Results 171 to 180 of about 3,654 (228)

Chemo- and Diastereoselective Synthesis of Spirooxindole-pyrazolines and Pyrazolones via P(NMe2)3-Mediated Substrate-Controlled Annulations of Azoalkenes with α-Dicarbonyl Compounds.

Organic Letters, 2023
P(NMe2)3-mediated substrate-controlled annulations of azoalkenes with α-dicarbonyl compounds are reported, where the azoalkenes serve as either four or five-atom synthons chemoselectively.
Yunfeng Du, Yuefei Liu, Hongyu Guo, Rongfang Liu, R. Zhou   +4 more
semanticscholar   +1 more source

Expeditious entry into carbocyclic and heterocyclic spirooxindoles

Organic & Biomolecular Chemistry, 2022
Recent advances in the chemistry of base-, metal-, nano-metal and organo-catalyst mediated achiral and chiral versions of the structurally diverse and pharmaceutically relevant spirooxindoles are gently reviewed.
Madhu Ganesh, Shammy Suraj
openaire   +2 more sources

Organocatalytic Asymmetric [4 + 2]-Cycloadditions of 2-Aminophenyl Enones with Isatin-Derived Ketimines: Diastereo- and Enantioselective Synthesis of Spirooxindole-Tetrahydroquinazolines.

Organic Letters, 2023
A novel method for the enantioselective synthesis of spiro N,N-heterocyclic oxindoles has been developed, employing asymmetric [4 + 2]-cycloadditions of 2-aminophenyl enones with isatin-derived ketimines.
Ji Won Han, Yoseop Kim, Sung-Gon Kim
semanticscholar   +1 more source

Organocatalytic Asymmetric Synthesis of Spirooxindole Embedded Oxazolidines [PDF]

The Journal of Organic Chemistry, 2021
The first organocatalytic asymmetric synthesis of spirooxindole embedded oxazolidines has been developed via a domino reaction involving hemiaminal formation, followed by an unprecedented aza-Michael reaction between isatin derived N-Boc ketimines and γ-hydroxy enones.
Chandrakanta Parida, Buddhadeb Mondal, Animesh Ghosh, Subhas Chandra Pan   +3 more
openaire   +2 more sources

Asymmetric Metal‐Templated Approach to Amino Acids with a CF3‐Containing 3,2’‐Pyrrolidinyl Spirooxindole Core via a Michael/Mannich [3+2]‐Cycloaddition Reaction

Advanced Synthesis & Catalysis, 2023
We report here a practical protocol for the asymmetric synthesis of AAs with a CF3‐containing 3,2’‐pyrrolidinyl spirooxindole skeleton with three defined carbon stereocenters via a sequential Michael/Mannich [3+2]‐cycloaddition reaction.
Z. Gugkaeva, M. Stukalova, Alexander Smolyakov, A. Tsaloev, V. Maleev, V. Larionov   +5 more
semanticscholar   +1 more source

Ammonium acetate mediated simple, rapid, and one-pot multicomponent synthesis of spirooxindole derivatives

Synthetic Communications, 2023
Synthesis of spirooxindole derivatives was achieved by combining Knoevenagel condensation and Michael addition between isatin, malononitrile, and dimedone or cyclohexan-1,3-dione in presence of ammonium acetate by simple stirring in ethanol at room ...
Barkha K. Raheja, D. Dalal
semanticscholar   +1 more source

Stereoselective Synthesis of Highly Functionalized Aminobenzothiazole-Fused Spirooxindole Derivatives: in silico and in vitro Anti-Diabetic Studies

Synthesis, 2023
A higly functionalized spirooxindole pyrrolizidine/pyrrolothiazole derivatives has been synthesised by the three-component 1,3-dipolar cycloaddition reaction of benzothiazolyl amides with isatin-based azomethine ylides.
Narayanasamy Nivetha, Shashank M. Patil, R. Ramu, S. Sreenivasa, S. Velmathi   +4 more
semanticscholar   +1 more source

ChemInform Abstract: A New Route to Spirooxindoles.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tim C. T. Ho, Goran Pljevaljcic, Stephen T. Hilton, Keith Jones   +3 more
openaire   +4 more sources

ChemInform Abstract: Strategies for the Enantioselective Synthesis of Spirooxindoles.

ChemInform, 2012
AbstractReview: 85 refs.
Nicolas R. Ball-Jones, Annaliese K. Franz, Joseph J. Badillo   +2 more
openaire   +4 more sources

Substrate-Controlled Regioselectivity Switchable [3 + 2] Annulations To Access Spirooxindole Skeletons.

Journal of Organic Chemistry, 2022
The additive-free [3 + 2] annulation from isatins, amino acids with 2-styrylbenzoxazoles, was described, providing a series of functional and structurally complex 3,3'-pyrrolidinyl-spirooxindole derivatives containing four contiguous and two quaternary ...
Kaikai Wang, Yanli Li, Rongxiang Chen, Zhanyong Wang, Ninglin Li, Luyan Zhang, S. Gu   +6 more
semanticscholar   +1 more source