mitotic checkpoint genes identifies TTK as a potential therapeutic target for human hepatocellular carcinoma. [PDF]
PLoS ONE, 2014 The mitotic spindle checkpoint (SAC) genes have been considered targets of anticancer therapies. Here, we sought to identify the attractive mitotic spindle checkpoint genes appropriate for human hepatocellular carcinoma (HCC) therapies.
Xiao-Dong Liang +12 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes. [PDF]
PLoS ONE, 2007 The spindle checkpoint delays anaphase onset until all chromosomes have attached in a bi-polar manner to the mitotic spindle. Mad and Bub proteins are recruited to unattached kinetochores, and generate diffusible anaphase inhibitors.
Patricia E Rischitor +2 more
doaj +1 more source