Results 31 to 40 of about 1,205 (207)

Synthesis, Characterization, and Cytotoxicity of New Spirooxindoles Engrafted Furan Structural Motif as a Potential Anticancer Agent

, 2022
A new series of spirooxindoles based on ethylene derivatives having furan aryl moiety are reported. The new hybrids were achieved via [3 + 2] cycloaddition reaction as an economic one-step efficient approach.
Saied M. Soliman, Nora Hamad Al-Shaalan, Altowyan, Mezna Saleh, Soliman, Saied M., Mezna Saleh Altowyan, Barakat, Assem, Alkharboush, Aminah A., Aminah A. Alkharboush, Haukka, Matti, Hamad Al-Shaalan, Nora, Al-Shaalan, Nora Hamad, Matti Haukka, Assem Barakat   +12 more
core   +3 more sources

The Synthesis of 3-Spirooxindole Derivatives. IV. The Conversion of 3-Spirooxindole to Indole Derivative.

Chemical and Pharmaceutical Bulletin, 1963
The conversion of 1-methylspiro (indoline-3, 1'-indolizine)-2-one to 12-methyl-1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a] quinolizine is described as a preliminary for the chemical correlation of N-methylrhynchophyllane with N-methyldihydrocorynantheane.
Oishi, Takeshi, Maeno, Shizuo, Ban, Yoshio   +2 more
openaire   +3 more sources

Diastereodivergent Desymmetric Annulation to Access Spirooxindoles: Chemical Probes for Mitosis

, 2023
Spirooxindoles have emerged as promising architectures for engineering biologically active compounds. The diastereodivergent construction of unique scaffolds of this type with full control of continuous chiral centers including an all-carbon quaternary ...
Shuai Li (65944), Yu-Hua Wen, Xuebiao Yao (9931), Shuai Li, Jin Song, Xuebiao Yao, Jin Song (276305), Yu-Hua Wen (2091697), Fengrui Yang (11187022), Liu-Zhu Gong (1499827), Fengrui Yang, Liu-Zhu Gong   +11 more
core   +1 more source

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited treatment options due to its heterogeneity and the lack of well-defined molecular targets.
Wagdy M. Eldehna, Dina H. EL-Naggar, Ahmed R. Hamed, Hany S. Ibrahim, Hazem A. Ghabbour, Hatem A. Abdel-Aziz   +5 more
doaj   +1 more source

Dipolarophile-Controlled Regioselective 1,3-Dipolar Cycloaddition: A Switchable Divergent Access to Functionalized N-Fused Pyrrolidinyl Spirooxindoles

, 2023
N-fused pyrrolidinyl spirooxindole belongs to a class of privileged heterocyclic scaffolds and is prevalent in natural alkaloids and synthetic pharmaceutical molecules.
Jianwei Dong, Sujin Li, Hongying Lu, Yongchao Wang, Lijun Yan, Jia Liu, Yuxin Yan   +6 more
core   +1 more source

An Efficient Synthesis of Oxygen-Bridged Spirooxindoles via Microwave-Promoted Multicomponent Reaction

Molecules, 2023
A microwave-promoted multicomponent reaction of isatins, α-amino acids and 1,4-dihydro-1,4-epoxynaphthalene is achieved under environmentally friendly conditions, delivering oxygen-bridged spirooxindoles within 15 min in good to excellent yields.
Yaojing Shi, Hua Zhao, Yufen Zhao
doaj   +1 more source

An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction

Molecules, 2015
A series of hitherto unreported anthracene-embedded dispirooxindoles has been synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of an azomethine ylide, generated in situ from the reaction of isatin and sarcosine to 10 ...
Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, J. Carlos Menéndez, Mujeeb A. Sultan, Usama Karama, Hazem A. Ghabbour, Hoong-Kun Fun   +7 more
doaj   +1 more source

Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation

Frontiers in Chemistry, 2021
The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis.
Yasmine M. Abdel Aziz, Gehad Lotfy, Mohamed M. Said, El Sayed H. El Ashry, El Sayed H. El Tamany, Saied M. Soliman, Marwa M. Abu-Serie, Mohamed Teleb, Sammer Yousuf, Alexander Dömling, Luis R. Domingo, Assem Barakat   +11 more
doaj   +1 more source

Catalytic Enantioselective Synthesis of Spirooxindoles by Oxidative Rearrangement of Indoles

, 2021
Oxidative rearrangement of indoles to access oxindoles has been used as a key step in complex molecule synthesis. We report a catalytic enantioselective variant of this transformation by chiral phosphoric acid catalysis, providing rapid access to a range
Qian, Chenxiao, Pengfei Li, Sun, Jianwei, Chenxiao Qian, Jianwei Sun, Li, Pengfei   +5 more
core   +1 more source

Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells

Scientific Reports, 2023
Recently, cancer research protocols have introduced clinical-stage spirooxindole-based MDM2 inhibitors. However, several studies reported tumor resistance to the treatment.
Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Essam Nageh Sholkamy, Assem Barakat, Maurizio Viale, Paola Menichini, Andrea Speciale, Fabrizio Loiacono, Mohammad Azam, Ved Prakash Verma, Sammer Yousuf, Mohamed Teleb   +11 more
doaj   +1 more source