Insights into the mechanism by which atropine inhibits myopia: evidence against cholinergic hyperactivity and modulation of dopamine release. [PDF]
Br J Pharmacol, 2021 Background and Purpose The ability of the muscarinic cholinergic antagonist atropine to inhibit myopia development in humans and animal models would suggest that cholinergic hyperactivity may underlie myopic growth. To test this, we investigated whether cholinergic agonists accelerate ocular growth rates in chickens.
Thomson K +4 more
europepmc +2 more sources
Aquaculture ReportsIn this study, we further investigate the hypothesis that serotonin plus spiperone (Ser+Spi) injection induces ovarian maturation and releases ovarian maturation inducing pheromones into the water, thereby stimulating neighboring untreated females ...
Isabel Quesada-Ávila +5 more
doaj +2 more sources
Light Inhibits Lens-Induced Myopia through an Intensity-Dependent Dopaminergic Mechanism [PDF]
Ophthalmology SciencePurpose: Bright light exposure has been postulated to underlie the ability of time spent outdoors to prevent the development of myopia in humans. In support of this, bright light inhibits the development of form-deprivation myopia (FDM) in all species ...
Cindy Karouta, PhD +3 more
doaj +2 more sources
Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway [PDF]
BMC Pharmacology, 2009 Wnt signaling affects fundamental development pathways by regulating cell proliferation and differentiation. Aberrant activation of Wnt/beta-catenin signaling promotes the development of several cancers and is an attractive target for chemopreventive and chemotherapeutic agents.In order to identify the novel antagonists for the Wnt/beta-catenin pathway,
Desheng Lu, Dennis A. Carson
openalex +3 more sources
Spiperone: evidence for uptake into secretory granules. [PDF]
Proceedings of the National Academy of Sciences, 1984 Spiperone, a dopamine antagonist widely used as a specific ligand for dopamine and serotonin receptors, is actively accumulated into the F4C1 strain of rat pituitary tumor cells. The accumulation of 10 nM [3H]spiperone was linear for 3 min and reached a steady state after 10 min.
P S Dannies +3 more
openalex +4 more sources
In vitro Pharmacological Profile of 3-N-(2-Fluoroethyl)Spiperone [PDF]
Journal of Cerebral Blood Flow & Metabolism, 1990 The binding affinities of spiperone and 3-N-(2-fluoroethyl)spiperone (FESP) have been compared for several rodent brain receptor sites and for inhibition of monoamine release and uptake sites. FESP and spiperone have almost identical profiles, namely a high affinity for dopamine-D2and serotonin-S2receptors, a low affinity for α1-adrenergic receptors ...
André M. Goffinet +2 more
openalex +3 more sources
Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis [PDF]
Frontiers in Molecular BiosciencesIntroductionExtensive efforts have been made to explore members of the IL-10 family as potential therapeutic strategies for various diseases; however, their biological role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains underexplored ...
Xinghong Liu +5 more
doaj +2 more sources
Decreased [18F]Spiperone Binding in Putamen in Idiopathic Focal Dystonia [PDF]
The Journal of Neuroscience, 1997 In this study we have investigated the pathophysiology of two idiopathic focal dystonias: hand cramp with excessive cocontractions of agonist and antagonist hand or forearm muscles during specific tasks, such as writing, and facial dystonia manifested by involuntary eyelid spasms (blepharospasm) and lower facial and jaw spasms (oromandibular dystonia).
Joel S. Perlmutter +6 more
openalex +4 more sources
Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer [PDF]
Cancers (Basel), 2022 Annamaria Antona +18 more
openalex +2 more sources
Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer’s disease [PDF]
Journal of NeuroinflammationBackground Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clinical benefit. Neuroinflammation is
Carla Cuní-López +9 more
doaj +2 more sources