Results 91 to 100 of about 1,205 (207)

Diastereoselective ABB′ Three-Component Synthesis of Highly Functionalized Spirooxindoles Bearing Five Consecutive Asymmetric Carbons

, 2019
The synthesis of spirooxindoles bearing tetrahydro-4H-cyclopenta­[b]­furan framework was established starting from isatin-derived aldehydes and 2 equiv of 1,3-dicarbonyl compounds involving a piperidine-catalyzed ABB′ three-component domino process. This
Muthu Karuppasamy, Isravel Muthukrishnan (1393186), Subbiah Nagarajan, B. S. Vachan (6495611), B. S. Vachan, Isravel Muthukrishnan, Thavaraj Vivekanand, Vellaisamy Sridharan (564774), Vellaisamy Sridharan, Thavaraj Vivekanand (1393174), C. Uma Maheswari (1393177), C. Uma Maheswari, Muthu Karuppasamy (3193683), Nattamai Bhuvanesh (765163), Subbiah Nagarajan (1393183), Nattamai Bhuvanesh   +15 more
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Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic
Sara T. Al-Rashood, Ahmed R. Hamed, Ghada S. Hassan, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Amal Alharbi, Mohammad M. Al-Sanea, Wagdy M. Eldehna   +7 more
doaj   +1 more source

Asymmetric Synthesis of Spirooxindoles via Nucleophilic Epoxidation Promoted by Bifunctional Organocatalysts

Molecules, 2018
Taking into account the postulated reaction mechanism for the organocatalytic epoxidation of electron-poor olefins developed by our laboratory, we have investigated the key factors able to positively influence the H-bond network installed inside the ...
Martina Miceli, Andrea Mazziotta, Chiara Palumbo, Elia Roma, Eleonora Tosi, Giovanna Longhi, Sergio Abbate, Paolo Lupattelli, Giuseppe Mazzeo, Tecla Gasperi   +9 more
doaj   +1 more source

Nouvelles voies d'accès aux clyclopentènes spirooxindoles : activation d'allényl sulfones par des paires d'ions sulfinate ammonium

, 2020
This PhD work concerns the use of sulfinate anions (RSO2–) as catalysts, within sulfinate/ammonium ion pairs RSO2/NR4, in organocatalyzed annelation processes leading to biologically relevant cyclopentene spirooxindoles. The methodologies involve anionic
Martin, Victorien
core  

Asymmetric synthesis of druglike six-membered spirooxindoles through an amino enyne catalysis

, 2013
An effective reflexive-Michael (r-M) reaction has been disclosed to access drug-like six-membered spirooxindoles in good yields and excellent enantioselectivities by using an aminoenyne-catalysis.
R. Madhavachary, Ramachary, D. B., D. B. Ramachary, Madhavachary, R., Chintalapudi Venkaiah, Venkaiah, Chintalapudi   +5 more
core   +1 more source

Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization

Beilstein Journal of Organic Chemistry, 2012
A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields.
Chunhui Dai, Bo Liang, Corey R. J. Stephenson   +2 more
doaj   +1 more source

Original accesses to cyclopentene spirooxindoles : activation of allenyl sulfones by sulfinate ammonium ion pairs

, 2020
Les travaux décrits dans cette thèse ont pour fil conducteur l’exploitation des paires d’ions sulfinate/ammonium RSO2–/+NR4, à travers des réactions d’annélation permettant d’accéder à des cyclopentènes spirooxindoles.
Martin, Victorien
core  

Catalyst free, multicomponent-tandem synthesis of spirooxindole-indazolones and spirooxindole-pyrazolines: a glycerol mediated green approach

RSC Advances, 2015
The development of a versatile new one pot, catalyst free, multicomponent-tandem strategy for assembly of spirooxindole-indazolones and spirooxindole-pyrazolines is described.
Swastika Singh, Mohammad Saquib, Shyam Babu Singh, Mandavi Singh, Jagdamba Singh   +4 more
openaire   +1 more source

Selective Synthesis of Spirooxindoles by an Intramolecular Heck–Mizoroki Reaction

, 2017
We report a highly diastereoselective synthesis of cydopentene-spirooxindole derivatives via an intramolecular Heck-Mizoroki reaction using aryl bromides as precursors. The reactions were performed under dry conditions or in a DMF-water system.
Wetzel, Alexander,, Alexander Wetzel, Peter Brandt, Bergman, Joakim,, Larhed, Mats,, Sävmarker, Jonas,, Tamal Roy, Joakim Bergman, Brandt, Peter,, Branalt, Jonas,, Mats Larhed, Roy, Tamal,, Jonas Brånalt, Jonas Sävmarker   +13 more
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Dehydrative Transformation of Spirooxindoles to Pyrido[2,3‑b]indoles via POCl₃

, 2019
A two-step one-pot efficient synthesis of pyrido­[2,3-b]­indoles via reaction between isatin, α-amino acid, and dipolarophile has been developed. The initial 1,3-dipolar cycloaddition between the reactants that is performed in the presence of either CuI ...
Aritra Ghosh (581661), Sanjay Batra (1613422), Dinesh S. Barak (6489884), Vandana Jaiswal (754875), Shivalinga Kolle (6489881), Ruchir Kant (1433839)   +5 more
core   +2 more sources