Results 71 to 80 of about 4,488 (204)

A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion [PDF]

, 2016
A PEG–haloperidol conjugate containing a non-biodegradable linker was synthesised. Incubation with rat plasma demonstrated excellent linker stability, and competition radioligand binding assays demonstrated retained binding to the D2-receptor.
Abbott, Almutairi, Amy Newman, Anden, Banks, Beaulieu, Benjamin J. Whalley, Bettio, Borovac, Bressen, Chiara Clementi, Chu, de Groot, Dietrichson, Duncan, Eliassi, Etrych, Felder, Felicity Heath, Francesca Greco, Fu, Gary J. Stephens, Gianfranco Pasut, Gildea, Greco, Hall, Hans, Hans, Helen M. I. Osborn, Hindmarch, Hong Lin, Howe, Iversen, Iwaki, Levin, Liechty, Lopez-Munoz, Mikhail, Missale, Mukherjee, Pal, Pardridge, Pardridge, Pardridge, Pasut, Satchi-Fainaro, Shena, Sibley, Simons, Snyder, Veronese, Wang, Williamson, Yang   +53 more
core   +1 more source

Evidence for the Involvement of Dopamine in Ambulation Promoted by Menthol in Mice

Journal of Pharmacological Sciences, 2003
The present study examines the mechanism that underlies the ability of menthol (ME), a major constituent of peppermint oil, to promote mouse ambulation. We initially confirmed that bupropion (BUP), a dopamine (DA) uptake inhibitor, promotes ambulation in
Toyoshi Umezu, Masatoshi Morita
doaj  

Neurochemical and Behavioral Effects of Acute and Chronic Treatment with Apomorphine in Rats [PDF]

, 1991
An article written by Bruce A.
Bardo, Michael T., Mattingly, Bruce A., Rowlett, James K.   +2 more
core   +1 more source

Possible Involvement of Endogenous 5-HT in Aggravation of Cerulein-Induced Acute Pancreatitis in Mice

Journal of Pharmacological Sciences, 2007
The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the
Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Yoshiki Yagi, Shuichi Kanazashi, Yasunari Kashihara, Koji Takeuchi, Isamu Yamaguchi   +7 more
doaj  

Studies of drug-lipid interactions [PDF]

, 2014
Positron emission tomography (PET) is increasingly being used by the pharmaceutical industry in drug development. Drugs are designed to bind to a specific target, which is usually a membrane embedded receptor or an enzyme.
Macey, Rosa
core   +1 more source

Olfactory ensheathing cell transplantation restores functional deficits in rat model of Parkinson's disease: a cotransplantation approach with fetal ventral mesencephalic cells

Neurobiology of Disease, 2004
Different strategies have been worked out to promote survival of transplanted fetal ventral mesencephalic cells (VMCs) using trophic and nontrophic support. Olfactory ensheathing cells (OECs) express high level of growth factors including NGF, bFGF, GDNF,
A.K Agrawal, S Shukla, R.K Chaturvedi, K Seth, N Srivastava, A Ahmad, P.K Seth   +6 more
doaj  

Ovarian Steroids Modulate the Release of Dopamine into Hypophysial Portal Blood and the Density of Anterior Pituitary [³H]Spiperone-Binding Sites in Ovariectomized Rats* [PDF]

, 1984
Nancy S. Pilotte, David R. Burt, Charles A. Barraclough   +2 more
openalex   +1 more source

Amphetamine pretreatment blunts dopamine-induced D2/D3-receptor occupancy by an arrestin-mediated mechanism: A PET study in internalization compromised mice. [PDF]

Neuroimage, 2023
Mandeville JB, Weigand-Whittier J, Wey HY, Chen YI.   +3 more
europepmc   +1 more source

Studies on the interactions of retinal dopamine with choroidal thickness in the chicken. [PDF]

Graefes Arch Clin Exp Ophthalmol, 2023
Mathis U, Feldkaemper M, Liu H, Schaeffel F.   +3 more
europepmc   +1 more source

Pharmacological characterization of binding sites identified in rat brain following in vivo administration of [³H]‐spiperone. [PDF]

, 1987
J K Chivers, Peter Jenner, C. D. Marsden
openalex   +1 more source