Results 71 to 80 of about 1,887 (208)

Organocatalyzed Asymmetric Reaction Using α-Isothiocyanato Compounds [PDF]

, 2016
Organocatalyzed asymmetric reaction using α-isothiocyanato compounds has received much attention in the past 5 years, and significant progress has been made for three types of isothiocyanato compounds, including α-isothiocyanato amides, esters, and ...
Chen, Yong-Zheng, Cui, Bao-Dong, Han, Wen-Yong, Xu, Xiao-Ying, Yuan, Wei-Cheng   +4 more
core   +2 more sources

Diastereoselective Formal 1,3-Dipolar Cycloaddition of Trifluoroethyl Amine-Derived Ketimines Enables the Desymmetrization of Cyclopentenediones

Molecules, 2023
In this research, a metal-free diastereoselective formal 1,3-dipolar cycloaddition of N-2,2,2-trifluoroethylisatin ketimines and cyclopentene-1,3-diones which can efficiently lead to the desymmetrization of cyclopentene-1,3-diones is developed.
Lin-Qiang Li, Jian-Qiang Zhao, Yan-Ping Zhang, Yong You, Zhen-Hua Wang, Zhen-Zhen Ge, Ming-Qiang Zhou, Wei-Cheng Yuan   +7 more
doaj   +1 more source

Regioselective Synthesis of Spiro-Oxindoles via a Ruthenium-Catalyzed Metathesis Reaction

Chemistry Proceedings, 2023
Spiro-oxindoles are important heterocyclic motifs found in various alkaloids, many of which exhibit pharmacological properties. Due to the remarkable biological activity of spiro-oxindoles, significant effort has been made towards the synthesis of ...
Pradip Debnath
doaj   +1 more source

Green Synthesis of Spiro Compounds with Potential Anticancer Activity through Knoevenagel/Michael/Cyclization Multicomponent Domino Reactions Organocatalyzed by Ionic Liquid and Microwave-Assisted [PDF]

, 2022
In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride as catalyst was developed for the synthesis of spiro compounds.
Campos V. R., Fiorot R. G., Greco S. J., Guimaraes C. D. J., Loureiro L. B., Manso M. P., Medici F., Pessoa C., Resende J. A. L. C., Tormena C. F., Venturini Filho E., Westphal R.   +11 more
core   +1 more source

Catalytic Asymmetric Synthesis of gem‐Dicyano‐Spirocyclopropyl Oxindoles by N‐9‐Anth‐PyBidine‐Co(OAc)2: Advantage of Three‐Component Coupling Approach

ChemistryEurope, Volume 4, Issue 3, March 2026.
Chiral gem‐dicyano‐spirocyclopropyl oxindoles are obtained by a chiral N‐9‐Anth‐PyBidine‐Co(OAc)2‐catalyzed asymmetric Michael/alkylation reaction of 3‐chlorooxindoles with alkylidenemalononitriles. The three‐component coupling reaction of 3‐chlorooxindoles, aldehydes, and malononitrile shows the advantage of not requiring the preparation of ...
Takaaki Saito, Ren Miyasaka, Kazumasa Kon, Yuri Takagi, Takayoshi Arai   +4 more
wiley   +1 more source

Efficient and green pathway for one-pot synthesis of spirooxindoles in the presence of CuO nanoparticles

Green Chemistry Letters and Reviews, 2017
In this research, a new, green and eco-friendly method for the synthesis of spirooxindole derivatives was presented. The reaction was performed at room temperature in the presence of catalytic amounts (4 mol.%) of CuO nanoparticles and products were ...
Leila Moradi, Zeynab Ataei
doaj   +1 more source

A novel one-pot synthesis of spirooxindole derivatives catalyzed by nano ZnO

Bulletin of the Chemical Society of Ethiopia, 2013
Nano zinc oxide was explored as a heterogeneous and reusable catalyst for the one-pot synthesis of spirooxindoles via three-component reaction between urea, isatin, and 1,3-dicarbonyl compounds.
B. Baghernejad, M. Khorshidi
doaj   +1 more source

Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity [PDF]

, 2022
© 2022 Published by Elsevier Masson SAS.Malaria remains a prevalent infectious disease in developing countries. The first-line therapeutic options are based on combinations of fast-acting artemisinin derivatives and longer-acting synthetic drugs. However,
Fontinha, Diana, Legac, Jenny, Lehane, Adele M., Lopes, Elizabeth A., Mestre, Raquel, Mori, Mattia, Pei, Jinxin V., Prudêncio, Miguel, Rosenthal, Philip J., Sanches-Vaz, Margarida, Santos, Maria M. M.   +10 more
core   +1 more source

Next‐Generation Proteolysis‐Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs)‐mediated protein degradation has been recently developed as a game‐changing approach in oncology drug development. It represents a paradigm shift from traditional enzyme inhibition to selective protein degradation.
Mohamed S. Nafie, Mohamed K. Diab, Asmaa S. A. Yassen, Amany M. Elshamy, Mohamed R. El Tohamy, Haytham O. Tawfik, Sherif Ashraf Fahmy   +6 more
wiley   +1 more source

Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

ChemistryEurope, Volume 3, Issue 5, September 18, 2025.
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés, Birane Diop, Xingyu Jiang, Jean Rodriguez, Muriel Amatore, Thierry Constantieux   +5 more
wiley   +1 more source