Results 1 to 10 of about 39 (39)
British Journal of Clinical Pharmacology, EarlyView.Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili +6 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade +7 more
wiley +1 more source
Journal of Anatomy, EarlyView.This paper examines the life and legacy of British anatomist Sir Wilfrid Le Gros Clark through his neuroanatomical teaching collection at the University of Oxford. The authors catalogued 103 specimens and analyzed selected slides—including cases of multiple sclerosis, amyotrophic lateral sclerosis, tabes dorsalis, syringomyelia, and the pineal gland's ...
Shiva A. Nischal +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Acute itch was experimentally induced using histamine and cowage in control participants (with no neuronopathy) and in IW, a participant with a large‐fibre sensory neuronopathy resulting in the loss of Aβ afferent function below C3, at the same time as largely preserving Aδ and C‐fibre function.
Adarsh D. Makdani +3 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Peripheral nerve injury induces dynamic cortical plasticity, driven by molecular mechanisms such as BDNF and neurotransmitter systems. This review synthesizes subtype‐specific plasticity patterns: compressive injuries trigger rapid reorganization, while metabolic neuropathies lead to maladaptive changes.
Cong Cheng +8 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Fiber photometry revealed Ca2+ dynamics across multiple thalamic nuclei during nociceptive stimulation. Notably, all recorded thalamic nuclei were activated by nociceptive stimulation. Moreover, medial thalamic nuclei exhibited markedly stronger Ca2+ responses than lateral nuclei, suggesting a medial‐lateral difference in thalamic responses.
Yao‐Hua Liu +10 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.To address the critical challenge of lacking objective prognostic neural markers for evaluating long‐term efficacy of spinal cord stimulation (SCS) in disorders of consciousness (DoC), this study proposed an EEG‐based dynamic functional connectivity (dFC) framework, uncovering SCS‐induced transient neural reorganization through higher‐order feature ...
Yinuo Liu +6 more
wiley +1 more source
European Journal of Pain, Volume 30, Issue 8, September 2026.ABSTRACT Background and Objectives Multiple sclerosis (MS) is a neurodegenerative disorder frequently leading to neuropathic pain. Due to the neurodegenerative nature, the diagnosis of neuropathic pain remains challenging. A grading system has been developed providing an overview of diagnostic certainty (i.e., possible, probable and definite). Since no
Rasmus C. Jungersen +4 more
wiley +1 more source
European Journal of Neurology, Volume 33, Issue 9, September 2026.Thoracic spinal cord injury is associated with significant remote degeneration of the uninjured cervical cord, even in the absence of direct cervical damage. Compared to able‐bodied controls, individuals with chronic thoracic injury showed reduced cervical cross‐sectional area and antero‐posterior/right–left diameters, along with increased eccentricity
Yann Quidé +8 more
wiley +1 more source
A guide to neuromodulation in drug‐resistant epilepsy
Epileptic Disorders, Volume 28, Issue 4, Page 953-980, August 2026.Abstract Neuromodulation is approved for the treatment of drug‐resistant epilepsy. It has been increasingly utilized over the past two decades with the approval of deep brain stimulation (DBS) and responsive neurostimulation (RNS) in addition to vagus nerve stimulation (VNS)—particularly in patients who are not deemed to be good resective surgical ...
Prachi Parikh +10 more
wiley +1 more source