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The postpartum uterus reveals compartment-specific remodeling processes with distinct immune signatures. [PDF]

open access: yesFront Immunol
Waldmann A   +7 more
europepmc   +1 more source
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Unraveling the mysteries of spiral artery remodeling

Placenta, 2023
Spiral artery remodeling is the process by which the uterine vessels become large bore low resistance conduits, allowing delivery of high volumes of maternal blood to the placenta to nourish the developing fetus. Failure of this process is associated with the pathophysiology of most of the major obstetric complications, including late miscarriage ...
Gendie Lash
exaly   +3 more sources

Role of osteopontin (OPN) in uterine spiral artery remodeling

Placenta, 2022
Uterine spiral artery (SpA) remodeling is critical for a successful pregnancy. The deficiency of SpA remodeling seriously affects the blood perfusion of the placenta, impacting the nutritional supply to the fetus and therefore fetal growth and development, which is one of the pathological causes of pregnancy related diseases.
Gendie Lash, Miaojuan Chen
exaly   +3 more sources

Spiral artery remodeling and maternal cardiovascular risk

Journal of Hypertension, 2016
Women with a history of placental bed disorders, including preeclampsia and intrauterine growth restriction have an increased long-term risk of cardiovascular disease (CVD). Further, similarities exist between atherosclerosis and abnormalities observed in placental bed spiral arteries in pregnancies affected by preeclampsia and intrauterine growth ...
Jan H W, Veerbeek   +7 more
openaire   +2 more sources

Endovascular trophoblast and spiral artery remodeling

Molecular and Cellular Endocrinology, 2020
Spiral artery remodeling, which is indispensable for successful pregnancy, is accomplished by endovascular trophoblasts that move upstream along the arterial wall, replace the endothelium, and disrupt the muscular lining. This review outlines the possible factors that could regulate endovascular trophoblast differentiation and invasion.
openaire   +2 more sources

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