Results 31 to 40 of about 1,887 (208)
Electrochemical Enantioselective Oxidation of Indoles via Chiral Phosphoric Acid Catalysis in Cooperation with H<sub>3</sub>PO<sub>4</sub> in Aqueous Media. [PDF]
Angew Chem Int Ed EnglA binary organic–inorganic acid cooperative catalytic system has been developed to achieve highly enantioselective electrochemical oxidative rearrangement of indoles. The use of electricity as an oxidant in this case showed several advantages including environmental benignity and improved enantiocontrol.
Tan X, Zhou Z, Shao M, Sun J.
europepmc +2 more sources
Scientific Reports, 2021 The first diastereoselective synthesis of spirothiooxindoles is reported via the Michael reaction between thiooxindoles and dibenzalacetones. The reaction was conducted without any catalyst or additive under green conditions, i.e., ethanol as the solvent
Firouz Matloubi Moghaddam +2 more
doaj +1 more source
3′,4′-Dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones as potential anti-cancer agents: synthesis and preliminary screening [PDF]
Royal Society Open Science, 2020 Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of biological activities including anti-cancer activity, and are therefore recognized as two privileged scaffolds in drug discovery. In the present study, 24 3′,4′-dihydro-2′H-
Maloba M. M. Lobe, Simon M. N. Efange
doaj +1 more source
Pharmaceutics, 2023 In this work, we first improved the aqueous solubility of biologically active spiro[cyclopropane-1,3′-oxindoles] (SCOs) via their complexation with different β-cyclodextrins (β-CDs) and proposed a possible mechanism of the complex formation.
Anna A. Kravtsova +5 more
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Transition metal-catalyzed synthesis of spirooxindoles
RSC Advances, 2021 Spirooxindoles are used as anticancer-, antiviral-, antimicrobial agents etc. The use of transition metals as catalysts for the synthesis of spirooxindoles is advancing rapidly. Here, we focus on recent advances in transition metal-catalyzed synthesis of spirooxindoles.
P. V. Saranya +3 more
openaire +3 more sources
Molecules, 2022 The [3+2] cycloaddition (32CA) reaction of an azomethine ylide (AY) with an electrophilic ethylene linked to triazole and ferrocene units has been studied within the Molecular Electron Density Theory (MEDT) at the ωB97X-D/6-311G(d,p) level.
Luis R. Domingo +2 more
doaj +1 more source
Heliyon, 2020 A sequential multi-component reaction of the nitroketene dithioacetals, cysteamine hydrochloride, isatin and different CH-acids is described. This efficient method provides new functionalized thiazolo pyridine-fused spirooxindoles and thiazolo ...
Shima Nasri +3 more
doaj +1 more source
Molecules, 2023 In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine ...
Amani Toumi +11 more
doaj +1 more source
Synthesis and Diversification of Chiral Spirooxindoles via Organocatalytic Cascade Reactions
Chemistry Proceedings, 2023 The synthesis of chiral spirooxindoles through different amino catalytic activation modes is described herein. Several alkenylisatins were obtained from the Knoevenagel reaction of isatin and activated methylene derivatives containing electron ...
Jessica Navarro Vega +2 more
doaj +1 more source
Asymmetric Organocatalytic Synthesis of aza-Spirocyclic Compounds from Isothiocyanates and Isocyanides [PDF]
, 2021 The spirocyclic motif is present in natural products, chiral ligands, and compounds of pharmacological interest. Isothiocyanates as well as isocyanides bearing electron-withdrawing groups in the α-position can be deprotonated and react as formal dipoles ...
Blay Llinares, Gonzalo +4 more
core +1 more source