Results 51 to 60 of about 4,814 (215)

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source

Dopamine D_2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive 4 nicotinic receptors via a cholinergic-dependent mechanism [PDF]

, 2010
Recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nAChRs) containing α4 and β2 subunits (α4β2*) functionally interact with G-protein-coupled dopamine (DA) D_2 receptors in basal ganglia.
Andrew R. Tapper, Bruce N. Cohen, Coward D. M., Franklin K. B. J., Henry A. Lester, Herwig Just, Janssen P. A., Lester H. A., Mercuri N. B., Outi Salminen, Paul D. Gardner, Paul Whiteaker, Raz A., Rubing Zhao-Shea, Salminen O., Sharon R. Grady, Sotnikova T. D., Tapper A. R., Tristan McClure-Begley   +18 more
core   +3 more sources

A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion [PDF]

, 2016
A PEG–haloperidol conjugate containing a non-biodegradable linker was synthesised. Incubation with rat plasma demonstrated excellent linker stability, and competition radioligand binding assays demonstrated retained binding to the D2-receptor.
Abbott, Almutairi, Amy Newman, Anden, Banks, Beaulieu, Benjamin J. Whalley, Bettio, Borovac, Bressen, Chiara Clementi, Chu, de Groot, Dietrichson, Duncan, Eliassi, Etrych, Felder, Felicity Heath, Francesca Greco, Fu, Gary J. Stephens, Gianfranco Pasut, Gildea, Greco, Hall, Hans, Hans, Helen M. I. Osborn, Hindmarch, Hong Lin, Howe, Iversen, Iwaki, Levin, Liechty, Lopez-Munoz, Mikhail, Missale, Mukherjee, Pal, Pardridge, Pardridge, Pardridge, Pasut, Satchi-Fainaro, Shena, Sibley, Simons, Snyder, Veronese, Wang, Williamson, Yang   +53 more
core   +1 more source

[3H]-Spiperone Competition Binding to Dopamine D2, D3 and D4 Receptors

Bio-Protocol, 2013
This protocol is intended for use in 96 well plates (1,200 μl wells) but it can similarly be applied to standard test tubes (Levant, 2007). D2, D3, and D4 dopamine receptors are members of the D2-like class of dopamine receptors.
Jan-Peter Wieringen, Martin Michel
doaj   +1 more source

The Hypoactivity Associated with the Repeated Exposure to Atrazine Is Related to Decreases in the Specific Binding to D1-DA Receptors in the Striatum of Rats

Journal of Toxicology, 2017
The herbicide atrazine (ATR) has a potential toxic effect on the neuronal circuits of the brain, specifically on two major dopaminergic pathways: the nigrostriatal and mesolimbic circuits.
José Abraham Márquez-Ramos, Isela Hernández-Plata, Mauricio Díaz-Muñoz, Verónica M. Rodríguez   +3 more
doaj   +1 more source

Evidence for the Involvement of Dopamine in Ambulation Promoted by Menthol in Mice

Journal of Pharmacological Sciences, 2003
The present study examines the mechanism that underlies the ability of menthol (ME), a major constituent of peppermint oil, to promote mouse ambulation. We initially confirmed that bupropion (BUP), a dopamine (DA) uptake inhibitor, promotes ambulation in
Toyoshi Umezu, Masatoshi Morita
doaj   +1 more source

Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT1A receptors but not 5-HT2A receptors [PDF]

, 2013
Atypical antipsychotic drugs (APDs) increase dopamine (DA) release in prefrontal cortex (PFC), an effect probably mediated by the direct or indirect activation of the 5-HT1A receptor (5-HT1AR).
Artigas, Francesc, Bortolozzi, Analía, Cortés, Roser, Díaz-Mataix, Llorenç, Gingrich, Jay A., Masana, Mercè, Scorza, María Cecilia, Toth, Miklos   +7 more
core   +2 more sources

Time outdoors and the prevention of myopia [PDF]

, 2015
Recent epidemiological evidence suggests that children who spend more time outdoors are less likely to be, or to become myopic, irrespective of how much near work they do, or whether their parents are myopic.
Ashby, Regan S., French, Amanda N., Morgan, Ian G., Rose, Kathryn A.   +3 more
core   +1 more source

Possible Involvement of Endogenous 5-HT in Aggravation of Cerulein-Induced Acute Pancreatitis in Mice

Journal of Pharmacological Sciences, 2007
The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the
Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Yoshiki Yagi, Shuichi Kanazashi, Yasunari Kashihara, Koji Takeuchi, Isamu Yamaguchi   +7 more
doaj   +1 more source

Cdk5 Phosphorylates Dopamine D2 Receptor and Attenuates Downstream Signaling [PDF]

The dopamine D2 receptor (DRD2) is a key receptor that mediates dopamine-associated brain functions such as mood, reward, and emotion. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase whose function has been implicated in ...
Gho, YS, Hwang, D, Jeong, J, Kim, DK, Kwak, Y, Lee, H, Lee, S, Lee, SA, PARK, SANG KI, Park, YU, Suh, YH   +10 more
core   +1 more source