Results 1 to 10 of about 6,769 (246)

Spiperone Stimulates Regeneration in Pulmonary Endothelium Damaged by Cigarette Smoke and Lipopolysaccharide [PDF]

International Journal of COPD, 2021
Evgenii Skurikhin,1 Olga Pershina,1 Mariia Zhukova,1 Darius Widera,2 Edgar Pan,1 Angelina Pakhomova,1 Vyacheslav Krupin,1 Natalia Ermakova,1 Victoria Skurikhina,3 Lubov Sandrikina,1 Sergey Morozov,4 Aslan Kubatiev,4 Alexander Dygai1,4 1Laboratory of ...
Skurikhin E, Pershina O, Zhukova M, Widera D, Pan E, Pakhomova A, Krupin V, Ermakova N, Skurikhina V, Sandrikina L, Morozov S, Kubatiev A, Dygai A   +12 more
doaj   +8 more sources

Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone [PDF]

Nature Communications, 2020
The dopamine D2 receptor (D2R) is a GPCR and an important drug target for schizophrenia treatment. Here, the authors present the crystal structure of human D2R in complex with the antipsychotic drug spiperone, which is of interest for designing ...
Dohyun Im, Asuka Inoue, Takaaki Fujiwara, Takanori Nakane, Yasuaki Yamanaka, Tomoko Uemura, Chihiro Mori, Yuki Shiimura, Kanako Terakado Kimura, Hidetsugu Asada, Norimichi Nomura, Tomoyuki Tanaka, Ayumi Yamashita, Eriko Nango, Kensuke Tono, Francois Marie Ngako Kadji, Junken Aoki, So Iwata, Tatsuro Shimamura   +18 more
doaj   +7 more sources

Micellar Hyaluronidase and Spiperone as a Potential Treatment for Pulmonary Fibrosis. [PDF]

Int J Mol Sci, 2021
Concentration of hyaluronic acid (HA) in the lungs increases in idiopathic pulmonary fibrosis (IPF). HA is involved in the organization of fibrin, fibronectin, and collagen.
Skurikhin E, Madonov P, Pershina O, Ermakova N, Pakhomova A, Widera D, Pan E, Zhukova M, Sandrikina L, Artamonov A, Dygai A.   +10 more
europepmc   +8 more sources

Dissecting the Mechanism of Action of Spiperone-A Candidate for Drug Repurposing for Colorectal Cancer. [PDF]

Cancers (Basel), 2022
Simple Summary Despite advances in primary and adjuvant treatments, approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease.
Antona A, Varalda M, Roy K, Favero F, Mazzucco E, Zuccalà M, Leo G, Soggia G, Bettio V, Tosi M, Gaggianesi M, Riva B, Reano S, Genazzani A, Manfredi M, Stassi G, Corà D, D'Alfonso S, Capello D.   +18 more
europepmc   +4 more sources

A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization [PDF]

Scientific Reports, 2017
The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Sara Marsango, Gianluigi Caltabiano, Mireia Jiménez-Rosés, Mark J. Millan, John D. Pediani, Richard J. Ward, Graeme Milligan   +6 more
doaj   +3 more sources

The D2 antagonist spiperone mimics the effects of olfactory deprivation on mitral/tufted cell odor response patterns [PDF]

Journal of Neuroscience, 1995
Wistar rats had a single nare occluded on postnatal day 30, depriving the ipsilateral olfactory bulb of odor stimulation. The deprivation lasted for either 1–2 months (short-term) or 12 months (long-term).
Dawn N. Wilson, R. Sullivan
semanticscholar   +2 more sources

Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia. [PDF]

PLoS ONE, 2014
The putamen has a somatotopic organization of neurons identified by correspondence of firing rates with selected body part movements, as well as by complex, but organized, differential cortical projections onto putamen.
Kevin J Black, Abraham Z Snyder, Jonathan W Mink, Veeral N Tolia, Fredy J Revilla, Stephen M Moerlein, Joel S Perlmutter   +6 more
doaj   +5 more sources

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling [PDF]

Frontiers in Public Health, 2023
BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and ...
John Tyler, John Tyler, Madeline Podaras, Madeline Podaras, Brittany Richardson, Brittany Richardson, Nicole Roeder, Nicole Roeder, Nikki Hammond, John Hamilton, Kenneth Blum, Mark Gold, David A. Baron, Panayotis K. Thanos, Panayotis K. Thanos   +14 more
doaj   +2 more sources

Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors. [PDF]

PLoS ONE, 2016
Many G protein-coupled receptors have been shown to be sensitive to the presence of sodium ions (Na+). Using radioligand competition binding assays, we have examined and compared the effects of sodium ions on the binding affinities of a number of ...
Claire L Newton, Martyn D Wood, Philip G Strange   +2 more
doaj   +7 more sources

Genome-Wide Meta-Analysis of Parkinson's Disease Associated Genetic Loci and Validation of Therapeutic Targets. [PDF]

Brain Behav
This study identified genetic loci associated with Parkinson's disease through a genome‐wide meta‐analysis, screened druggable genes significantly linked to PD risk, and assessed the potential of GCLC and GFPT1 as therapeutic targets. ABSTRACT Background To identify genetic loci associated with Parkinson's disease (PD) through a genome‐wide meta ...
Yang S, Wu Q, Yang X.
europepmc   +2 more sources