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Organocatalytic Asymmetric Synthesis of Spirooxindole Embedded Oxazolidines
The Journal of Organic Chemistry, 2021The first organocatalytic asymmetric synthesis of spirooxindole embedded oxazolidines has been developed via a domino reaction involving hemiaminal formation, followed by an unprecedented aza-Michael reaction between isatin derived N-Boc ketimines and γ-hydroxy enones.
Chandrakanta Parida +3 more
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Molecular diversity of spirooxindoles. Synthesis and biological activity
Molecular Diversity, 2015Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work.
Tetyana L, Pavlovska +3 more
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Superacid-Promoted synthesis of spirooxindoles
Tetrahedron Letters, 2023Jacob C. Hood +2 more
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Catalytic asymmetric synthesis of spirooxindoles: recent developments
Chemical Communications, 2018The past four years have witnessed significant developments in the field of the catalytic asymmetric synthesis of spirooxindoles, and this feature article outlines the recent progress in this area, including the contributions of our group. This article is divided into sections according to the size and type of the generated spiro-ring fused at the C3 ...
Guang-Jian Mei, Feng Shi
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Titanium-Catalyzed Stereoselective Synthesis of Spirooxindole Oxazolines
Organic Letters, 2010A regio- and stereoselective cyclization between isatins and 5-methoxyoxazoles has been developed using catalytic titanium(IV) chloride (10 or 20 mol %) to afford spiro[3,3'-oxindoleoxazolines] in excellent yield (up to 99%) and diastereoselectivity (dr >99:1). Substitution at the 4-position of the oxazole controls nucleophilic attack to provide either
Joseph J, Badillo +3 more
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