Results 61 to 70 of about 1,205 (207)

Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update

Beilstein Journal of Organic Chemistry, 2016
Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these
Bin Yu, Hui Xing, De-Quan Yu, Hong-Min Liu   +3 more
doaj   +1 more source

Catalytic Asymmetric Synthesis of gem‐Dicyano‐Spirocyclopropyl Oxindoles by N‐9‐Anth‐PyBidine‐Co(OAc)2: Advantage of Three‐Component Coupling Approach

ChemistryEurope, Volume 4, Issue 3, March 2026.
Chiral gem‐dicyano‐spirocyclopropyl oxindoles are obtained by a chiral N‐9‐Anth‐PyBidine‐Co(OAc)2‐catalyzed asymmetric Michael/alkylation reaction of 3‐chlorooxindoles with alkylidenemalononitriles. The three‐component coupling reaction of 3‐chlorooxindoles, aldehydes, and malononitrile shows the advantage of not requiring the preparation of ...
Takaaki Saito, Ren Miyasaka, Kazumasa Kon, Yuri Takagi, Takayoshi Arai   +4 more
wiley   +1 more source

Asymmetric Organocatalytic Cascade Synthesis of Tetrahydro­furanyl Spirooxindoles

, 2017
An enantio- and regioselective organocatalytic cascade starting from isatin has been disclosed to construct tetrahydrofuranyl spirooxindoles in high yields and stereoselectivities.
Ivar Järving, Dmitri Trubitsõn, Kadri Kriis, Sergei Žari, Tõnis Kanger, Sandra Kaabel, Tõnis Pehk, Marina Kudrjashova   +7 more
core   +1 more source

6′-Amino-5,7-dibromo-2-oxo-3′-(trifluoromethyl)-1′H-spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-5′-carbonitrile

Molbank, 2021
The multicomponent reactions are environmentally benign synthetic methods of building-up of complex molecules and several levels of structural diversity for diverse applications.
Yuliya E. Ryzhkova, Varvara M. Kalashnikova, Michail N. Elinson   +2 more
doaj   +1 more source

Next‐Generation Proteolysis‐Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs)‐mediated protein degradation has been recently developed as a game‐changing approach in oncology drug development. It represents a paradigm shift from traditional enzyme inhibition to selective protein degradation.
Mohamed S. Nafie, Mohamed K. Diab, Asmaa S. A. Yassen, Amany M. Elshamy, Mohamed R. El Tohamy, Haytham O. Tawfik, Sherif Ashraf Fahmy   +6 more
wiley   +1 more source

Stereoselective Synthesis of Five-Membered Spirooxindoles through Tomita Zipper Cyclization

, 2016
Functionalized five-membered spirooxindoles were furnished in good yields and excellent stereoselectivities by using an effective Tomita zipper cyclization (TZC) reaction through organophosphine ...
Patoju M. Krishna (1909330), D. B. Ramachary (1909336), Chintalapudi Venkaiah (1909333)   +2 more
core   +1 more source

Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization

Natural Products and Bioprospecting, 2017
A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products.
Ting Wu, Zhiqiang Pan, Chengfeng Xia
doaj   +1 more source

Chemo-selective Synthesis of [indoline-3,4'-isoxazolo[5,4-b]pyridine Fused spirooxindole Derivatives via Brønsted Acid Catalysed Three–Component Tandem Knoevenagel/Michael Addition Reaction

Results in Chemistry, 2020
With their exceptional three-dimensional structural topographies, spirooxindoles are known best for privileged chemotypes for diverse biological applications.
Dhruba Jyoti Boruah, Ram Awatar Maurya, Panneerselvam Yuvaraj   +2 more
doaj   +1 more source

Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

ChemistryEurope, Volume 3, Issue 5, September 18, 2025.
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés, Birane Diop, Xingyu Jiang, Jean Rodriguez, Muriel Amatore, Thierry Constantieux   +5 more
wiley   +1 more source

Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold

Frontiers in Plant Science, 2023
Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension.
Tuan-Anh M. Nguyen, Dagny Grzech, Khoa Chung, Zhicheng Xia, Trinh-Don Nguyen, Thu-Thuy T. Dang   +5 more
doaj   +1 more source