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Spirooxindoles as Potential Pharmacophores
Mini-Reviews in Medicinal Chemistry, 2017The spiroindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Over the past few decades, various spiroindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
Prabhu Mohapatra +2 more
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Therapeutic Potential of Spirooxindoles as Antiviral Agents [PDF]
ACS Infectious Diseases, 2016 Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low toxicity remain challenging, and obtaining such agents continues to be an active area of therapeutic development. Due to their unique three-dimensional structural features, spirooxindoles have been identified as privileged chemotypes for antiviral drug ...
Pei-Yong Shi, Eric A Wold, Jia Zhou
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Expeditious entry into carbocyclic and heterocyclic spirooxindoles
Organic & Biomolecular Chemistry, 2022Recent advances in the chemistry of base-, metal-, nano-metal and organo-catalyst mediated achiral and chiral versions of the structurally diverse and pharmaceutically relevant spirooxindoles are gently reviewed.
Madhu Ganesh, Shammy Suraj
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Enantioselective Construction of Spirooxindole-Fused Cyclopentanes
The Journal of Organic Chemistry, 2021The present study reports an asymmetric organocatalytic cascade reaction of oxindole derivates with α,β-unsaturated aldehydes efficiently catalyzed by simple chiral secondary amine. Spirooxindole-fused cyclopentanes were produced in excellent isolated yields (up to 98%) with excellent enantiopurities (up to 99% ee) and moderate to high ...
Vojtěch Dočekal +7 more
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Spirooxindoles: Promising scaffolds for anticancer agents
European Journal of Medicinal Chemistry, 2015The search for novel anticancer agents with more selectivity and lower toxicity continues to be an area of intensive investigation. The unique structural features of spirooxindoles together with diverse biological activities have made them privileged structures in new drug discovery.
Hong-Min Liu, Bin Yu, De-Quan Yu
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Organic Letters, 2000
[reaction: see text]Reaction of indole amides 5 with tributylstannane gave spiroindolenines 9 which are readily converted into spiropyrrolidinyloxindoles. This tricyclic system is found in a number of interesting natural products.
S T, Hilton +3 more
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[reaction: see text]Reaction of indole amides 5 with tributylstannane gave spiroindolenines 9 which are readily converted into spiropyrrolidinyloxindoles. This tricyclic system is found in a number of interesting natural products.
S T, Hilton +3 more
openaire +2 more sources
Strategies for the enantioselective synthesis of spirooxindoles
Organic & Biomolecular Chemistry, 2012Oxindoles and spirooxindoles are important synthetic targets that are often considered to be prevalidated with respect to their biological activity and applications for pharmaceutical lead discovery. This review features efficient strategies for the enantioselective synthesis of spirocyclic oxindoles, focusing on reports in 2010 and 2011.
Nicolas R, Ball-Jones +2 more
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Diastereoselective Synthesis and Structure of Spirooxindole Derivatives
HETEROCYCLES, 2003Spiroindolinonisoxazolines (4 and 5h) are prepared from (E)- 1 or (Z)-3-arylidene-2-oxindoles (2) by nitrile oxide cycloaddition reactions. Only one regioisomer is detected in all cases, and the observed complete diastereoselection is established by unambigous structural assignments.
RISITANO, Francesco +4 more
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An Access to Highly Functionalized Dihydrobenzofuran Spirooxindole Scaffolds
Organic Letters, 2022We have developed an efficient protocol for the construction of polycyclic dihydrobenzofuran spirooxindole scaffolds via base promoted cascade annulation of Morita-Baylis-Hillman (MBH) carbonates of isatins with ortho-hydroxychalcones or ortho-hydroxy-β-nitrostyrenes. The complex polycyclic compounds were conveniently synthesized in satisfactory yields
Daqian Wang +4 more
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Recent Strategies in the Synthesis of Spiroindole and Spirooxindole Scaffolds
Topics in Current Chemistry, 2021Spiroindole and spirooxindole scaffolds are very important spiro-heterocyclic compounds in drug design processes. Significant attention has been directed at obtaining molecules based on spiroindole and spirooxindole derivatives that have bioactivity against cancer cells, microbes, and different types of disease affecting the human body.
Shima Nasri +2 more
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