Results 81 to 90 of about 1,205 (207)

From data to discovery: leveraging big data in plant natural products biosynthesis research

The Plant Journal, Volume 122, Issue 6, June 2025.
SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie, Tuan‐Anh Minh Nguyen, Truc Kim, Trinh‐Don Nguyen, Thu‐Thuy T. Dang   +4 more
wiley   +1 more source

Computational Design, Synthesis, and Biological Assessment of Some Pyrrolo[3,4‐c]Pyrroles Targeting Mycobacterium Tuberculosis

ChemistrySelect, Volume 10, Issue 17, May 5, 2025.
A new set of spirooxindole‐ and spiroindenoquinoxaline‐derived pyrrolo[3,4‐c] pyrroles has been synthesized through atom‐economic one‐pot multicomponent reactions. Based on the results, compounds 4b and 5a demonstrated promising Glide scores and exhibited strong binding affinity with decaprenylphosphoryl‐β‐D‐ribofuranose oxidoreductase.
Mathiyazhagan Lavanya, Rajamanikandan Sundararaj, Kailasam Saravana Mani, Krishnakumar Balu, Mani Durai, Perwez Alam, Priya SD, Mathivanan Durai, Young Ho Ahn   +8 more
wiley   +1 more source

Metal-free diastereoselective construction of bridged ketal spirooxindoles via a Michael addition-inspired sequence

, 2017
A TfOH-catalyzed highly diastereoselective Michael addition/ketalization sequence of 3-hydroxyoxindoles and ortho-hydroxychalcones was developed, leading to biologically important bridged ketal spirooxindoles in moderate to excellent yields.
Shaojing Jin, Jiaomei Guo, Qilin Wang, Huahui Dong, Xuguan Bai, Yanshuo Zhu, Jing Zhou, Zhanwei Bu   +7 more
core   +1 more source

Recent Advancements in the Cyclization Strategies of 1,3‐Enynes Towards the Synthesis of Heterocyclic/Carbocyclic Frameworks

Chemistry – An Asian Journal, Volume 20, Issue 8, April 17, 2025.
In this review, the advancements in the cyclization of 1,3‐enynes to construct structurally diverse heterocyclic and carbocyclic frameworks are portrayed comprehensively. Divergent cyclization protocols along with mechanistic aspects for key transformations are also detailed. Abstract 1,3‐Enynes have demonstrated their utility as valuable precursors to
Akash P. Sakla, Shams Aaghaz, Shujauddin Ahmed, Naziya Neshat, Ahmed Kamal   +4 more
wiley   +1 more source

A thermally-induced, tandem [3,3]-sigmatropic rearrangement/[2 + 2] cycloaddition approach to carbocyclic spirooxindoles

Beilstein Journal of Organic Chemistry, 2010
The synthesis of C3-carbocyclic spirooxindoles was realized by way of an intramolecular [2 + 2] cycloaddition reaction between a vinylidene indolin-2-one and an alkyne.
Kay M. Brummond, Joshua M. Osbourn
doaj   +1 more source

Cooperative Vinylogous Enamine and Metal Catalysis

ChemCatChem, Volume 17, Issue 7, April 4, 2025.
This review describes transformations combining vinylogous enamine catalysis with transition metal or Lewis acid catalysis that have emerged since the seminal report of dienamine catalysis in 2006. These transformations span numerous reaction classes, including alkylation, allylation, propargylation, oxyamination, dimerization, as well as cascade ...
Stacey E. Brenner‐Moyer
wiley   +1 more source

Microwave‐Assisted Multicomponent Synthesis of Spirooxindole Dihydropyridine Bisphosphonates

European Journal of Organic Chemistry, Volume 28, Issue 6, February 10, 2025.
A new, simple, catalyst‐ and solvent‐free microwave‐assisted multicomponent method was developed for the synthesis of spirooxindole dihydropyridine bisphosphonates as a new family of compounds by the one‐pot reaction of isatins, β‐ketophosphonates and primary amines.
Bettina Rávai, Áron Soma Németh, Zsolt Kelemen, Erika Bálint   +3 more
wiley   +1 more source

Diastereoselective synthesis of cyclopentanone-fused spirooxindoles by N-heterocyclic carbene-catalyzed homoenolate annulation with isatilidenes

, 2015
N-Heterocyclic carbene (NHC)-catalyzed formal [3 + 2] annulation of α,β-unsaturated aldehydes with N-substituted isatilidenes resulting in the diastereoselective synthesis of cyclopentanone-fused spirooxindoles is demonstrated.
Gonnade, Rajesh G., Yetra, Santhivardhana Reddy, Patra, Atanu, Bhunia, Anup, Biju, Akkattu T.   +4 more
core   +1 more source

Discovery, bioactivities and biosynthesis of spirooxindole alkaloids

Natural Product Reports
This review provides a comprehensive summary of the origin, activities, and biosynthesis of spirooxindole-containing alkaloids derived from a variety of organisms, including actinomycetes, cyanobacteria, fungi, plants, and invertebrates.
Ruijie Chen, Lihan Zhang, Xiaoyang Zhao, Zhuangjie Fang, Liping Zhang, Qingbo Zhang, Changsheng Zhang, Yiguang Zhu   +7 more
openaire   +2 more sources

Asymmetric Synthesis of Druglike Six-Membered Spirooxindoles through an Amino Enyne Catalysis

, 2016
An effective reflexive-Michael (r-M) reaction has been disclosed to access drug-like six-membered spirooxindoles in good yields and excellent enantioselectivities by using an aminoenyne ...
R. Madhavachary (1944643), D. B. Ramachary (1909336), Chintalapudi Venkaiah (1909333)   +2 more
core   +1 more source