Results 41 to 50 of about 1,205 (207)

Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction

Molecules, 2019
Nucleobase-containing isoxazolidines spiro-bonded to an indane core have been synthesized in very good yields by regio- and diastereoselective 1,3-dipolar cycloaddition starting from indanyl nitrones and N-vinylnucleobases by using environmentally benign
Loredana Maiuolo, Vincenzo Algieri, Beatrice Russo, Matteo Antonio Tallarida, Monica Nardi, Maria Luisa Di Gioia, Zahra Merchant, Pedro Merino, Ignacio Delso, Antonio De Nino   +9 more
doaj   +1 more source

Aza-Diels-Alder reaction of both electron-deficient azoalkenes with electron-deficient 3-phencaylideneoxindoles and 3-aryliminooxindol-2-ones

Green Synthesis and Catalysis, 2021
An uncommon aza-Diels-Alder reaction of electron-deficient azoalkenes and electron-deficient 3-phenacylideneoxindoles was successfully developed for convenient construction of the heterocyclic spirooxindoles.
Wenjing Shi, Jing Sun, Chao-Guo Yan
doaj   +1 more source

Iodide/H2O2 Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles

Molecules, 2018
An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2′-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields.
Yu-Ting Gao, Xiao-Yang Jin, Qi Liu, An-Di Liu, Liang Cheng, Dong Wang, Li Liu   +6 more
doaj   +1 more source

Sonochemical multi-component synthesis of spirooxindoles

Ultrasonics Sonochemistry, 2011
New and efficient multi-component methods have been developed for the synthesis of spirooxindoles in the presence of a catalytic amount of p-TSA as an inexpensive and available catalyst in EtOH under ultrasound irradiation. The method is simple, starts from readily accessible commercial starting materials, and provides biologically interesting products
Minoo, Dabiri, Zeinab Noroozi, Tisseh, Mahboobeh, Bahramnejad, Ayoob, Bazgir   +3 more
openaire   +2 more sources

Primary-tertiary diamine-catalyzed Michael addition of ketones to isatylidenemalononitrile derivatives

Beilstein Journal of Organic Chemistry, 2014
Simple primary-tertiary diamines easily derived from natural primary amino acids were used to catalyze the Michael addition of ketones with isatylidenemalononitrile derivatives. Diamine 1a in combination with D-CSA as an additive provided Michael adducts
Akshay Kumar, Swapandeep Singh Chimni
doaj   +1 more source

The regioselective synthesis of spirooxindolo pyrrolidines and pyrrolizidines via three-component reactions of acrylamides and aroylacrylic acids with isatins and α-amino acids

Beilstein Journal of Organic Chemistry, 2014
The regioselective three-component condensation of azomethine ylides derived from isatins and α-amino acids with acrylamides or aroylacrylic acids as dipolarophiles has been realized through a one-pot 1,3-dipolar cycloaddition protocol.
Tatyana L. Pavlovskaya, Fedor G. Yaremenko, Victoria V. Lipson, Svetlana V. Shishkina, Oleg V. Shishkin, Vladimir I. Musatov, Alexander S. Karpenko   +6 more
doaj   +1 more source

Diastereoselective Formal 1,3-Dipolar Cycloaddition of Trifluoroethyl Amine-Derived Ketimines Enables the Desymmetrization of Cyclopentenediones

Molecules, 2023
In this research, a metal-free diastereoselective formal 1,3-dipolar cycloaddition of N-2,2,2-trifluoroethylisatin ketimines and cyclopentene-1,3-diones which can efficiently lead to the desymmetrization of cyclopentene-1,3-diones is developed.
Lin-Qiang Li, Jian-Qiang Zhao, Yan-Ping Zhang, Yong You, Zhen-Hua Wang, Zhen-Zhen Ge, Ming-Qiang Zhou, Wei-Cheng Yuan   +7 more
doaj   +1 more source

Catalytic Stereoselective Synthesis of Diverse Oxindoles and Spirooxindoles from Isatins

, 2016
A strategy for the efficient two-step synthesis of triazole derivatives of oxindoles and spirooxindoles is presented. Using a common set of N-propargylated isatins, a series of mechanistically distinct stereoselective reactions with different ...
Jacob P. MacDonald (2095471), Annaliese K. Franz (1289460), Joseph J. Badillo (2095468), Gary E. Arevalo (2095474), Abel Silva-García (2095465)   +4 more
core   +1 more source

Enantioselective synthesis of spirooxindoles [PDF]

, 2022
This diploma thesis is focused on the enantioselective synthesis of spiro[cyclopentane- oxindoles] from 3-alkylideneoxindoles and 1-bromo-3-nitropropane catalyzed by chiral bifunctional organocatalysts.
Vopálenská, Andrea
core  

Regioselective Synthesis of Spiro-Oxindoles via a Ruthenium-Catalyzed Metathesis Reaction

Chemistry Proceedings, 2023
Spiro-oxindoles are important heterocyclic motifs found in various alkaloids, many of which exhibit pharmacological properties. Due to the remarkable biological activity of spiro-oxindoles, significant effort has been made towards the synthesis of ...
Pradip Debnath
doaj   +1 more source