Results 131 to 140 of about 50,141 (259)

Efficacy and Safety of Low‐Dose Spironolactone in Management of Diabetic Kidney Disease in a Real‐World Setting

Endocrinology, Diabetes & Metabolism
Background Adding spironolactone to renin‐angiotensin‐aldosterone system (RAAS) blockers has been shown to reduce albuminuria in patients with diabetic kidney disease (DKD). However, the increased risk of hyperkalaemia is a major concern.
Manochehr Amini, Davood Dalil, Fatemeh Yaghoubi, Zoleykha Valizadeh, Farnaz Tavakoli, Zohreh Koohpayezadeh   +5 more
doaj   +1 more source

Eplerenone improves kidney function and cardiac performance in obese male mice

Diabetic Medicine, Volume 43, Issue 1, January 2026.
Abstract Aims Renin‐angiotensin‐aldosterone system (RAAS) activation mediates obesity‐associated cardiorenal dysfunction. Due to an incomplete understanding of the molecular mechanisms, the clinical use of RAAS antagonism in obesity‐associated cardiometabolic complications remains uncertain.
Ayman K. Banah, Bingxue Qi, Ryan Koh, Alexander Lawlor, Tianzhen Wang, Vishal Musale, Joanne Mains, Colin E. Murdoch, Li Kang   +8 more
wiley   +1 more source

Regular Medications Administered to Older Adults in Aged Care Facilities: A Retrospective Descriptive Study

Journal of Clinical Nursing, Volume 35, Issue 1, Page 363-374, January 2026.
ABSTRACT Aim(s) To explore which regularly prescribed medications are most commonly administered to older adults in aged care facilities in Australia, by whom and when, and to identify the prevalence of polypharmacy in this population group. Design Retrospective descriptive study.
Stephanie M. Garratt, Maneesh Prasad, Kelly Ottosen, Elizabeth Manias   +3 more
wiley   +1 more source

P2501Rivaroxaban combined with spironolactone attenuates cardiovascular remodeling due to hypoxia in pulmonary arterial hypertension [PDF]

, 2018
Tatsuya Hayashi, Sen Matsumoto, Akiyo Hosokawa, Kazutoshi Yamamoto, Atsuo Nomura, Eiki Woo, Hideki Imano, Ryuji Kato, Yoshio Ijiri, Takehiro Yamaguchi, Yoko Izumi, M. Yoshiyama, Yasunori Okada, Michio Asahi   +13 more
openalex   +1 more source

Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in male mice

The Journal of Physiology, Volume 604, Issue 1, Page 172-192, 1 January 2026.
Abstract figure legend Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in aged male mice. Global deletion of ASIC1a (Asic1a−/−) in adult male mice (6 months old) elevates corticosterone, leading to hypokalaemia, volume expansion, increased pulse pressure and cardiomyocyte hypertrophy.
Selina M. Garcia, Megan N. Tuineau, Xavier A. DeLeon, Neil D. Detweiler, Shristey Tamang, Nancy L. Kanagy, Laura V. Gonzalez Bosc, Thomas C. Resta, Jay S. Naik, Nikki L. Jernigan   +9 more
wiley   +1 more source

The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol

Canadian Journal of Kidney Health and Disease
Background: The mineralocorticoid aldosterone may contribute to the risk of cardiovascular morbidity and mortality in patients receiving maintenance dialysis. Whether spironolactone, a mineralocorticoid receptor antagonist, improves outcomes for patients
Michael Walsh, David Collister, Martin Gallagher, Patrick B. Mark, Janak R. de Zoysa, Jessica Tyrwhitt, Karthik Tennankore, Laura Sola, Gilmar Reis, Denis Xavier, Russell Villanueva, Wen J. Liu, Camilo Félix, Li Zuo, Mustafa Arici, Vivekanand Jha, Ron Wald, Amanda Y. Wang, Atiya R. Faruqui, Fei Yuan, Shun Fu Lee, Alena Kuptsova, Courtney Christou, P. J. Devereaux,   +24 more
doaj   +1 more source

The Use of Tranexamic Acid to Treat Melasma: A Systematic Review and Meta‐Analysis

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Introduction Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits bleeding due to its effects on plasminogen conversion, approved by the FDA to treat menorrhagia and prevent bleeding in hemophilia patients undergoing dental extraction.
Nabila Scabine Pessotti, Vinicius Tassoni Civile, Talita Andrade Brandao, Felipe Ribeiro, Gisele Viana de Oliveira, Nathalia Sernizon Guimarães, Denise Steiner, Mahlatse Kgokolo   +7 more
wiley   +1 more source

Drug interaction study in hospitalized hepatic cirrhosis patient in Dr.Ramelan navy hospital [PDF]

, 2009
Cirrhotic liver lead to some changes in pathophysiology such as reduction in liver blood flow, decrease some metabolic and synthetic function of the liver. Also there is a change in endothelial lining from hepatic sinusoid.
., Widyati, Bagijo, Hary, Hubeis, A. Aziz., Lorensia, Amelia   +3 more
core  

Effect of Spironolactone on Diastolic Function and Left Ventricular Mass in Maine Coon Cats with Familial Hypertrophic Cardiomyopathy [PDF]

, 2008
Kristin A. MacDonald, Mark D. Kittleson, P.H. Kass   +2 more
openalex   +1 more source

Targeting efficacy of spironolactone in patients with heart failure with preserved ejection fraction: the TOPCAT study

, 2022
Huimin Zhou, Rongjian Zhan, Xuanyu Chen, Yi‐fen Lin, Shaozhao Zhang, Huigan Zheng, Xueqin Wang, M. Liu M. Li D. Huang, Chao‐guang Xu, Xinxue Liao, Ting Tian, Xiaodong Zhuang   +11 more
openalex   +1 more source