Iheringia: Série Zoologia, 2009 O efeito estimulante da spiperona e da naloxana sob a maturação ovariana foram avaliados em fêmeas de Aegla uruguayana Schmitt, 1942 e, para isto, tais neuroreguladores foram incorporados ao alimento e administrados a uma dose de 10-8 mol/animal a cada ...
Daniela da S. Castiglioni +5 more
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Molecular cloning of a novel gene involved in serotonin receptor-mediated signal transduction in rat stomach [PDF]
, 1997 In Xenopus oocytes injected with small size mRNAs (500–700 b), obtained from rat stomach by fractionation, application of 10 μM 5-HT induced a substantial Ca2+-activated Cl− current (ICl-Ca). ICl-Ca was not elicited by 5-HT in native oocytes.
Imaizumi, Yuji +6 more
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Pharmacology of novel psychoactive substances [PDF]
, 2016 This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
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Adrenergic agonists induce heterologous sensitization of adenylate cyclase in NS20Y-D2L cells [PDF]
, 2001 Adenylate cyclase activity in NS20Y cells expressing D2L dopamine receptors was examined following chronic treatment with norepinephrine and epinephrine.
Cumbay, Medhane G +3 more
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[3H]-Spiperone Saturation Binding to Dopamine D2, D3 and D4 Receptors
Bio-Protocol, 2013 This protocol is intended for use in 96 well plates (1,200 μl wells) but it can similarly be applied to standard test tubes (Levant, 2007). D2, D3, and D4 dopamine receptors are members of the D2-like class of dopamine receptors.
Jan-Peter Wieringen, Martin Michel
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τBu₂SiF-Derivatized D₂-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging [PDF]
, 2011 The synthesis, radiolabeling and in vitro evaluation of new silicon-fluoride acceptor (SiFA) derivatized D-2-receptor ligands is reported. The SiFA-technology simplifies the introduction of fluorine-18 into target specific biomolecules for Positron ...
Bartenstein, Peter +10 more
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Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand [PDF]
, 2015 We recently demonstrated that SB269652 (1) engages one protomer of a dopamine D2 receptor (D2R) dimer in a bitopic mode to allosterically inhibit the binding of dopamine at the other protomer.
Alvarez G. L. +13 more
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Journal of Toxicology, 2017 The herbicide atrazine (ATR) has a potential toxic effect on the neuronal circuits of the brain, specifically on two major dopaminergic pathways: the nigrostriatal and mesolimbic circuits.
José Abraham Márquez-Ramos +3 more
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A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice [PDF]
, 2010 BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically
Auburger, Georg +17 more
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Cdk5 Phosphorylates Dopamine D2 Receptor and Attenuates Downstream Signaling [PDF]
The dopamine D2 receptor (DRD2) is a key receptor that mediates dopamine-associated brain functions such as mood, reward, and emotion. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase whose function has been implicated in ...
Gho, YS +10 more
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