Results 71 to 80 of about 4,814 (215)

Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo, Mathilda Bonnet, Ons Laouej, Celine Defaix, Josephine C. McGowan, Florence Butlen‐Ducuing, Denis J. David, Erwan Poupon, Laurent Tritschler, Alain M. Gardier   +9 more
wiley   +1 more source

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation [PDF]

, 2010
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior ...
Arvanites, Anthony, Haggarty, Stephen J., Jang, Sumin, Kokel, David, Lam, Kelvin, Peterson, Randall T., Prober, David A., Rihel, Jason, Rubin, Lee L., Schier, Alexander F., Zimmerman, Steven   +10 more
core   +1 more source

Synthesis of Pyrrolidin‐3‐Ones and Spiropyrrolidinones by 1,3‐Dipolar Cycloadditions of Nitrones with Allenylphosphonates

European Journal of Organic Chemistry, Volume 28, Issue 27, July 25, 2025.
This work introduces an efficient and gram‐scale microwave‐assisted (3+2) cycloaddition of nitrones with fluorinated allenylphosphonates, yielding diverse 4‐phosphinyl‐pyrrolidin‐3‐ones with exclusive 4,5‐trans diastereoselectivity in moderate to good yields.
Rayhane Hammami, Lucas Mele, Soufiane Touil, David Virieux, Jean‐François Poisson, Tahar Ayad, Benjamin Darses   +6 more
wiley   +1 more source

Pharmacological profile of novel psychoactive benzofurans [PDF]

, 2015
Benzofurans are newly used psychoactive substances, but their pharmacology is unknown. The aim of the present study was to pharmacologically characterize benzofurans in vitro.; We assessed the effects of the benzofurans 5-APB, 5-APDB, 6-APB, 6-APDB, 4 ...
Hoener, Marius C., Kopf, Simone, Liechti, Matthias E., Rickli, Anna   +3 more
core   +1 more source

Current status and features of antipsychotic prescriptions in Japanese forensic psychiatric wards based on a forensic inpatient database

Neuropsychopharmacology Reports, Volume 45, Issue 1, March 2025.
We analyzed the current status of antipsychotics for Japanese forensic inpatients with schizophrenia spectrum disorders nationwide. Olanzapine was the most commonly prescribed antipsychotic, followed by clozapine. Clozapine was associated with longer hospitalization and a higher rate of seclusion experience.
Koji Takeda, Hiroko Kashiwagi, Keisuke Takanobu, Ryotaro Kubota, Ryo Naoe, Yuji Yamada, Junko Koike, Toshiaki Kono, Yuki Kako, Naotsugu Hirabayasi   +9 more
wiley   +1 more source

Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs) [PDF]

, 2017
4-Thio-substituted phenethylamines (2C-T drugs) are potent psychedelics with poorly defined pharmacological properties. Because of their psychedelic effects, 2C-T drugs are sometimes sold as new psychoactive substances (NPSs).
Hoener, Marius C., Liechti, Matthias E., Luethi, Dino, Trachsel, Daniel   +3 more
core   +1 more source

Aromatic linker variations in novel dopamine D2 and D3 receptor ligands

Archiv der Pharmazie, Volume 357, Issue 8, August 2024.
Within the blueprint motifs of dopamine D2R/D3R ligands, the butyl (tetramethylene) linker was replaced by substituted benzyl or phenethyl linkers, maintaining high affinities at both receptor subtypes. Abstract Dopamine D2‐like receptors, especially D2 and D3 receptor subtypes, are important targets of antipsychotic agents.
Cristian Di Biase, Luisa Leitzbach, Annika Frank, Aleksandra Zivkovic, Holger Stark   +4 more
wiley   +1 more source

Decreased olfactory discrimination is associated with impulsivity in healthy volunteers [PDF]

, 2018
In clinical populations, olfactory abilities parallel executive function, implicating shared neuroanatomical substrates within the ventral prefrontal cortex.
A Bari, A Bari, A Ghanizadeh, A Hampshire, AB Fagundo, AC Swann, AJ Caswell, AK Anderson, AM Herman, Anselm B. M. Fuermaier, AS Cohen, B Atanasova, BI Turetsky, C Corcoran, C Schilling, C Winstanley, C.J. Mauro, David R. Gastfriend, DI Lubman, DP Devanand, E Guise de, EE DeVito, G Bersani, G Schoenbaum, GM Ditraglia, H Potter, H Taalman, HJ Westervelt, HTT Ngo, I Savic, J Biederman, J Martzke, J Plailly, JA Gottfried, JD Jentsch, JF Dileo, JH Patton, JL Perry, JW Dalley, K Matsuo, K Nikolaou, KN Kirby, L Clark, LJ Seidman, M Hedner, M Romanos, M Schecklmann, M Senderecka, MAM Peluso, Naresh Acharya, P Kohli, P Maurage, P Maurage, P Shear, PJ Moberg, RL Doty, S Bartholdy, S Kivity, S Rahayel, SM Manasse, SS Cho, T Bitter, T Wolfers, TM Bettison, Y Suzuki   +64 more
core   +2 more sources

Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine‐Independent and Chronic Itch

Advanced Science, Volume 11, Issue 15, April 17, 2024.
The potassium channel Slack is highly expressed in sensory neurons that sense itch. In this study, several new compounds that activate Slack are developed. It is found that the lead molecule, compound 6, effectively inhibits scratching elicited by multiple pruritogens in mice establishing Slack activation as a novel pharmacological strategy for the ...
Annika Balzulat, W. Felix Zhu, Cathrin Flauaus, Victor Hernandez‐Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko   +20 more
wiley   +1 more source

Blockade D2 dopamine receptors as a new approach to correction of violations in alveolar parenchyma and regulation of endothelial progenitor cells in pulmonary emphysema [PDF]

, 2018
On the model of emphysema of the lungs caused by an extract of cigarette smoke or elastase, it was shown that spiperone has an anti-inflammatory effect, reduces the area of emphysema, stimulates the regeneration of alveolar cells and the microvascular ...
Жукова, М. А., Крупин, В. А., Пан, Э. С.   +2 more
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