Reaction of 2-Benzoyl-1,2-Dihydroisoquinoline-1-Carbonitrile Tetrafluoroborate Salt with 2-Arylmethylene-1,3-Indanediones. Regio- and Stereochemistry of the Reaction. Formation of Spiro Compounds [PDF]
, 2003 Sarra Boudriga +3 more
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Asymmetric Synthesis of Propargylic and Allenic Silanes, Germanes, and Stannanes
Chemistry – An Asian Journal, EarlyView.Organotetrel compounds are important reagents with broad applications in chemical industries and natural product synthesis. This review provides a summary of strategies for the synthesis of propargylic and allenic organotetrels in their enantioenriched forms.
Hai Chang, Ruihan Wang, Yi‐Ming Wang
wiley +1 more source
2-Azidobenzaldehyde-Based [4+2] Annulation for the Synthesis of Quinoline Derivatives
MoleculesQuinoline is a privileged heterocyclic ring which can be found in many drug molecules and bioactive compounds. The development of synthetic methods for making quinoline derivatives continuously attracts the interest of organic and medicinal chemists ...
Xiaofeng Zhang +3 more
doaj +1 more source
Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants. [PDF]
, 2019 Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by many loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, including N1303K. We previously introduced the
Finkbeiner, Walter E +7 more
core
Intramolecular Cyclization with Nitrenium Ions Generated by Treatment of N‐Acylaminophthalimides with Hypervalent Iodine Compounds: Formation of Lactams and Spiro‐Fused Lactams. [PDF]
, 2003 Yasuo Kikugawa +4 more
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Chemistry – An Asian Journal, EarlyView.Regioselective ring‐opening cyclization of spirocyclopropanes with NaSH proceeded smoothly, and subsequent addition of an acid afforded tetrahydrobenzo[b]thiophen‐4‐ones that could be converted into the 4‐hydroxybenzo[b]thiophenes. This protocol provides an alternative synthetic method to access benzo[b]thiophenes without using multisubstituted ...
Hisanori Nambu +5 more
wiley +1 more source
Investigations on the Reactivity of Bis(bromomagnesio)trimethylsilylmethane − Molecular Structure of a Tebbe‐Type Spiro‐Organomagnesium Compound [PDF]
, 2004 M. Hogenbirk +6 more
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Chemistry – An Asian Journal, EarlyView.Radical cation species of cyclic [n]spirobifluorenylene (n = 4, 5) with bulky alkyl groups at the termini were synthesized to investigate the relationship between the number of perpendicular π‐conjugated units and electron transfer behavior. Both calculations and experiments revealed that the extent of electron delocalization increased as the ring size
Tomoya Imai, Toru Amaya
wiley +1 more source
Syntheses and medicinal chemistry of spiro heterocyclic steroids
Beilstein Journal of Organic ChemistryThere is compelling evidence that incorporating a heterocyclic moiety into a steroid can alter its pharmacological and pharmacokinetic properties, driving intense interest in the synthesis of such hybrids among research groups. In this review, we present
Laura L. Romero-Hernández +5 more
doaj +1 more source
N‐Heterocyclic Carbene Catalyzed Reaction of Enals and 1,2‐Dicarbonyl Compounds: Stereoselective Synthesis of Spiro γ‐Butyrolactones. [PDF]
, 2006 Vijay Nair +4 more
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