Advanced Synthesis &Catalysis, Volume 366, Issue 24, Page 5008-5014, December 17, 2024.Abstract In this work, we present an organocatalytic spiroannulation method that provides access to spirocyclic benzofuran‐2‐ones. The reaction proceeds via the generation of an azolium dienolate from an α‐bromo‐α,β‐unsaturated aldehyde using a chiral N‐heterocyclic carbene, followed by annulation with benzofuran‐2‐one‐derived alkenes.
Ladislav Lóška +8 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 27, Issue 41, November 4, 2024.A diaminomethylenemalononitrile organocatalyst promoted asymmetric cascade Michael/Michael reactions between a 2‐(trifluoromethylmethylene)indane‐1,3‐dione derivative and α‐alkylidene succinimides, resulting in spiroindane‐1,3‐dione derivatives.
Ryo Tsuyusaki +4 more
wiley +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic
Sara T. Al-Rashood +7 more
doaj +1 more source
Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
Beilstein Journal of Organic Chemistry, 2012 A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields.
Chunhui Dai +2 more
doaj +1 more source
Spirooxadiazoline oxindoles: synthesis and evaluation of anticancer and antimalarial activities [PDF]
, 2017 Cancer is one of the modern world’s most common and deadly non-infectious disease. According to WHO Cancer Report of 2015, it is one of leading causes of morbidity and mortality worldwide with 8.8 million deaths in 2015 and it is expected to rise about ...
Lopes, Elizabeth de Abreu
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The therapeutic potential of small molecules p53-MDM protein-protein interaction inhibitors [PDF]
, 2016 Tese de mestrado, Ciências Biofarmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016Ao longo dos anos, vários estudos científicos têm comprovado a importância da proteína supressora de tumor p53 na homeostase celular.
Nunes, Rute Cláudia Correia Sacadura
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Part A: Palladium(II)-Catalyzed Enantioselective Saucy-Marbet Claisen Rearrangement of Propargyloxy indoles to Quaternary Oxindoles and Spirocyclic Lactones. Part B: The Regioselective Oxidative Coupling of Phenols . [PDF]
, 2013 Part A. The first catalytic, enantioselective Saucy-Marbet Claisen rearrangement has been developed. Palladium(II) catalysts with BINAP or t-BuPHOX ligands were discovered as superior in catalyzing Claisen rearrangements of proparyloxy-substituted ...
Cao, Trung Duy Chi
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Molecular diversity of spirooxindoles. Synthesis and biological activity [PDF]
, 2016 Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the ...
Atamanuk, D. V. +11 more
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Recent advances of azomethine ylides for the synthesis of natural and synthetic bioactive pyrrolidines and spiropyrrolidines. [PDF]
RSC AdvPaira P +4 more
europepmc +1 more source
Base-Mediated Tandem Michael Addition and SuFEx Cyclization for the Synthesis of Sultone-Containing Spirooxindoles. [PDF]
ACS OmegaGovender KB +6 more
europepmc +1 more source